2003
DOI: 10.1046/j.1365-2796.2003.01195.x
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Sleep as restitution: an introduction

Abstract: This paper summarizes a symposium that has shown that sleep is a state of altered metabolism, and that disturbances and curtailments of sleep have far-reaching effects on endocrinology, immunology and metabolism, changes that may be linked to disease. As yet, the entire causal chain is weak but there are indications that, in particular, the risk of type 2 diabetes and cardiovascular disease may result from disturbed sleep. It is hypothesized that both insulin resistance and chronic low-grade inflammation may b… Show more

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Cited by 216 publications
(146 citation statements)
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“…These findings corroborate with those of the literature that show that sleep deprivation is associated with mood, tension and fatigue 14,15 , especially with the advance in age 14 . The study carried out by Faubel et al 25 found differences in mean SF-36 scores for all scale of the mental component in the adjusted analyses only in women, with a greater magnitude of association for role-emotional scale.…”
Section: Resultssupporting
confidence: 92%
See 1 more Smart Citation
“…These findings corroborate with those of the literature that show that sleep deprivation is associated with mood, tension and fatigue 14,15 , especially with the advance in age 14 . The study carried out by Faubel et al 25 found differences in mean SF-36 scores for all scale of the mental component in the adjusted analyses only in women, with a greater magnitude of association for role-emotional scale.…”
Section: Resultssupporting
confidence: 92%
“…Literature also suggests that good quality sleep provides for daily recovery from physical and mental stresses, improves mood, concentration and memory and reduces the risk of accidents 8,14,15 .…”
Section: Introductionmentioning
confidence: 99%
“…Until now, the mechanism behind the positive association between sleep restriction and fragmentation and type 2 diabetes is not entirely clear. There is evidence that sleep disorders are associated with an increase in sympathetic activity [16,17]. Sympathetic hyperactivity can alter glucose homeostasis and induce insulin resistance by increasing glycogen breakdown and gluconeogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Train drivers are required to work in a 24-hour irregular and rotating shifts, including weekends [37], and irregular shifts are related to increased fatigue level and have been correlated to higher risk of fatigue-related accidents [38]. Therefore, there is a need for an automated and non-intrusive fatigue countermeasure device for drivers in this environment.…”
Section: Discussion and Future Workmentioning
confidence: 99%