Sleep Deprivation Amplifies Reactivity of Brain Reward Networks, Biasing the Appraisal of Positive Emotional Experiences

Gujar, Ninad; Yoo, Seung‐Schik; Hu, Peter; Walker, Matthew P.

doi:10.1523/jneurosci.3220-10.2011

Cited by 388 publications

(314 citation statements)

References 71 publications

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“…What may be the neurophysiological mechanisms underlying these adverse effects of sleep disturbance? In the light of recent findings on the consequences of total SD and REM SD on decision making and reward function (Gujar et al 2011;Hanlon et al 2010;Venkatraman et al 2007;Yoo et al 2007), we suggest that sleep contributes to maintaining the integrity of emotional and reward brain networks (Sects. 2.1 and 2.2).…”

Section: Sleep Disturbance Causes Waking Emotional Dysfunctionsmentioning

confidence: 65%

“…These results suggest that SD causes a reduction of prefrontal control over the limbic system, resulting in an accentuation of emotional responses to negative stimuli. SD may also lead to an amplified reactivity of reward networks in response to positive emotional stimuli (Gujar et al 2011). More specifically, compared to a non sleep-deprived control group, sleep-deprived participants judged pleasure-evoking stimuli as more pleasant, and showed increased activation in the VTA, left putamen, amygdala and left insula.…”

Section: Sleep Disturbance Causes Waking Emotional Dysfunctionsmentioning

confidence: 99%

See 1 more Smart Citation

Sleep and Emotional Functions

Perogamvros

Schwartz

2013

Sleep, Neuronal Plasticity and Brain Function

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In this chapter, we review studies investigating the role of sleep in emotional functions. In particular, evidence has recently accumulated to show that brain regions involved in the processing of emotional and reward-related information are activated during sleep. We suggest that such activation of emotional and reward systems during sleep underlies the reprocessing and consolidation of memories with a high affective and motivational relevance for the organism. We also propose that these mechanisms occurring during sleep promote adapted cognitive and emotional responses in the waking state, including overnight performance improvement, creativity, and sexual functions. Activation across emotional-limbic circuits during sleep also appears to promote emotional maturation and the emergence of consciousness in the developing brain.

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Section: Sleep Disturbance Causes Waking Emotional Dysfunctionsmentioning

confidence: 65%

Section: Sleep Disturbance Causes Waking Emotional Dysfunctionsmentioning

confidence: 99%

Sleep and Emotional Functions

Perogamvros

Schwartz

2013

Sleep, Neuronal Plasticity and Brain Function

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show abstract

“…For example, REM sleep deprivation is used as a treatment in some andrological post-surgeries to avoid REM-related erections, and several works have also shown the usefulness of REM sleep restriction in the treatment of depression [4,5].…”

Section: Introductionmentioning

confidence: 99%

Monitoring sleep depth: analysis of bispectral index (BIS) based on polysomnographic recordings and sleep deprivation

Giménez

Romero

Alonso

et al. 2015

J Clin Monit Comput

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The assessment and management of sleep are increasingly recommended in the clinical practice. Polysomnography (PSG) is considered the gold standard test to monitor sleep objectively, but some practical and technical constraints exist due to environmental and patient considerations. Bispectral index (BIS) monitoring is commonly used in clinical practice for guiding anesthetic administration and provides an index based on relationships between EEG components. Due to similarities in EEG synchronization between anesthesia and sleep, several studies have assessed BIS as a sleep monitor with contradictory results. The aim of this study was to evaluate objectively both the feasibility and reliability of BIS for sleep monitoring through a robust methodology, which included full PSG recordings at a baseline situation and after 40h of sleep deprivation. Results confirmed that the BIS index was highly correlated with the hypnogram (0.89±0.02), showing a progressive decrease as sleep deepened, and an increase during REM sleep (awake: 91.77±8.42; stage N1: 83.95±11.05; stage N2: 71.71±11.99; stage N3: 42.41±9.14; REM: 80.11±8.73). Mean and median BIS values were lower in the postdeprivation night than in the baseline night, showing statistical differences for the slow wave sleep (baseline: 42.41±9.14 vs post-deprivation: 39.49±10.27; p=0.02). BIS scores were able to discriminate properly between deep (N3) and light (N1, N2) sleep. BIS values during REM overlapped those of other sleep stages, although EMG activity provided by the BIS monitor could help to identify REM sleep if needed. In conclusion, BIS monitors could provide a useful measure of sleep depth in especially particular situations such as intensive care units, and they could be used as an alternative for sleep monitoring in order to reduce PSG-derived costs and to increase capacity in ambulatory care.

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“…In addition, this amplified reactivity was associated with enhanced connectivity in the early primary visual processing pathways and extended limbic regions, yet with a reduction in coupling with medial frontal and orbitofrontal regions. These neural changes were accompanied by a biased increase in the number of emotional stimuli judged as pleasant in the sleep-deprived group, the extent of which exclusively correlated with activity in mesolimbic regions (Gujar et al, 2011b). These results may offer a neural foundation on which to consider interactions between sleep loss and emotional reactivity in a variety of mood disorders (Gujar et al, 2011b).…”

Section: Overview Of Human Neuroimaging Datamentioning

confidence: 86%

“…Accordingly, an extensive body of research has revealed a cruicial role for sleep in human cognitive abilities (Mander et al, 2008;Schabus et al, 2006;2008;Yoo et al, 2007b), heuristic creativity and insightfulness (Cai et al, 2009;Stickgold et al, 1999;2001;Wagner et al, 2004;Yordanova et al, 2008;, constructive thinking and decision making (Durrant et al, 2011;Venkatraman et al, 2011), and emotional regulation (Walker, 2009;Walker & van der Helm, 2009). The latter engages consolidation of emotional memory (Nishida et al, 2009;Wagner et al, 2001;2006;Walker, 2009) and emotional processing (Gujar et al, 2011a;2011b;Yoo et al, 2007a). Collectively, these various associations suggest that sleep provides unique conditions for off-line memory consolidation, reconsolidation and information reprocessing to take place.…”

Section: Introductionmentioning

confidence: 99%