Sleep deprivation alters neutrophil functions and levels of Th1-related chemokines and CD4+ T cells in the blood

Said, Elias A.; Abri, Mohammed Al; Al-Saidi, Iman; Al-Balushi, Mohammed S.; Al-Busaidi, Jumaa Z.; Al-Reesi, Iman; Koh, Crystal Y.; Idris, Mohamed A.; Al-Jabri, Ali A.; Habbal, Omar

doi:10.1007/s11325-019-01851-1

Cited by 30 publications

(24 citation statements)

References 30 publications

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“…Healthy volunteers sleeping less than 6 hours for a week had reduced levels of neutrophil phagocytosis, lower levels of NADPH oxidase, and fewer CD4þ T cells, which are necessary for anti-infective defense and proper vaccination response. The level of NADPH oxidase remained reduced even after a week of the restored amount of sleep, which indicated long-lasting effects of sleep deprivation [60]. Moreover, sleep deprived people immunized against the influenza A virus revealed a much lower level of antibodies than those immunized without sleep deprivation [61].…”

Section: Melatonin Can Reduce Immunosuppression Induced By Chronic Stmentioning

confidence: 96%

Can melatonin reduce the severity of COVID-19 pandemic?

Shneider

Kudriavtsev

Vakhrusheva

2020

International Reviews of Immunology

141

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The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly and people with diseases of chronic inflammation. Therefore, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks. Children don't suffer from COVID-19 as much as their grandparents and have a much higher melatonin level. Bats are nocturnal animals possessing high levels of melatonin, which may contribute to their high anti-viral resistance. Viruses induce an explosion of inflammatory cytokines and reactive oxygen species, and melatonin is the best natural antioxidant that is lost with age. The programmed cell death coronaviruses cause, which can result in significant lung damage, is also inhibited by melatonin. Coronavirus causes inflammation in the lungs which requires inflammasome activity. Melatonin blocks these inflammasomes. General immunity is impaired by anxiety and sleep deprivation. Melatonin improves sleep habits, reduces anxiety and stimulates immunity. Fibrosis may be the most dangerous complication after COVID-19. Melatonin is known to prevent fibrosis. Mechanical ventilation may be necessary but yet imposes risks due to oxidative stress, which can be reduced by melatonin. Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the immuno-pathology of coronavirus infection on patients' health after the active phase of the infection is over. ARTICLE HISTORY

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Section: Melatonin Can Reduce Immunosuppression Induced By Chronic Stmentioning

confidence: 96%

Can melatonin reduce the severity of COVID-19 pandemic?

Shneider

Kudriavtsev

Vakhrusheva

2020

International Reviews of Immunology

141

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“…For example, total sleep deprivation for 40 h in 19 healthy men and women was associated with increases in adhesion markers and pro-inflammatory serum cytokines ( 4 ). Additionally, restricting sleep to <6 h per night for a week in eight healthy volunteers (50% female) has been reported to decrease neutrophil phagocytic activity and alter the ratio of the interferon(IFN)-γ induced T-cell and NK-cell attractant chemokines CXCL9/CXCL10 and CCL5/CCL9 and decrease the frequency of circulating CD4 + T-cells ( 5 ). Lastly, a 4-day simulated night shift protocol in which blood samples were collected over two 24-h periods from eight healthy individuals reported a significant reduction in diurnal transcripts related to NK cell responses and the Jun/AP1 and STAT pathways ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Probiotics, Anticipation Stress, and the Acute Immune Response to Night Shift

