Sleep Apnea and Risk of Peptic Ulcer Bleeding: A Nationwide Population-based Study

Shiao, Tsu Hui; Liu, Chia Jen; Luo, Jiing Chyuan; Su, Kang Cheng; Chen, Yuh Min; Chen, Tzeng Ji; Chou, Kun-Ta; Shiao, Guang-Ming; Lee, Yu Chin

doi:10.1016/j.amjmed.2012.08.017

Cited by 35 publications

(39 citation statements)

References 47 publications

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“…One study reported a positive association between sleep and peptic ulcer bleeding from a nationwide population base-study18. In this study, patients with sleep apnea had a 2.4-fold higher risk for incident peptic ulcer bleeding18. Hyperactivation of the sympathetic system and increased blood pressure may have caused peptic ulcer bleeding in a manner analogous to stress ulcer formation, which may also have contributed to the increased incidence of PUD in our study1920.…”

Section: Discussionmentioning

confidence: 48%

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Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean National Health and Nutrition Examination Survey (2008–2009)

Baeg

et al. 2016

Sci Rep

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Sleep is integral to life and sleep duration is important in sleep quality, physical, and psychological health. Disturbances in sleep duration have been associated with increased risk of metabolic disorders, hypertension, and overall mortality. Sleep disturbance has also been linked with various gastrointestinal disorders. However, the association between sleep and peptic ulcer disease (PUD) has not been evaluated. We investigated the association between sleep duration and PUD. Subjects were included from the fifth Korean National Health and Nutrition Examination Survey conducted from 2008–2009. Individuals with PUD were defined as those with a physician diagnosis of PUD. Daily sleep duration was established by asking participants the amount of time that they slept per day. Multiple logistic regression models were used to evaluate the association of PUD and sleep duration. This study included 14,290 participants (8,209 women). The prevalence of PUD was 5.7% and was higher in men (6.8%) than in women (4.9%). Women who slept ≥9 hours were significantly less likely to have PUD compared to women who slept 7 hours. In men, longer sleep duration (≥9 hours) had a tendency toward PUD prevention. Our results suggest that longer sleep duration may play a protective role for PUD development.

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Section: Discussionmentioning

confidence: 48%

“…However, the association between sleep duration and PUD has not been evaluated. One study reported a positive association between sleep and peptic ulcer bleeding from a nationwide population base-study18. In this study, patients with sleep apnea had a 2.4-fold higher risk for incident peptic ulcer bleeding18.…”

Section: Discussionmentioning

confidence: 54%

Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean National Health and Nutrition Examination Survey (2008–2009)

Baeg

et al. 2016

Sci Rep

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“…Sixth, we did not stratify SA into obstructive or central types. We assumed that most patients had obstructive SA based on the literature about patients with polysomnography-confirmed SA in Taiwan, which states that only 0.8% of patients have pure central SA 18,36. Further investigation is required to elucidate whether obstructive and central SA differ in the risk of PD.…”

Section: Discussionmentioning

confidence: 99%

Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study

Chou¹,

Lai²,

Chou³

et al. 2017

NDT

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PurposeSleep apnea (SA)-induced chronic intermittent hypoxia increases oxidative stress and inflammation, which may contribute to the pathophysiology of Parkinson’s disease (PD). This study evaluated the risk of PD following SA diagnosis.Patients and methodsThis was a 3-year nationwide population-based matched cohort study using claims data from the National Health Insurance Research Database (NHIRD), Taiwan. We analyzed 1,944 patients diagnosed as having SA between 1997 and 2005 and a matched cohort of 9,720 non-SA patients from the NHIRD. Patients with a history of PD were excluded. Each patient was followed up for 3 years to evaluate subsequent PD development.ResultsOf the 11,664 patients, 17 (0.9%) and 38 (0.4%) from the SA and matched non-SA cohorts, respectively, were subsequently diagnosed as having PD during follow-up. After adjustments for potential confounders, the SA cohort had a 1.85-fold higher risk of PD than the non-SA cohort (95% confidence interval [CI] =1.02–3.35; P=0.042). After age and sex stratification, PD development was independently associated with SA only in men (adjusted hazard ratio [HR], 2.26; 95% CI =1.11–4.63; P<0.05) and in patients aged ≥60 years (adjusted HR, 1.93; 95% CI =1.01–3.71; P<0.05).ConclusionOur study suggests that patients with SA are at an increased longitudinal risk of PD. Furthermore, age and male sex are independently associated with the risk of PD.

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“…Risk of pneumonia was stratified according to the need for continuous positive airway pressure (CPAP) treatment, which was used as a surrogate marker for severity of sleep apnea. 15,20 All patients were followed Cases of disagreement were resolved by discussion. We used the consensus guidelines to identify pneumonia.…”

Section: Main Outcome Measuresmentioning

confidence: 99%

“…20 From Jan. 1, 2000, to June 30, 2009, 3766 patients with a diagnosis of sleep apnea at our hospital (ICD-9 codes 780.51, 780.53, 780.57) were evaluated. Of these, 3124 (83%) had data from overnight polysomnography (results from self-pay polysomnography or based on unattended portable devices were not included).…”

Section: Main Outcome Measuresmentioning

confidence: 99%

Sleep apnea and risk of pneumonia: a nationwide population-based study

Liu

Wang

et al. 2014

CMAJ

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129

111

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Sleep Apnea and Risk of Peptic Ulcer Bleeding: A Nationwide Population-based Study

Cited by 35 publications

References 47 publications

Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean National Health and Nutrition Examination Survey (2008–2009)

Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean National Health and Nutrition Examination Survey (2008–2009)

Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study

Sleep apnea and risk of pneumonia: a nationwide population-based study

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Sleep Apnea and Risk of Peptic Ulcer Bleeding: A Nationwide Population-based Study

Cited by 35 publications

References 47 publications

Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean National Health and Nutrition Examination Survey (2008–2009)

Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean National Health and Nutrition Examination Survey (2008–2009)

Sleep apnea and the subsequent risk of Parkinson&rsquo;s disease: a 3-year nationwide population-based study

Sleep apnea and risk of pneumonia: a nationwide population-based study

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Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study