Sleep convulsive seizures predict lack of remission in genetic generalized epilepsies: A retrospective study from a single epilepsy center in Egypt

Ashmawi, Ayman; Hosny, Hossam; Gadallah, Mohsen; Beghi, Ettore

doi:10.1111/ane.12769

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Sillanpää and Schmidt also stated that patients with cluster of seizures are more liable for drugresistant epilepsy [12]. Nocturnal seizures were statistically significant for an unfavorable outcome in our study, similarly, a large epilepsy center in Cairo had concluded that sleep convulsive seizure was an independent predictor of lack of 5 years remission in patients with genetic generalized epilepsy [13].…”

Section: Discussionsupporting

confidence: 75%

Genetic generalized epilepsy: factors associated with drug resistance polytherapy

Hosny

Elfayoumy

Adly

et al. 2023

Egypt J Neurol Psychiatry Neurosurg

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Background Different studies investigating generalized genetic epilepsy (GGE) have shown that achieving 5 years of remission, early seizure remission, and needing antiseizure medication (ASM) monotherapy may predict favorable long-term outcomes. Results This is a retrospective analytical cohort study. Records of patients with GGE diagnoses at a large epilepsy center in Cairo served as the data source. 630 patients (297 male patients (47.1%) and 333 female (52.9%)) were included, their median onset age was 13 years. The follow-up period of this study was at least 4 years. 418 patients (66.1%) were early remitters, 160 patients (25.4%) were late remitters, and 52 patients (8.3%) were intractable. In addition, 367 patients (58.3%) needed a single ASM to achieve a maximum remission period (monotherapy group), while 263 patients (41.7%) needed ASM polytherapy. Stepwise regression analysis revealed that absence seizures, clusters of seizures, seizure frequency before treatment, and dose of sodium valproate (VPA) until the first remission were independent predictors for polytherapy. Moreover, absence seizures, seizure frequency before treatment, VPA dose, and catamenial seizures in females were independent predictors of intractability. Conclusion The majority of GGE have a favorable outcome, some clinical features could predict the need for polytherapy and failure of remission on treatment.

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Section: Discussionsupporting

confidence: 75%

Genetic generalized epilepsy: factors associated with drug resistance polytherapy

Hosny

Elfayoumy

Adly

et al. 2023

Egypt J Neurol Psychiatry Neurosurg

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Absence seizures during sleep in childhood absence epilepsy: A sign of drug resistance?

Liu

Kun

2022

Brain and Development

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Control de crisis con ácido valproico, lamotrigina o levetiracetam en el manejo de la epilepsia mioclónica juvenil farmacorresistente. Revisión sistemática y metaanálisis

Zapata

Berruecos

Sanchez

et al. 2022

Neurología Argentina

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Sleep convulsive seizures predict lack of remission in genetic generalized epilepsies: A retrospective study from a single epilepsy center in Egypt

Abstract: Prolonged remission of GGEs is high and compatible with treatment discontinuation. Sleep seizures are negative prognostic predictors.

Cited by 4 publications

References 30 publications

Genetic generalized epilepsy: factors associated with drug resistance polytherapy

Genetic generalized epilepsy: factors associated with drug resistance polytherapy

Absence seizures during sleep in childhood absence epilepsy: A sign of drug resistance?

Control de crisis con ácido valproico, lamotrigina o levetiracetam en el manejo de la epilepsia mioclónica juvenil farmacorresistente. Revisión sistemática y metaanálisis

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