et al. 2021

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IntroductionSleep disturbance and sleep disruption are associated with chronic, low grade inflammation and may underpin a range of chronic diseases in night shift workers. Through modulation of the intestinal microbiota, probiotic supplements may moderate the effects of sleep disruption on the immune system. The aim of this study was to examine 14 days of daily probiotic supplementation on the acute response of acute phase proteins and immune markers to sleep disruption associated with night shift work (Australia and New Zealand Clinical Trials Registry: 12617001552370).MethodsIndividuals (mean age 41 ± 11 yrs; 74% female) performing routine night shift were randomly assigned to a probiotic group (1 × 1010 colony forming units (CFU) Lactobacillus acidophilus DDS-1 or 1 × 1010 CFU Bifidobacterium animalis subsp. lactis UABla-12) or placebo (n= 29 per group). Participants undertook a 14-day supplementation period that coincided with a period of no night shifts followed by two consecutive night shifts. Blood samples were collected prior to the start of supplementation (V1), prior to commencing the first night shift (V2), after the first night shift (V3) and after the second night shift (V4). Serum was assessed for markers of stress (cortisol), acute phase response (C reactive protein (CRP), erythrocyte sedimentation rate, pentraxin), adhesion markers (serum E-selectin, mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1), and serum cytokines (interleukin (IL)-1ra, IL-1β, IL-6, tumor necrosis factor (TNF)-α, IL-10). Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and a Fitbit activity tracker.ResultsThe groups were well balanced on key markers and the probiotic strains were well tolerated. The 14-day supplementation period that coincided with typical night-day sleep-wake cycles leading up to night shift (V1 to V2) was associated with significant changes in the placebo group in the concentration of serum cortisol (p = 0.01), pentraxin (p = 0.001), MAdCAM-1 (p = 0.001), and IL-1ra (p=0.03). In contrast, probiotic supplementation moderated changes in these serum markers from V1 to V2. No significant interaction effects (time by group) were observed for the serum markers prior to and after night shift work following probiotic supplementation due to the substantial changes in the serum markers that occurred during the normal sleep period from V1 to V2.ConclusionsProbiotics may moderate the effects of anticipatory stress on the immune system in the lead up to night shift.

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“…Healthy volunteers sleeping less than 6 hours for a week had reduced levels of neutrophil phagocytosis, lower levels of NADPH oxidase, and fewer CD4+ T cells, which are necessary for anti-infective defense and proper vaccination response. The level of NADPH oxidase remained reduced even after a week of the restored amount of sleep, which indicated long-lasting effects of sleep deprivation [53]. Moreover, sleep deprived people immunized against the influenza A virus revealed a much lower level of antibodies than those immunized without sleep deprivation [54].…”

Section: Melatonin Can Reduce Immunosuppression Induced By Chronic Stmentioning

confidence: 96%

Can Melatonin Reduce the Severity of COVID-19 Pandemic?

Shneider¹,

Kudriavtsev²,

Vakhrusheva³

2020

Preprint

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The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing lifethreatening danger to the elderly and people with diseases of chronic inflammation. So, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks. Children do not suffer from COVID-19 as much as their grandparents and have a much higher melatonin level. Bats also do not suffer from the virus they transmit, and bats too have a much higher level of melatonin. Viruses generate an explosion of reactive oxygen species, and melatonin is the best natural antioxidant that is lost with age. Melatonin inhibits the programmed cell death which coronaviruses induce, causing significant lung damage. Coronavirus causes inflammation in the lungs which requires inflammasome activity. Melatonin blocks the inflammasome. The immune response is impaired by anxiety and sleep deprivation. Melatonin improves sleep habits, reduces anxiety and stimulates immunity. Fibrosis may be the most dangerous complication after COVID-19. Melatonin is known to prevent fibrosis. Mechanical ventilation may be necessary but yet imposes risks due to oxidative stress, which can be reduced by melatonin. Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the negative effects of coronavirus infection on patients' health after the active phase of the infection is over.

show abstract

Sleep deprivation alters neutrophil functions and levels of Th1-related chemokines and CD4+ T cells in the blood

Cited by 30 publications

References 30 publications

Can melatonin reduce the severity of COVID-19 pandemic?

Can melatonin reduce the severity of COVID-19 pandemic?

Probiotics, Anticipation Stress, and the Acute Immune Response to Night Shift

Can Melatonin Reduce the Severity of COVID-19 Pandemic?

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