Sleep deprivation and Pavlovian fear conditioning

Cai, Denise J.; Shuman, Tristan; Harrison, E.; Sage, Jennifer R; Anagnostaras, Stephan

doi:10.1101/lm.1515609

Cited by 18 publications

(17 citation statements)

References 36 publications

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“…In rats, gentle handling 12 h posttraining interfered with contextual fear memory when rats were handled during either wake or sleep phases. 42 Although handling immediately …”

Section: Sleep Deprivation Does Not Affect Memory Recallmentioning

confidence: 99%

“…42 Handling can also produce unwanted side effects, including increased levels of glucocorticoids or changes in neurotransmitter receptors, that could conceivably mask the expression of memory. 43,44 To rule out potential stress-induced memory deficits caused by the physical handling of the animals during the sleep deprivation procedure, animals were handled with context changes for 9 h during the day similar to the degree of handling in corresponding sleep deprivation experiments, received LFI training at the end of the day at ZT 11 and then tested for LTM 24 h later.…”

Section: Sleep Deprivation Blocks the Induction Of Ltmmentioning

confidence: 99%

“…Similar to the protocol design used by Cai and colleagues to independently assess the effects of handling on associative memory, 42 animals were trained at ZT 11 and then remained undisturbed throughout the sleep phase. Animals were then …”

Section: Ltm) (A)mentioning

confidence: 99%

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Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory inAplysia

Krishnan

Gandour

Ramos

et al. 2016

Sleep

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Study Objectives: Insufficient sleep in individuals appears increasingly common due to the demands of modern work schedules and technology use. Consequently, there is a growing need to understand the interactions between sleep deprivation and memory. The current study determined the effects of acute sleep deprivation on short and long-term associative memory using the marine mollusk Aplysia californica, a relatively simple model system well known for studies of learning and memory. Methods: Aplysia were sleep deprived for 9 hours using context changes and tactile stimulation either prior to or after training for the operant learning paradigm, learning that food is inedible (LFI). The effects of sleep deprivation on short-term (STM) and long-term memory (LTM) were assessed. Results: Acute sleep deprivation prior to LFI training impaired the induction of STM and LTM with persistent effects lasting at least 24 h. Sleep deprivation immediately after training blocked the consolidation of LTM. However, sleep deprivation following the period of molecular consolidation did not affect memory recall. Memory impairments were independent of handling-induced stress, as daytime handled control animals demonstrated no memory deficits. Additional training immediately after sleep deprivation failed to rescue the induction of memory, but additional training alleviated the persistent impairment in memory induction when training occurred 24 h following sleep deprivation. Conclusions: Acute sleep deprivation inhibited the induction and consolidation, but not the recall of memory. These behavioral studies establish Aplysia as an effective model system for studying the interactions between sleep and memory formation.

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“…In rats, gentle handling 12 h posttraining interfered with contextual fear memory when rats were handled during either wake or sleep phases. 42 Although handling immediately …”

Section: Sleep Deprivation Does Not Affect Memory Recallmentioning

confidence: 99%

Section: Sleep Deprivation Blocks the Induction Of Ltmmentioning

confidence: 99%

See 1 more Smart Citation

Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory inAplysia

Krishnan

Gandour

Ramos

et al. 2016

Sleep

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“…This, however, is sheer speculation, and the cognitive significance of sleep is hard to assess, although sleep-deprived animals suffer impairments in learning (e.g. Graves et al 2003; but see Cai et al 2009 for dissent),…”

mentioning

confidence: 99%

Fish Cognition and Consciousness

Allen

2011

J Agric Environ Ethics

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“…It is unknown to what extent several aspects of circadian disruption contribute to specific learning deficits -e.g., exposure to light during subjective night; reduction in rhythm amplitude or synchrony; repeated phase-shifting, etc. Besides direct clock effects, various downstream physiological processes that are typically under circadian control such as sleep and activity may also contribute to learning and memory deficits [16,[29][30][31][32]. Thus, we may expect changes in learning and memory under bifurcated conditions.…”

Section: Introductionmentioning

confidence: 99%

Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact

Harrison

Carmack

Block

et al. 2017

Physiology & Behavior

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• The circadian system was experimentally bifurcated into two days and nights per 24 h.• Pavlovian fear conditioning was used to quantify acquisition and retrieval of memory.• Retrieval of cued fear remained intact in bifurcated, but not phase-shifted, mice. a b s t r a c t a r t i c l e i n f o In mammals, memory acquisition and retrieval can be affected by time of day, as well as by manipulations of the light/dark cycle. Under bifurcation, a manipulation of circadian waveform, two subjective days and nights are experimentally induced in rodents. We examined the effect of bifurcation on Pavlovian fear conditioning, a prominent model of learning and memory. Here we demonstrate that bifurcation of the circadian waveform produces a small deficit in acquisition, but not on retrieval of fear memory. In contrast, repeated phase-shifting in a simulated jet-lag protocol impairs retrieval of memory for cued fear. The results have implications for those attempting to adjust to shift-work or other challenging schedules.

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Sleep deprivation and Pavlovian fear conditioning

Cited by 18 publications

References 36 publications

Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory inAplysia

Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory inAplysia

Fish Cognition and Consciousness

Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact

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