Sleep deprivation and a non–24‐h working schedule lead to extensive alterations in physiology and behavior

Ma, Hongwei; Li, Yunzhen; Liang, Hongying; Chen, Shijunyin; Pan, Siyu; Chang, Lulin; Li, Silin; Zhang, Ying; Li, Xinyan; Xu, Yanwen; Shao, Yuanyuan; Yang, Yebing; Guo, Jinhu

doi:10.1096/fj.201802727r

Cited by 21 publications

(21 citation statements)

References 39 publications

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“…A survey of 122 submarine crew members indicated that over 77% of them had medical complaints, and most complaints were about sleeping difficulty [ 68 ]. However, prevalent studies have demonstrated that under non-24-h conditions, both the quantity and quality of sleep are altered [ 67 , 69 , 70 ]. In real missions, the sleep time of the submarine crew varies in a wide range, extending from 5.75 h to 9 h, which may be influenced by many environmental factors [ 60 ].…”

Section: Effects Of Non-24-h Conditions On Human Health and Performanmentioning

confidence: 99%

“…The level of insulin is under the control of the circadian clock, which peaks at night in humans [ 78 ]. Ma et al [ 70 ] found that saliva insulin dramatically increased late at night and early in the morning in subjects under a schedule of 8 h for work and rest and 4 h for sleep. Consistently, the insulin levels and insulin: glucose ratios were increased in mice under LD 10 conditions [ 81 ].…”

Section: Effects Of Non-24-h Conditions On Human Health and Performanmentioning

confidence: 99%

“…Environmental changes might convert them to be pathogenic and trigger intestinal diseases or other inflammatory diseases [ 87 ]. Recently, Ma et al [ 70 ] found that disruption of the composition of the oral microbiome occurred in subjects living under a non-24-h schedule. Some bacterial species showed specific change patterns, e.g., Tenericutes and SR1, corresponding to sleep deprivation and circadian desynchronization, respectively.…”

Section: Effects Of Non-24-h Conditions On Human Health and Performanmentioning

confidence: 99%

“…During 2007, the effects of the existing watch schedules used in Canadian Forces were evaluated, revealing that the cognitive efficacy in the submarine crew dramatically decreased to a dangerously low level [ 93 ]. Ma et al [ 70 ] showed that under a 4-h on/8-h off routine, the alertness of the subjects decreased dramatically in the morning. As chronic sleep deprivation may occur during non-24-h cycles, it is unclear whether misaligned circadian rhythms or sleep loss contributed more to the decreased alertness.…”

Section: Effects Of Non-24-h Conditions On Human Health and Performanmentioning

confidence: 99%

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Circadian misalignment on submarines and other non-24-h environments – from research to application

Guo

et al. 2020

Military Med Res

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Circadian clocks have important physiological and behavioral functions in humans and other organisms, which enable organisms to anticipate and respond to periodic environmental changes. Disturbances in circadian rhythms impair sleep, metabolism, and behavior. People with jet lag, night workers and shift workers are vulnerable to circadian misalignment. In addition, non-24-h cycles influence circadian rhythms and cause misalignment and disorders in different species, since these periods are beyond the entrainment ranges. In certain special conditions, e.g., on submarines and commercial ships, non-24-h watch schedules are often employed, which have also been demonstrated to be deleterious to circadian rhythms. Personnel working under such conditions suffer from circadian misalignment with their on-watch hours, leading to increased health risks and decreased cognitive performance. In this review, we summarize the research progress and knowledge concerning circadian rhythms on submarines and other environments in which non-24-h watch schedules are employed.

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Section: Effects Of Non-24-h Conditions On Human Health and Performanmentioning

confidence: 99%

Section: Effects Of Non-24-h Conditions On Human Health and Performanmentioning

confidence: 99%

Section: Effects Of Non-24-h Conditions On Human Health and Performanmentioning

confidence: 99%

Section: Effects Of Non-24-h Conditions On Human Health and Performanmentioning

confidence: 99%

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Circadian misalignment on submarines and other non-24-h environments – from research to application

Guo

et al. 2020

Military Med Res

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“…Although numerous medical and ergonomical problems have been reported, rotating shift work schedules are still commonly employed in industrial society including maritime tasks and the detrimental effects have not been su ciently concerned. For instance, non-24 h and frequently rotating schedules are commonly used in maritime missions [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Circadian Misalignment Leads to Changes in Cortisol Rhythms, Blood Biochemical Variables and Serum miRNA Profiles

Huang¹,

Ma²,

Gan³

et al. 2021

Preprint

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Background: Circadian clock plays a critical role in synchronizing the inner molecular, metabolic and physiological processes to the environmental cues which cycle with a period of 24 h. Misalignment in the circadian rhythms leads to decrease in adaptation, performance and increased risk of associated disorders. The non-24-h schedules and shift schedules are commonly used in maritime operations, both of which could result in disturbance in circadian rhythms. The comprehensive effects of these schedules remain to be further elucidated.Methods: In this study, we firstly conducted an experiment in which the volunteers followed a 3-d rotary schedule with consecutive shift in sleep time (rotatory schedule), and analyzed the changes in salivary cortisol rhythms and blood variables. Next we conducted another experiment in which the volunteers followed an 8 h on and 4 h off schedule (non-24-h schedule) to compare the changes in blood/serum variables. Furthermore, the plasma miRNAs from the volunteers following the rotatory schedule were subject for miRNA sequencing. Results: The rotatory schedule led to elevated levels of serum cortisol during the early stage, and the phase became delayed during the early and stages. The results show both of the schedules caused comprehensive changes in blood/serum biochemical variable, and consistently, the increase in phosphate levels. In addition, a subset of serum miRNAs targeting genes involved in circadian rhythms, sleep homeostasis and multiple important physiological processes or pathways were identified in the experiment with rotatory schedule.Conclusions: This study revealed an increased stress during the rotatory schedule. Circadian misalignment caused by either non-24-h or rotatory schedule lead to extensive changes in blood/serum variables. As to the rotatory schedule, altered expression of serum miRNAs may account for the consequences of circadian misalignment. These findings would help understand the deleterious effects of shift schedules and optimize to enhance performance and welfare of the personnel working with similar schedules.

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Sleep and Circadian Clock: Novel Players in Health Impacts and Aging

Jagota

2023

Healthy Ageing and Longevity

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Sleep deprivation and a non–24‐h working schedule lead to extensive alterations in physiology and behavior

Cited by 21 publications

References 39 publications

Circadian misalignment on submarines and other non-24-h environments – from research to application

Circadian misalignment on submarines and other non-24-h environments – from research to application

Circadian Misalignment Leads to Changes in Cortisol Rhythms, Blood Biochemical Variables and Serum miRNA Profiles

Sleep and Circadian Clock: Novel Players in Health Impacts and Aging

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