Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia

Culebras, Antonio; Anwar, Sanam

doi:10.1007/s11910-018-0855-1

Cited by 46 publications

(30 citation statements)

References 79 publications

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“…[2] The association between oSDB and cardiovascular risk in adults is described in the literature. [3] Cicero et al described that self-reported snoring and sleep apnea were considered main independent predictors associated with higher pulse wave velocity (PWV), the gold standard for measuring arterial stiffness, and that augmentation index (AIx), an indirect index of arterial stiffness and direct left ventricular afterload, was signi cantly higher in snorers with or without apnea than in non-snorers. [4] Thus, oSDB appears to be a modi able risk factor for cardiovascular morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Pediatric obstructive sleep-disordered breathing is associated with arterial stiffness

et al. 2021

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The association between obstructive sleep-disordered breathing (oSDB) and arterial stiffness, an independent predictor of cardiovascular outcomes, is not well established in children. This study compared cardiovascular parameters between healthy and oSDB children and aimed to identify predictors of arterial stiffness indices in children with oSDB. MethodsCross-sectional study realized in a tertiary hospital from June 2018 to January 2020. 48 children (3 to 10 years old) with clinical diagnosis of oSDB and indication for adenotonsillectomy and 24 controls were evaluated. Cardiovascular parameters were measured non-invasively by brachial artery oscillometry with What Is New Children with oSDB have augmented arterial stiffness, evidenced by the increase in AIx@75, measured non-invasively by brachial artery oscillometry with a portable device.Low quality of life and therefore a high disease burden in children with oSDB may be a risk factor for arterial stiffness.

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Section: Introductionmentioning

confidence: 99%

Pediatric obstructive sleep-disordered breathing is associated with arterial stiffness

et al. 2021

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“…A study (Chang et al ., 2013) focusing on the impact of SA on the risk of developing the two most common forms of dementia, AD and VD, reported that SA could increase the risk of VD (adjust HR: 1.93, 95% CI=1.00–3.77; p <0.005). A recent study (Culebras and Anwar, 2018) further demonstrated that older women (mean age 82.3 years) with moderate to severe obstructive sleep apnea were more likely to develop mild cognitive impairment or VD (adjusted odds ratio [AOR], 1.85; 95% CI=1.11–3.08). Hypoxia is the main feature of SA affecting cognition, and microinfarcts are the major lesions of VD.…”

Section: Impact Of Sleep Disorder As a Risk Factor For Dementia In Mementioning

confidence: 97%

Impact of Sleep Disorder as a Risk Factor for Dementia in Men and Women

Jee

Shin

Jung

et al. 2020

Biomolecules & Therapeutics

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Sleep is an essential physiological process, especially for proper brain function through the formation of new pathways and processing information and cognition. Therefore, when sleep is insufficient, this can result in pathophysiologic conditions. Sleep deficiency is a risk factor for various conditions, including dementia, diabetes, and obesity. Recent studies have shown that there are differences in the prevalence of sleep disorders between genders. Insomnia, the most common type of sleep disorder, has been reported to have a higher incidence in females than in males. However, sex/gender differences in other sleep disorder subtypes are not thoroughly understood. Currently, increasing evidence suggests that gender issues should be considered important when prescribing medicine. Therefore, an investigation of the gender-dependent differences in sleep disorders is required. In this review, we first describe sex/gender differences not only in the prevalence of sleep disorders by category but in the efficacy of sleep medications. In addition, we summarize sex/gender differences in the impact of sleep disorders on incident dementia. This may help understand gender-dependent pathogenesis of sleep disorders and develop therapeutic strategies in men and women.

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“…Periods of apnea are accompanied by periods of hypoxemia and by brief electroencephalographic and autonomic arousals that lead to a disruption of normal sleep architecture [101]. OSA is associated with several chronic conditions, including depression, hypertension, risk of stroke and myocardial infarction, and cardiac arrhythmia [103][104][105][106][107]. OSA is also associated with vascular dementia and with an earlier onset of mild cognitive impairment and dementia compared with subjects without OSA [108].…”

Section: Sleep Disruption In Age-related Comorbiditiesmentioning

confidence: 99%

Sleep as a Therapeutic Target in the Aging Brain

2019

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Sleep is a behavioral phenomenon conserved among mammals and some invertebrates, yet the biological functions of sleep are still being elucidated. In humans, sleep time becomes shorter, more fragmented, and of poorer quality with advancing age. Epidemiologically, the development of age-related neurodegenerative diseases such as Alzheimer's and Parkinson's disease is associated with pronounced sleep disruption, whereas emerging mechanistic studies suggest that sleep disruption may be causally linked to neurodegenerative pathology, suggesting that sleep may represent a key therapeutic target in the prevention of these conditions. In this review, we discuss the physiology of sleep, the pathophysiology of neurodegenerative disease, and the current literature supporting the relationship between sleep, aging, and neurodegenerative disease.

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Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia

Cited by 46 publications

References 79 publications

Pediatric obstructive sleep-disordered breathing is associated with arterial stiffness

Pediatric obstructive sleep-disordered breathing is associated with arterial stiffness

Impact of Sleep Disorder as a Risk Factor for Dementia in Men and Women

Sleep as a Therapeutic Target in the Aging Brain

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