Sleep and the metabolic syndrome

Wołk, Robert; Somers, Virend K.

doi:10.1113/expphysiol.2006.033787

Cited by 152 publications

(114 citation statements)

References 134 publications

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“…114 Finally, related metabolic dysregulation such as leptin resistance and the metabolic syndrome also have been linked to OSA. 51,115 Thrombosis OSA also been associated with increased platelet activation, increased fibrinogen, and other potential markers of thrombotic risk. 116 However, additional studies are needed to more definitively evaluate the role of hemostatic mechanisms and to confirm any hypercoagulable state in OSA.…”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

Sleep Apnea and Cardiovascular Disease

et al. 2008

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Section: Endothelial Dysfunctionmentioning

confidence: 99%

Sleep Apnea and Cardiovascular Disease

et al. 2008

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“…The mechanism could be related to increased abdominal visceral obesity altering chest wall and upper airway mechanics and reducing functional residual capacity making subjects more vulnerable to hypoxemia during sleep [24]. It has also been shown that SDB can independently induce MetS by decreasing insulin sensitivity in both animals and humans [25]. A recent study by Tasali et al in women with PCOS and SDB showed the reversal of key determinants of the MetS after 8-weeks of CPAP treatment including significant improvements in: insulin sensitivity, daytime diastolic blood pressure, heart rate variability, and daytime sleepiness [26].…”

Section: Discussionmentioning

confidence: 99%

Screening For Sleep Disordered Breathing And Excessive Daytime Sleepiness in Adolescent Girls With Polycystic Ovarian Syndrome

Nandalike

Agarwal

Coupey

et al. 2010

D74. Clinical Presentation and Epidemiology of Sleep Disordered Breathing

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Objective-To determine the prevalence and clinical and metabolic correlates of sleep disordered breathing (SDB) and excessive daytime sleepiness (EDS) in adolescent girls with polycystic ovarian syndrome (PCOS).Study design-Standardized questionnaires were administered to subjects with PCOS and age-, sex-, ethnicity-, and BMI Z-score-matched controls. Medical records were reviewed for anthropometric and metabolic data.Results-We studied 103 subjects with PCOS (16.9±1.5 years) and 90 controls (16.8±1.7 years). Compared with controls, girls with PCOS had a higher prevalence of SDB (45.6% vs. 27.8%, p=0.01) and EDS (54.4% vs.35.6%, p<0.01). Within PCOS, those with SDB had higher BMI Zscore (2.1±0.5 vs.1.7±0.6, p< 0.01), higher homeostatic model assessment (HOMA) (5.1±2.3 vs. 4.1±3.5, p<0.01), and higher prevalence of the metabolic syndrome (MetS) (42.6% vs. 16.1%, p=0.003), compared with those without SDB. Similarly, subjects with PCOS and EDS had higher BMI-Z score (2.0±0.6 vs.1.7±0.6, p=0.03), higher HOMA (5.1±2.9 vs.3.8±3.1, p=0.01), and higher rate of MetS (39.3% vs. 14.9% p<0.01), compared with those without EDS. MetS was independently associated with SDB (OR 3.2, CI-1.0-10.1) and EDS (OR 4.5, CI-1.2-16).Conclusions-SDB and EDS are highly prevalent in adolescent girls with PCOS compared with matched controls. The MetS is independently associated with SDB and EDS in this group. The preliminary results of this paper were presented at ATS 2010 International Meeting.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. In recent years, PCOS has also been recognized to be associated with sleep disordered breathing (SDB) as well as excessive daytime sleepiness (EDS) [4,5]. In fact, a prospective case-control study, estimated that women with PCOS have a 30-fold higher prevalence of SDB than women in the general population [5]. The pathophysiological mechanisms leading to such high prevalence of SDB in PCOS have not yet been defined. However, possible causes include alterations in body fat composition due to excess androgen levels and/or the effects of metabolic syndrome [4,6], the later of which has been previously associated with increased risk of SDB in patients without PCOS [7,8]. Even though SDB is very prevalent in women with the disorder, the natural history of the disorder in adolescent girls and young women is unknown, mostly due to lack of knowledge about such an association. [9]. NIH Public AccessThus, the main aims of the present study were twofold: First, to compare the prevalence of SDB and EDS among adolescent girls with PCOS with sex-, age-, race-, and BM-Z sc...

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“…A link between prolonged sleep disturbance and the increasing worldwide prevalence of the metabolic syndrome has been proposed [15,17,32]. For instance, it has been reported that clock gene expression is impaired in individuals with metabolic syndrome, and, further, that impairments in transcript levels of PER3 in human leukocytes occur in diabetic subjects and gestational diabetic women [33,34].…”

Section: Discussionmentioning

confidence: 99%

Per3 length polymorphism in patients with type 2 diabetes mellitus

Ramanujam

Marimuthu

Sooriyakumar

et al. 2013

Hormone Molecular Biology and Clinical Investigation

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Background: A number of observations support the involvement of circadian clock genes in the regulation of metabolic processes. One of these circadian genes, Per3, exhibits a variable number tandem repeat length polymorphism, consisting of two alleles, namely four and five repeat alleles, in its exon 18. The objective of this study was to examine the existence of Per3 variants in patients with type 2 diabetes mellitus (T2DM) as compared to a non T2DM control group. Methods: Intravenous blood samples were collected to obtain white blood cells from 302 T2DM patients and 330 non-diabetic, age-and sex-matched, individuals. Per3 genotyping was performed on DNA by polymerase chain reaction. Results: Frequency of five repeat allele was higher, and that of four repeat allele lower, in T2DM patients as compared to non-diabetic controls (χ 2 = 6.977, p = 0.0082) Conclusions:The results indicate an association of Per3 five repeat allele with T2DM occurrence and suggest that individuals with five repeat allele may be at a greater risk for T2DM as compared to those carrying the four repeat allele.

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Sleep and the metabolic syndrome

Cited by 152 publications

References 134 publications

Sleep Apnea and Cardiovascular Disease

Sleep Apnea and Cardiovascular Disease

Screening For Sleep Disordered Breathing And Excessive Daytime Sleepiness in Adolescent Girls With Polycystic Ovarian Syndrome

Per3 length polymorphism in patients with type 2 diabetes mellitus

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