Sleep Difficulties in Infants at Risk for Developmental Delays: A Longitudinal Study

Scher, Anat; Tse, Lillian; Hayes, Virginia E.; Tardif, Megan

doi:10.1093/jpepsy/jsn013

Cited by 12 publications

(8 citation statements)

References 57 publications

(47 reference statements)

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“…Sleep problems are most likely related to behavioral factors (e.g., inability to self-calm, anxiety, and impaired communication) [13] and to circadian sleep-wake cycle abnormalities that are attributable to abnormally low levels of melatonin [14]. Sleep patterns differed and deviated in infants with NDDs compared to their unaffected counterparts, with developmental inconsistencies in sleep-wake state organization during the infancy period [15,16]; however, the association was not recognized by Scher et al [17]. Furthermore, sleep problems of children not only cause the mental and physical burdens for their caregivers and family members [18], but also influence their school attendance as part of communal living [19].…”

Section: Introductionmentioning

confidence: 99%

Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders

Yuge

Nagamitsu

Ishikawa³

et al. 2020

BMC Psychiatry

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Background Clinical evidence is required about the long-term efficacy and safety of melatonin treatment for sleep problems in children with neurodevelopmental disorders (NDDs) who underwent adequate sleep hygiene interventions. Methods We conducted a 26-week, multicenter, collaborative, uncontrolled, open-label, phase III clinical trial of melatonin granules in children 6 to 15 years of age who had NDDs and sleep problems. The study consisted of the 2-week screening phase, the 26-week medication phases I and II, and the 2-week follow-up phase. Children received 1, 2, or 4 mg melatonin granules orally in the medication phases. Variables of sleep status including sleep onset latency (SOL), aberrant behaviors listed on the Aberrant Behavior Check List-Japanese version (ABC-J), and safety were examined. The primary endpoint was SOL in the medication phase I. Results Between June 2016 and July 2018, 99 children (80 males and 19 females, 10.4 years in mean age) were enrolled at 17 medical institutions in Japan—74, 60, 22, 9, 6, and 1 of whom had autism spectrum disorder, attention-deficit/hyperactivity disorder, intellectual disabilities, motor disorders, specific learning disorder, and communication disorders, respectively, at baseline. Fifteen children received the maximal dose of 4 mg among the prespecified dose levels. SOL recorded with the electronic sleep diary shortened significantly (mean ± standard deviation [SD], − 36.7 ± 46.1 min; 95% confidence interval [CI], − 45.9 to − 27.5; P < 0.0001) in the medication phase I from baseline, and the SOL-shortening effect of melatonin persisted in the medication phase II and the follow-up phase. Temper upon wakening and sleepiness after awakening improved significantly (P < 0.0001 each) in the medication phase I from baseline and persisted in the follow-up phase. The following subscales of the ABC-J improved significantly: stereotypic behavior (P = 0.0322) in the medication phase I; and irritability, hyperactivity, and inappropriate speech (P < 0.0001) in the medication phase II. Treatment-emergent adverse events did not occur subsequent to week 16 after medication onset, and NDDs did not deteriorate in the follow-up phase. Conclusions Long-term melatonin treatment in combination with adequate sleep hygiene interventions may afford clinical benefits to children with NDDs and potentially elevates their well-being. Trial registration ClinicalTrils.gov, NCT02757066. Registered April 27, 2016.

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Section: Introductionmentioning

confidence: 99%

Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders

Yuge

Nagamitsu

Ishikawa³

et al. 2020

BMC Psychiatry

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“…Em estudo realizado com 142 crianças no Canadá, comparou-se a percepção dos pais em relação aos padrões e hábitos de sono de bebês utilizando um questionário adaptado, com base no Infant Sleep Questionnaire (ISQ), denominado Sleep-Q. Este questionário apresentava diferentes indicadores de risco de desenvolvimento obtidos através do Harris Infant Neuromotor Test (HINT), em períodos de 4-6 meses e 10-12 meses e evidenciou que as crianças com progresso nos marcos do desenvolvimento apresentaram maiores dificuldades de sono (11) . Assim, as crianças que apresentaram alto risco de atrasos e deficiências neuromotoras não obtiveram escores muito diferentes das com baixo risco.…”

Section: Resultsunclassified

A Influência Dos Distúrbios Do Sono No Desenvolvimento Infantil

Cardoso¹,

Lélis²,

Oliveira³

et al. 2014

Cogitare Enferm.

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Objetivou-se averiguar em publicações científicas a influência dos distúrbios do sono no desenvolvimento infantil. Revisão integrativa da literatura, realizada no mês de dezembro de 2012 e março de 2014 nas bases de dados: LILACS, Pubmed, CINAHL, Scopus e Cochrane, abrangendo o periodo de publicação de 2003 a março de 2014, com os descritores desenvolvimento infantil e distúrbios do sono. Como amostra da pesquisa, foram selecionados oito artigos constantes na base de dados SCOPUS e três na PubMed. Sendo dois desses artigos indexados repetidamente nas duas bases supracitadas. Dessa forma, resultou em uma amostra final de nove artigos publicados entre 2007 e 2013; três são do tipo longitudinal e seis são revisões de literatura. A síntese dos resultados aponta evidências do distúrbio de sono como possível influenciador em alterações no desenvolvimento, principalmente, no aspecto cognitivo e comportamental.

