Sleep Deprivation Affects Thermal Pain Thresholds but Not Somatosensory Thresholds in Healthy Volunteers

Kundermann, Bernd; Spernal, Julia; Huber, Martin; Krieg, Jürgen-Christian; Lautenbacher, Stefan

doi:10.1097/01.psy.0000145912.24553.c0

Cited by 183 publications

(152 citation statements)

References 25 publications

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“…Prospective studies indicate that sleep problems are associated with an increased risk for longlasting musculoskeletal pain (9)(10)(11)(12)(13)(14)(15) and experimental studies suggest that even a relatively modest restriction or disturbance of sleep increases pain sensitivity. This is manifested as larger responses to experimentally induced pain (16)(17)(18)(19)(20)(21), as increased spontaneous pain (22)(23)(24), or as altered pain modulation (23,(25)(26)(27)(28)(29). A recent meta-analysis confirm that sleep restriction increases sensitivity for several types of pain (30).…”

mentioning

confidence: 74%

Night-shift work is associated with increased pain perception

Matre

Knardahl²,

Nilsen³

2017

Scand J Work Environ Health

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Night-shift work is associated with increased pain perception by Matre D, Knardahl S, Nilsen KB To the authors' knowledge, pain sensitivity after night shifts has never been investigated. The present findings indicate that pain sensitivity does increase for some types of pain stimuli. Furthermore, the results indicate that experimental sleep restriction studies are relevant in assessments of health complaints among shift workers. Original article Scand J Work Environ Health. 2017;43(3):260-268. doi:10.5271/sjweh.3627 Night-shift work is associated with increased pain perception Objectives The aim of the present study was to determine whether shift workers exhibit increased perception of experimentally induced pain after working night shifts. Affiliation MethodsThe study was a paired cross-over design with two sleep conditions, after at least two nights of habitual sleep and after two consecutive night shifts at work. Fifty-three nurses in rotating shift work participated. The sensitivity to electrically induced pain, heat pain, cold pain, pressure pain and pain inhibition was determined experimentally in each sleep condition. Sleepiness and vigilance were also assessed.Results Night-shift work (NSW) increased the sensitivity to electrically induced pain and heat pain (P≤0.001).Relative to habitual sleep, electrically induced pain increased by 22.3% and heat pain increased by 26.5%. The sensitivity to cold and pressure pain did not change, changes relative to habitual sleep was <5% (P>0.5). Pain inhibition was 66.9% stronger after NSW versus after habitual sleep (P<0.001). Sleepiness (measured with the Karolinska Sleepiness Scale) increased from 4.1 after habitual sleep to 6.9 after NSW (P<0.001). Vigilance decreased after NSW, measured as a 0.03-second decrease in reaction time (P<0.005).Conclusions Changes in pain sensitivity after NSW is measurable with clinically relevant effect sizes and may be an important marker for studies comparing the physiological effects of different shift work schedules. Explanations for the differential effect on different pain modalities should be a focus for future studies.

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confidence: 74%

Night-shift work is associated with increased pain perception

Matre

Knardahl²,

Nilsen³

2017

Scand J Work Environ Health

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“…Self reported sleep disruption and/or insomnia have been linked to increased pain, changes in affect, and higher fatigue in patients with rheumatoid arthritis (Nicassio and Wallston 1992), bedpartners of men who have OSA (Smith et al 2009) and healthy adults (Buysee et al 2007;Totterdell et al 1994;Zohar et al 2005). Moreover, experimental partial and total sleep deprivation, as well as selective deprivation of REM and SWS sleep have been shown to substantially reduce pain thresholds and tolerance in healthy adults (e.g., Kunderman et al 2004;Onen et al 2001;Roehrs et al 2006). Chronic sleep deprivation is likely to be more troubling than acute sleep problems.…”

Section: Pain Fatigue and Dysphoric Moodmentioning

confidence: 97%

The Role of Sleep and Attention in the Etiology and Maintenance of Fibromyalgia

et al. 2011

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Fibromyalgia (FM) is a prevalent, debilitating condition characterized by widespread, intense pain experienced as emanating from in the muscles, tendons, and ligaments. Other symptoms include disabling fatigue, poor sleep quality, gastrointestinal complaints, cognitive difficulties and often depression. Lack of apparent muscle pathology or other obvious physiological causes of FM pain make the etiology of FM unclear. This manuscript reviews extant FM literature and integrates research on sleep and the burgeoning literature from the domain of cognitive neuroscience to formulate the Sleep and Pain Diatheses (SAPD) model of FM. This model proposes that a wide range of biopsychosocial stressors can set the stage for FM by activating diatheses for sleep disruption and pain sensitivity. Sleep disruption in those most sensitive to pain initiates a cascade of symptoms that are codified as FM. Once this process is initiated, the symptoms of FM are perpetuated and aggravated by increased vigilance to a broad range of threat-related biopsychosocial stimuli. Thus, it is proposed that sleep is integral to the etiology of FM and also energizes a cognitive feedback loop that maintains or amplifies symptom severity over time.

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“…Kundermann et al [36] assigned 24 healthy people to 2 nights of total sleep deprivation (i.e., no sleep) with a recovery sleep night in between, or a control condition (no sleep deprivation). The individuals who had been sleep deprived showed significant decreases in heat pain thresholds that were normalized after the restored sleep.…”

Section: Human Datamentioning

confidence: 99%

Do Sleep Disorders Contribute to Pain Sensitivity?

Okifuji

Hare

2011

Curr Rheumatol Rep

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Sleep disturbance is one of the most common comorbid problems for chronic pain patients. The association between the two phenomena has long been recognized, but the nature of the relationship is not well-understood. Many agree that the relationship is likely bidirectional. In this review, we focus on one side of the relationship: whether and how disordered sleep adversely impacts pain. We discuss the available evidence from the epidemiologic, clinical, and human, as well as infrahuman laboratory studies. Generally, the literature supports the positive relationship between poor sleep and increased pain. Sleep deprivation also seems to attenuate analgesic effects of medications. Research delineating the causal or associative relationship between sleep and pain is still preliminary at this time. Continuing efforts in both experimental and clinical research are needed to develop a translationally meaningful understanding of how poor sleep impacts pain.

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Sleep Deprivation Affects Thermal Pain Thresholds but Not Somatosensory Thresholds in Healthy Volunteers

Abstract: The present findings suggest that sleep deprivation produces hyperalgesic changes that cannot be explained by nonspecific alterations in somatosensory functions.

Cited by 183 publications

References 25 publications

Night-shift work is associated with increased pain perception

Night-shift work is associated with increased pain perception

The Role of Sleep and Attention in the Etiology and Maintenance of Fibromyalgia

Do Sleep Disorders Contribute to Pain Sensitivity?

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