Sleep architecture and its clinical correlates in first episode and neuroleptic-naive patients with schizophrenia

Poulin, Julie; D’Aoust, Anne-Marie; Forest, Geneviève; Stip, Émmanuel; Godbout, Roger

doi:10.1016/s0920-9964(02)00346-8

Cited by 138 publications

(99 citation statements)

References 29 publications

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“…Reduced sleep spindles in schizophrenia were also reported in other studies [24][25][26], but there are earlier studies that did not find this [27][28][29].…”

Section: Sleep Abnormalities In Schizophreniasupporting

confidence: 57%

Similarities between cortical “up” states during slow wave sleep and wakefulness: the implications for schizophrenia

Vukadinovic

2012

Translational Neuroscience

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Negative and positive symptoms are defining features of schizophrenia. This illness is commonly associated with a number of cognitive and affective deficits as well as with some more specific sleep abnormalities. It has been previously proposed that psychosis and positive symptoms in schizophrenia could be understood as disorders of internal brain dynamics. This proposed disordered network interplay might be particularly displayed during sleep when modulation by the senses is at the minimum. It is argued here that sleep abnormalities in schizophrenia inform our understanding of the pathomechanisms involved in psychosis. More specifically, sleep spindle initiation in NREM sleep and the preparation of sensory pathways for upcoming motor actions during wakefulness may share a common mechanism, and this shared mechanism is suggested to be impaired in schizophrenia.

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“…Reduced sleep spindles in schizophrenia were also reported in other studies [24][25][26], but there are earlier studies that did not find this [27][28][29].…”

Section: Sleep Abnormalities In Schizophreniasupporting

confidence: 57%

Similarities between cortical “up” states during slow wave sleep and wakefulness: the implications for schizophrenia

Vukadinovic

2012

Translational Neuroscience

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“…Some early studies found no differences between patients and controls, e.g. [19] although such studies used small samples (<11) of unmedicated patients and identified NREM spindles with visual detection at a single EEG channel. In contrast, recent studies that used automated spindle detection algorithms, a larger number of EEG channels, and larger samples comprised of medicated SZ patients report a dramatic reduction of sleep spindles in SZ [20,21], providing evidence of a spindle deficit in SZ that is unlikely to be due to antipsychotic medication.…”

Section: Spectral Characteristics Of Sleepmentioning

confidence: 99%

“…Cross-sectional studies of SZ have also demonstrated a link between sleep architecture and psychopathology [41][42][43]. The link between positive symptoms and REM sleep has been of interest for decades due to similarities between dreams and psychosis [44].…”

Section: What Is the Impact Of Poor Sleep In Sz?mentioning

confidence: 99%

Sleep dysfunctions in schizophrenia: A practical review

Waters¹,

Manoach²

2012

OJPsych

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“…Early sleep EEG studies with small sample sizes reported increased (5 subjects [8]) or unmodified (6 subjects, [9]; 11 subjects, [10]) visual spindle counts in unmedicated SCZ patients compared to healthy control subjects. Spindle density and integrated spindle activity (ISA, calculated by integrating the amplitude of sleep spindle over time) were first found to be reduced on prefrontal, centroparietal, and temporal regions during the first cycle of sleep in a small group of chronic, medicated SCZ patients compared to healthy controls and subjects with a history of current or previous major depressive episode [11].…”

Section: Sleep Spindle In Sczmentioning

confidence: 99%

Sleep Spindle Deficit in Schizophrenia: Contextualization of Recent Findings

Castelnovo

D’Agostino

Casetta

et al. 2016

Curr Psychiatry Rep

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Sleep spindles are wax and waning brain oscillations at a frequency range of 11-16 Hz, lasting 0.5-2 s, that define non-rapid eye movement sleep stage 2. Over the past few years, several independent studies pointed to a decrease of sleep spindles in schizophrenia. The aim of this review is to contextualize these findings within the growing literature on these oscillations across other neuro-psychiatric disorders. Indeed, spindles reflect the coordinated activity of thalamocortical networks, and their abnormality can be observed in a variety of conditions that disrupt local or global thalamocortical connectivity. Although the broad methodological variability across studies limits the possibility of drawing firm conclusions, impaired spindling activity has been observed in several neurodevelopmental and neurodegenerative disorders. Despite such lack of specificity, schizophrenia remains the only condition with a typical late adolescence to young adulthood onset in which impaired spindling has been consistently reported. Further research is necessary to clearly define the pathogenetic mechanisms that lead to this deficit and the validity of its widespread use as a clinical biomarker.

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Sleep architecture and its clinical correlates in first episode and neuroleptic-naive patients with schizophrenia

Cited by 138 publications

References 29 publications

Similarities between cortical “up” states during slow wave sleep and wakefulness: the implications for schizophrenia

Similarities between cortical “up” states during slow wave sleep and wakefulness: the implications for schizophrenia

Sleep dysfunctions in schizophrenia: A practical review

Sleep Spindle Deficit in Schizophrenia: Contextualization of Recent Findings

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