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“…Changes occur in infant sleep patterns at 4-6 months and at 10-12 months and with the occurrence of circadian rhythm at around 4 months, children begin to have a sound sleep of 7 hours. 9,17,18 Night waking frequency was reported in the United States as 35%, in Switzerland as 30.8%, and in Australia as 17.8%. [19][20][21] In our study, night waking was more common than reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…7 Studies from different countries and different age groups reported the night-time sleep duration as 7.7±1.3 to 11.7±1.0 hours. 9,11,13,14,33 Behaviours such as breastfeeding, sleeping in the same room and the same bed with parents or siblings, bottle-feeding when the child wakes up at night, and bringing the child to the parents' bed reduce sleep duration. 14,30 An interesting finding of our study is the longer mean night sleep duration among children whose parents did preparations before sleeping.…”

Section: Discussionmentioning

confidence: 99%

“…1,6,7 The most common way of obtaining information about the sleep habits of children is through observation of the families. [8][9][10] Identifying sleep characteristics such as the duration of sleep and bedtime/daytime sleep habits is very important in understanding sleep-related problems. 11 However, sleep problems in childhood may remain undetected during routine visits and little is known about how parents describe/report sleep problems in their children.…”

mentioning

confidence: 99%

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Sleep Habits and Factors Associated with Sleep Problems Among Children in Southeastern Turkey

Araz¹,

Yılmaz²,

Gökçay³

2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Sleep has an important role in child development and is necessary for supporting optimal health for lifetime. This study examined the sleep habits of children in southeastern Turkey and certain risk factors that contribute to sleep problems. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The study included 300 parents who visited the paediatric outpatient department of Gaziantep University Hospital and agreed to complete the questionnaire. The questionnaire was based on the significant variables found in a review of the previous literature on childhood sleep, and was examined tested in a pilot study. Statistical significance was determined as p<0.05. R Re es su ul lt ts s: : The ages of the children (171 males, 129 females) included in the study ranged from 1 month to 12 years (median age 2.0 years). Fifty-three percent (128) of the children experienced night waking, 38.0% (114) had difficulty falling asleep and 39.3% (118) demonstrated bedtime resistance. Difficulty in falling asleep and bedtime resistance were more common among children whose parents did something to soothe them when they woke up crying, and whose bedtime varied each night (p<0.05). Night waking was affected by factors such as soothing the child when waking up crying, irregular bedtime and sleeping during the daytime (p<0.05). Parents were more likely to soothe the children who slept in the same room (p<0.001). The mean night sleep duration was longer among children whose parents did preparations before sleeping (p=0.010). C Co on nc cl lu us si io on n: : Sleep problems are very common in childhood. Certain factors such as irregular bedtime routines, varying bedtimes, and soothing activities are important factors in the development of sleep problems. Therefore, sleep problems and sleep quality should be assessed in routine visits to the paediatrician. K Ke ey y W Wo or rd ds s: : Sleep; child; Turkey; parasomnias Ö ÖZ ZE ET T A Am ma aç ç: : Çocuk gelişiminde önemli bir role sahip olan uyku, yaşam boyunca sağlıklı olmak açısın-dan gereklidir. Bu çalışmada, Güneydoğu Anadolu bölgesindeki çocukların uyku alışkanlıkları ve uyku problemlerinin gelişimine katkıda bulunan bazı risk faktörlerinin belirlenmesi amaçlandı. G Ge er re eç ç v ve e Y Yö ön n--t te em ml le er r: : Çalışmaya Gaziantep Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı polikliniklerine başvuran ve anket formunu doldurmayı kabul eden 300 aile dâhil edildi. Anket formu, çocukluk çağı uykusu hakkında daha önce yayımlanan literatürlerdeki önemli değişkenler incelenerek hazırlandı ve bir pilot çalışma ile soruların anlaşılabilirliği incelendi. Çalışmada p<0.05 değeri istatistiksel olarak anlamlı kabul edildi. B Bu ul lg gu ul la ar r: : Çalışmaya alınan çocukların (171 erkek, 129 kız) yaşları 1 ay-12 yaş arasında değişmekteydi (ortanca yaş 2,0 yıl). Çocukların %53'ünde (128) gece uyanmaları, %38'inde (114) uykuya dalma zorluğu ve %39,3'ünde (118) yatağa gitmeye direnme söz konusuydu. Uykuya ...

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Sleep Difficulties in Infants at Risk for Developmental Delays: A Longitudinal Study

Abstract: In a diverse sample of infants, with and without risks for developmental delays, overall, sleep patterns were similar. It appears that the neuromotor achievements are not associated with sleep-wake regulation, as measured by caregivers' report.

Cited by 12 publications

References 57 publications

Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders

Long-term melatonin treatment for the sleep problems and aberrant behaviors of children with neurodevelopmental disorders

A Influência Dos Distúrbios Do Sono No Desenvolvimento Infantil

Sleep Habits and Factors Associated with Sleep Problems Among Children in Southeastern Turkey

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