Sleep Characteristics in Early Stages of Chronic Kidney Disease in the HypnoLaus Cohort

Ogna, Adam; Ogna, Valentina Forni; Haba‐Rubio, José; Tobback, Nadia; Andries, Daniela; Preisig, Martin; Tafti, Mehdi; Vollenweider, Péter; Waeber, Gérard; Marques‐Vidal, Pedro; Heinzer, Raphaël

doi:10.5665/sleep.5660

Cited by 56 publications

(54 citation statements)

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“…In our dataset, depressive symptoms were not associated with decreased SWS among kTx recipients. There has been a growing interest in detailed assessment of sleep among patients with various stages of CKD [52][53][54] and there is an increasing focus on patient-reported outcomes. 55 However, these earlier studies were performed using in-home PSG and did not particularly focus on kTx recipients.…”

Section: Discussionmentioning

confidence: 99%

“…57 Interestingly, the proportion of REM sleep was also associated with declining renal function in patients with CKD, however, this association diminished after controlling for covariables. 54 Depressive symptoms were not considered in any of the previously mentioned studies.…”

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confidence: 99%

“…eGFR is reportedly associated with sleep structure in earlier stages of CKD. 54 Fourth, we also considered sleep disorders as potential confounders while building our models. Importantly, these variables did not alter the associations we report.…”

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confidence: 99%

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Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Rónai

Szentkirályi

Lázár

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives: Both depression and sleep complaints are very prevalent among kidney transplant (kTx) recipients. However, details of the complex relationship between sleep and depression in this population are not well documented. Thus, we investigated the association between depressive symptoms and sleep macrostructure parameters among prevalent kTx recipients. Methods: Ninety-five kTx recipients participated in the study (54 males, mean ± standard devation age 51 ± 13 years, body mass index 26 ± 4 kg/m 2 , estimated glomerular filtration rate 53 ± 19 ml/min/1.73 m 2 ). Symptoms of depression were assessed by the Center for Epidemiologic Studies -Depression Scale (CES-D). After 1-night polysomnography each recording was visually scored and sleep macrostructure was analyzed. Results: The CES-D score was significantly associated with the amount of stage 2 sleep (r = 0.20, P < .05), rapid eye movement (REM) latency (r = 0.21, P < .05) and REM percentage (r = −0.24, P < .05), but not with the amount of slow wave sleep (r = −0.12, P > .05). In multivariable linear regression models the CES-D score was independently associated with the amount of stage 2 sleep (β: 0.205; confidence interval: 0.001-0.409; P = .05) and REM latency (β: 0.234; confidence interval: 0.001-0.468; P = .05) after adjustment for potential confounders. I NTRO DUCTI O NDepression is one of the most prevalent mental health conditions in patients with chronic kidney disease (CKD) [1][2][3][4] ; furthermore, it is an important determinant of impaired quality of life. 5,6 Among kidney transplant (kTx) recipients, depression is associated with reduced adherence and also with increased morbidity, graft loss, and mortality. [7][8][9][10][11][12][13] Poor sleep and various sleep problems are also frequent complaints among kTx recipients.14,15 Earlier we reported that chronic insomnia was independently associated with the presence of depression in kTx recipients. 16 In the general population there is a strong and bidirectional relationship between depression and sleep.17 This is also reflected in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition definition of major depression (MD), 18 as sleep complaints are core symptoms of MD. Several objective sleep parameters are different in patients with MD than in healthy control patients. Patients with MD have decreased amounts of slow wave sleep (SWS) and shortened rapid eye movement (REM) latency with increased amounts of REM sleep. The exact mechanisms and factors that may link depression to poor clinical outcomes among kTx recipients are not yet well defined. In a recent review focusing on kTx and depression, 23 sleep is not mentioned. This may be due to the complete lack of polysomnography (PSG) studies that assess the association between sleep and depression in this population. The frequent co-occurrence of subjective sleep complaints and depression among kTx recipients 16 suggests that the relationship between the two conditions may be similar to the association described in the g...

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Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Rónai

Szentkirályi

Lázár

et al. 2017

Journal of Clinical Sleep Medicine

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“…Ogna et al [1] studied sleep characteristics in patients with early-stage chronic kidney disease which examine the association of kidney function and sleep. OSA diagnosis was based on home sleep recordings, and only patients with moderate and severe OSA were included in data analysis.…”

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Renal functions in obstructive sleep apnea patients

Uyar

2017

Sleep Breath

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“…I think that comprehensive analyses with enough number of subjects would make stable risk assessment possible. On this point, Ogna et al evaluated the association between early stages of CKD and sleep disordered breathing (SDB), restless legs syndrome (RLS), and subjective and objective sleep quality (SQ) in 1760 adults with sleep polysomnography at home [2]. They adopted multivariate logistic or linear regression analyses.…”

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confidence: 99%

Renal function in patients with obstructive sleep apnea

Kawada

2017

Sleep Breath

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Sleep Characteristics in Early Stages of Chronic Kidney Disease in the HypnoLaus Cohort

Abstract: Patients with early stages of CKD have impaired SQ, use more hypnotic drugs, and have an increased prevalence of SDB and PLM. After controlling for confounders, objective SQ and PLMI were still independently associated with declining kidney function.

Cited by 56 publications

References 54 publications

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Renal functions in obstructive sleep apnea patients

Renal function in patients with obstructive sleep apnea

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