Sleep, awakenings, and insulin-like growth factor-I modulate the growth hormone (GH) secretory response to GH-releasing hormone.

Abstract

To delineate possible factors influencing the magnitude of the GH response to GH-releasing hormone (GHRH), eight young healthy men participated in seven 16-h studies involving saline infusions or injections of 0.3 micrograms/kg GHRH at various times of day and stages of sleep. GH responses were quantified by deconvolution, a procedure allowing for secretory rates to be estimated from peripheral levels. While the plasma responses were monophasic, deconvolution revealed that the secretory response to GHRH generally included several distinct bursts in rapid succession. The intersubject variability of GH responses was very wide, but for a given subject, the response was quite reproducible (mean +/- SEM coefficient of variation, 21 +/- 3%). When GHRH was given during the waking period, the magnitude of the response was directly related to the amount of spontaneous GH secretion, negatively correlated with circulating levels of insulin-like growth factor-I (IGF-I) and was not influenced by time of day. When GHRH was given during slow wave sleep, the magnitude of the response was enhanced. When GHRH was given during rapid eye movement sleep, the response was similar to that observed during wake. Awakenings during sleep consistently inhibited the secretory response to GHRH, and resumption of sleep was associated with a reappearance of the secretory process. Thus, in normal men of similar age and body weight, the GH response to GHRH is dependent on the sleep or wake condition, circulating levels of IGF-I, and, possibly, genetic and lifestyle factors.

Effects of sleep deprivation on wound healing

“…The processes of inflammation and cell proliferation are regulated by polypeptide growth factors and cytokines, many of which can be affected by sleep deprivation. For example, sleep loss leads to decreased secretion of GH (Van Cauter et al. , 1992), and increased release of proinflammatory cytokines such as IL‐1 and TNF (Krueger et al.…”

“…Sleep deprivation, on the other hand, has significant effects on a number of parameters that could negatively impact the healing process. Systemic effects of total sleep deprivation include reductions in growth hormone secretion (Van Cauter et al. , 1992), increased activation of the sympathetic nervous system (Irwin et al.…”

Sindrom obstruktivnykh apnoe vo sne: sovremennye predstavleniya i rol'

“…В то же вре мя на фо не ус т ра не ния апноэ и уве ли че ния ко ли че ст ва этих ста дий сна ноч ной пик се к ре ции вос ста но вил ся. Дру гим фак то ром, обуслав ли ва ю щим на ру ше ние се к ре ции СТГ при СО АС, яв ля ет ся сни же ние чув ст ви тель но с ти к со ма то ме ди ну, что свя зы ва ют с на ру ше ни ем де я тель но с ти нерв ной си с те мы, как бы ло по ка за но E. Van Cauter и со ав то рами [34]. Вы ра бот ка ин су ли но по доб но го фак то ра рос -О б з о р л и т е р а т у р ы та-1 так же на ру ша ет ся при СО АС, при этом вы яв ля ется за ви си мость ве ли чи ны сни же ния его кон цен т рации от сте пе ни тя же с ти син д ро ма.…”

Exercise-Induced growth hormone during acute sleep deprivation

“…; Van Cauter et al. ,b). Individuals undergoing some form of sleep deprivation, such as doctors, nurses, shift workers and military personnel, offer many of our important societal services.…”