Sleep disordered breathing and acute mountain sickness in workers rapidly transported to the South Pole (2835m)

Anderson, Paul J.; Wiste, Heather J.; Ostby, Stuart A.; Miller, Andrew D.; Ceridon, Maile L.; Johnson, Bruce D.

doi:10.1016/j.resp.2015.01.012

Cited by 10 publications

(6 citation statements)

References 12 publications

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“…This was confirmed by a study using PSQI and AIS which reports decreased subjective sleep quality at high altitude, especially reduced general sleep quality and prolonged sleep induction [22]. For workers rapidly transported from sea level to high altitude, there are no statistically significant differences in polysomnographic parameters between subjects with AMS and those without AMS [23]. For people with CMS stationed at Tibet, the proportion of poor sleepers (defined as PSQI > 5) with severe CMS was 12.54-fold higher than that of good sleepers.…”

Section: Sleep Quality and Severity Of Mountain Sicknessmentioning

confidence: 68%

Sleep Disorder at High Altitude

Kong¹

2021

Updates in Sleep Neurology and Obstructive Sleep Apnea

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In this chapter, we discuss the occurrence, mechanism, clinical manifestations, outcomes, and managements of a commonly encountered sleep disorder of someone traveling in high altitude for working and sightseeing. Humans ascending to altitudes above 2500 m usually suffer from substantial disturbances in sleep quality as difficulty in sleep onset, frequent awakenings, respiratory disturbance, and a feeling of drowsiness on the next day. Data obtained from polysomnographic studies demonstrated several variations of sleep architecture in those healthy subjects ascending to high altitude during sleep, including periodic breathing and decreased non-rapid eye movement deep sleep stage 3 and 4 (in new nomenclature N3), which were usually accompanied by and the lowered arterial O 2 and restricted ventilation. Hypoxia is most severe during sleep and in correspondence to periodic breathing and sleep disturbance at high altitude. Poor sleep quality impairs cognition and executive abilities at high altitude though it may largely be improved after full time of acclimatization. Evidence-based choices for clinicians to treat sleep disorder at high altitude are relatively scarce at present. Supplemental oxygen and dietary nitrate are effective in alleviating nocturnal hypoxia. There is strong evidence supporting the efficacy and safety of acetazolamide and nonbenzodiazepines in minimizing periodic breathing and improving sleep quality at high altitude.

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Section: Sleep Quality and Severity Of Mountain Sicknessmentioning

confidence: 68%

Sleep Disorder at High Altitude

Kong¹

2021

Updates in Sleep Neurology and Obstructive Sleep Apnea

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“…Instead, the observed barometric pressures during 2006 and 2007 of 512.7 ± 1.4 mmHg and 513 ± 4.6 mmHg, respectively, corresponded to equivalent altitudes of 3,197.4 ± 21.4 m (10,490 ft), and 3,183.7 ± 70.1 m (10,445 ft), and a partial pressure of inspired oxygen (PiO 2 ) of 97.6 ± 0.6 hmmHg, which is comparable to an altitude of 3,200 hm (10,500 ft). In fact, due to the unique characteristics of the Antarctic physical environment, the polar conditions may have magnified the risk of AMS when compared to incidence rates at similar altitudes [17,19,30]. Another reason for intensified AMS incidences may be related to false-positive results related to the confounding effects of "altitude-like symptoms" such as travel, change in routine, and anxiety [31].…”

Section: Discussionmentioning

confidence: 99%

“…Studies were performed over two summer expeditions to McMurdo Station (sea level) and Amundsen-Scott South Pole Station (high altitude) in 2006 and 2007, and were approved by the Institutional Review Board at the Mayo Clinic in Rochester, Minnesota and meet the ethical standards of this journal [15]. Parts of the data generated by the Antarctic Study of Altitude Physiology have been published elsewhere [16][17][18][19][20].…”

Section: Methodsmentioning

confidence: 99%

“…As a result, study participants were able to take acetazolamide at their discretion; however, the use of acetazolamide did not change AMS incidence in this study, and physical activity metrics were not different between acetazolamide users and non-users. Second, the original Lake Louise Questionnaire was utilized rather than updating our AMS scoring based on the most recent update, in order to stay consistent with past published data generated by the Antarctic Study of Altitude Physiology [16][17][18][19][20]. The most recent update to the Lake Louise Questionnaire eliminated disturbed sleep as a questionnaire item [44], in our review of AMS incidence the AMS incidence was 40 % (n = 19) using both the new or original Lake Louise Scoring Questionnaire.…”

Section: Limitationsmentioning

confidence: 99%

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Relationship of Activity Patterns to Acute Mountain Sickness in South Pole Workers

et al. 2019

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This study aimed to evaluate the influence of physical activity on incidence of acute mountain sickness (AMS) by continuous activity monitoring in a free-living sample of South Pole workers over the initial 72 h at altitude exposure of 2,840 m (9,318 ft). Body Media activity monitors were worn by 47 healthy participants. AMS was defined by the Lake Louise symptom questionnaire. Venous blood samples were taken at sea level and approximately 48 h after high altitude exposure. AMS incidence was 34% (n=16/47) over the first 48 h and 40% (n=19/47) over 72 h. On day 2 at high altitude, individuals with AMS demonstrated a significantly greater increase in the percent change in physical activity metrics from baseline: total energy expenditure 19±13 vs. 5±7%, total steps 65±51 vs. 10±18%, metabolic equivalent of tasks 21±13 vs. 7±13%, and time spent performing moderate to vigorous physical activity 114±79 vs. 26±27% for individuals with AMS vs. no AMS, respectively, p<0.05. In addition, erythropoietin and vascular endothelial growth factor were 1.69 and 1.75 times higher, respectively, in those with AMS. In conclusion, workers who engaged in increased physical activity and activity intensity during initial exposure to the South Pole were more susceptible to developing AMS.

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“…This study reports data on 38 healthy 25-37-year-old, not acclimatized, individuals after a 3-hour flight from sea level to a South Pole research station at an altitude of 2835 m (Anderson et al, 2015). Acute mountain sickness (AMS) was assessed over the first 3 days, defining AMS as a Lake Louise score > 2 with headache.…”

Section: Sleep-disordered Breathing In Healthy Individuals At Moderatmentioning

confidence: 99%

Sightings edited by Erik Swenson and Peter Bärtsch

2015

High Altitude Medicine & Biology

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Sleep disordered breathing and acute mountain sickness in workers rapidly transported to the South Pole (2835m)

Cited by 10 publications

References 12 publications

Sleep Disorder at High Altitude

Sleep Disorder at High Altitude

Relationship of Activity Patterns to Acute Mountain Sickness in South Pole Workers

Sightings edited by Erik Swenson and Peter Bärtsch

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