Sleep and the functional connectome

Picchioni, Dante; Duyn, Jeff H.; Horovitz, Silvina G.

doi:10.1016/j.neuroimage.2013.05.067

Cited by 106 publications

(65 citation statements)

References 137 publications

(214 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although anesthesia alters spontaneous neural activity, recent work in mice has shown that cortical correlations in slow activity are quite stable across wake and ketamine/xylazine anesthesia states (72). This is in agreement with data showing stability of low-frequency correlation across states of consciousness in humans (73). Moreover, although the slow wave phenomenon was first reported in the context of anesthesia and slow wave sleep (74,75), recent work has also shown that slow wave propagation is also present in awake rodents (76).…”

Section: Monocular Visual Deprivation Induces Intranetwork Change In supporting

confidence: 85%

Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

Kraft

Mitra

Bauer

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Decades of work in experimental animals has established the importance of visual experience during critical periods for the development of normal sensory-evoked responses in the visual cortex. However, much less is known concerning the impact of early visual experience on the systems-level organization of spontaneous activity. Human resting-state fMRI has revealed that infraslow fluctuations in spontaneous activity are organized into stereotyped spatiotemporal patterns across the entire brain. Furthermore, the organization of spontaneous infraslow activity (ISA) is plastic in that it can be modulated by learning and experience, suggesting heightened sensitivity to change during critical periods. Here we used wide-field optical intrinsic signal imaging in mice to examine whole-cortex spontaneous ISA patterns. Using monocular or binocular visual deprivation, we examined the effects of critical period visual experience on the development of ISA correlation and latency patterns within and across cortical resting-state networks. Visual modification with monocular lid suturing reduced correlation between left and right cortices (homotopic correlation) within the visual network, but had little effect on internetwork correlation. In contrast, visual deprivation with binocular lid suturing resulted in increased visual homotopic correlation and increased anti-correlation between the visual network and several extravisual networks, suggesting cross-modal plasticity. These network-level changes were markedly attenuated in mice with genetic deletion of Arc, a gene known to be critical for activity-dependent synaptic plasticity. Taken together, our results suggest that critical period visual experience induces global changes in spontaneous ISA relationships, both within the visual network and across networks, through an Arc-dependent mechanism.infraslow activity | functional connectivity | visual critical period | activity-regulated cytoskeleton-associated protein

show abstract

Section: Monocular Visual Deprivation Induces Intranetwork Change In supporting

confidence: 85%

Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

Kraft

Mitra

Bauer

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Spontaneous activity in the infra-slow range could be modulated by behavioral state of the animal (31,48). Thus, particular propagation structures found in the present study under anesthesia, such as anterior-to-posterior propagation of GBA (see below for further discussion), could appear different in awake states.…”

Section: Discussionmentioning

confidence: 60%

Transient neuronal coactivations embedded in globally propagating waves underlie resting-state functional connectivity

Matsui

Murakami

Ohki

2016

Proc. Natl. Acad. Sci. U.S.A.

187

210

View full text Add to dashboard Cite

Resting-state functional connectivity (FC), which measures the correlation of spontaneous hemodynamic signals (HemoS) between brain areas, is widely used to study brain networks noninvasively. It is commonly assumed that spatial patterns of HemoSbased FC (Hemo-FC) reflect large-scale dynamics of underlying neuronal activity. To date, studies of spontaneous neuronal activity cataloged heterogeneous types of events ranging from waves of activity spanning the entire neocortex to flash-like activations of a set of anatomically connected cortical areas. However, it remains unclear how these various types of large-scale dynamics are interrelated. More importantly, whether each type of large-scale dynamics contributes to Hemo-FC has not been explored. Here, we addressed these questions by simultaneously monitoring neuronal calcium signals (CaS) and HemoS in the entire neocortex of mice at high spatiotemporal resolution. We found a significant relationship between two seemingly different types of large-scale spontaneous neuronal activity-namely, global waves propagating across the neocortex and transient coactivations among cortical areas sharing high FC. Different sets of cortical areas, sharing high FC within each set, were coactivated at different timings of the propagating global waves, suggesting that spatial information of cortical network characterized by FC was embedded in the phase of the global waves. Furthermore, we confirmed that such transient coactivations in CaS were indeed converted into spatially similar coactivations in HemoS and were necessary to sustain the spatial structure of Hemo-FC. These results explain how global waves of spontaneous neuronal activity propagating across large-scale cortical network contribute to Hemo-FC in the resting state.brain network | spontaneous activity | Ca imaging | optical imaging | fMRI

show abstract

“…Indeed, a recent analysis of publicly available datasets indicates that substantial portions of eyes-closed subjects fall asleep, that fewer eyes-open subjects fall asleep, and that fixating subjects rarely fall asleep (Tagliazucchi and Laufs, 2014). Since sleep entails changed patterns of neural activity, well-characterized by EEG, that are likely also detectable in resting state fMRI data (see (Picchioni et al, 2013) for review), it is important to avoid inadvertently including sleep-related state changes in data. In eyes-open and fixation scans it may be adequate simply to watch subjects to ensure that the eyes remain open.…”

Section: Obtaining Correlates Of Spontaneous Neural Activity With Fmrimentioning

confidence: 99%

Studying Brain Organization via Spontaneous fMRI Signal

Power

Schlaggar

Petersen

2014

Neuron

238

206

View full text Add to dashboard Cite

In recent years, some substantial advances in understanding human (and non-human) brain organization have emerged from a relatively unusual approach: the observation of spontaneous activity, and correlated patterns in spontaneous activity, in the “resting” brain. Most commonly, spontaneous neural activity is measured indirectly via fMRI signal in subjects who are lying quietly in the scanner, the so-called “resting state”. This Primer introduces the fMRI-based study of spontaneous brain activity, some of the methodological issues active in the field, and some ways in which resting state fMRI has been used to delineate aspects of area-level and supra-areal brain organization.

show abstract

Sleep and the functional connectome

Cited by 106 publications

References 137 publications

Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

Transient neuronal coactivations embedded in globally propagating waves underlie resting-state functional connectivity

Studying Brain Organization via Spontaneous fMRI Signal

Contact Info

Product

Resources

About