Sleep and the Endocrine System

Morgan, Dionne; Tsai, Sheila C.

doi:10.1016/j.ccc.2015.03.004

Cited by 43 publications

(21 citation statements)

References 94 publications

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“…Poor sleep quality and both short and long sleep duration have been previously associated with a lifespan reduction due to the associated deleterious effects on health and the higher risk of several diseases [ 18 , 63 ]. Sleep and S-Klotho have both been widely shown to be related to the ageing process [ 29 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ], sharing underlying mechanisms and physiological pathways such as endocrine functions and metabolism, immune response and, consequently, oxidative stress and chronic inflammation. However, the relationship between these two aged-related factors still remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Sleep and S-Klotho, therefore, share common underlying mechanisms and physiological pathways through which they are linked to the ageing process in adults, both playing a positive substantial role in the endocrine [ 32 , 35 , 36 , 37 ] and immune systems [ 38 , 39 ] and, thereby, in oxidative stress [ 33 , 40 ] and chronic inflammation [ 29 , 41 , 42 ]—The leading molecular mechanisms behind all age-related consequences [ 43 , 44 , 45 , 46 ]. Yet, the available evidence on the relationship between sleep and S-Klotho is remarkably limited.…”

Section: Introductionmentioning

confidence: 99%

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Is Sleep Associated with the S-Klotho Anti-Aging Protein in Sedentary Middle-Aged Adults? The FIT-AGEING Study

et al. 2020

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Sleep and Klotho have both been closely related to the ageing process, both playing a substantial role in the endocrine and immune systems and, thereby, in oxidative stress and chronic inflammation. However, there are no studies elucidating the relationship between sleep and Klotho. Therefore, this study investigated the association of sleep quantity and quality with the shed form of the α-Klotho gene (S-Klotho plasma levels) in sedentary middle-aged adults. A total of 74 volunteers (52.7% women; aged 53.7 ± 5.1) were recruited for the present study. Objective sleep quality parameters (total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE)) were determined using a wrist-worn accelerometer over seven consecutive days, and the subjective sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI; higher scores indicate worse sleep quality). The S-Klotho plasma levels were measured in the ethylenediaminetetraacetic acid plasma using a solid-phase sandwich enzyme-linked immunosorbent assay. Objective sleep parameters were associated with the S-Klotho plasma levels only after including the age, fat mass percentage, and lean mass index as covariates. A direct relationship was observed between the subjective sleep quality (inverse of PSQI scores) and the S-Klotho plasma levels in sedentary middle-aged adults. Improving sleep quantity and quality could be considered an anti-aging therapeutic approach for the prevention, slowing, and even reversal of the physiological decline and degenerative pathologies that are certainly related to the aging process.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is Sleep Associated with the S-Klotho Anti-Aging Protein in Sedentary Middle-Aged Adults? The FIT-AGEING Study

et al. 2020

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“…In the literature, some have linked post-traumatic stress with these metabolic diseases [59,60,61], but causality has not been established with hypertension, cardiac failure, coronary heart disease or metabolic diseases [62,63,64]. Recent literature connects mental and behavioral disorders with the proper functioning of the endocrine system.…”

Section: Discussionmentioning

confidence: 99%

Morbi-Mortality of the Victims of Internal Conflict and Poor Population in the Risaralda Province, Colombia

Rentería-Ramos

Hurtado-Heredia

Urdinola

2019

IJERPH

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This work studies the health status of two populations similar in most social and environmental interactions but one: the individuals from one population are victims of an internal armed conflict. Both populations are located in the Risaralda province, Colombia and the data for this study results from a combination of administrative records from the health system, between 2011 and 2016. We implemented a methodology based on graph theory that defines the system as a set of heterogeneous social actors, including individuals as well as organizations, embedded in a biological environment. The model of analysis uses the diagnoses in medical records to detect morbidity and mortality patterns for each individual (ego-networks), and assumes that these patterns contain relevant information about the effects of the actions of social actors, in a given environment, on the status of health. The analysis of the diagnoses and causes of specific mortality, following the Social Network Analysis framework, shows similar morbidity and mortality rates for both populations. However, the diagnoses’ patterns show that victims portray broader interactions between diagnoses, including mental and behavioral disorders, due to the hardships of this population.

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“…Second, using pharmacological manipulations of local estrogenic signaling in the preoptic area sleep nuclei, with ER antagonism and local E2 infusion, we investigated whether E2 is necessary and sufficient to induce changes in sleep-wake behavior and homeostasis. These experiments test the hypothesis that (1) E2 acting alone at the MnPN is (2)…”

Section: A Introductionmentioning

confidence: 88%

Estradiol Action at the Median Preoptic Nucleus is Necessary and Sufficient for Sleep Suppression in Female Rats

Smith

Cusmano

Phillips

et al. 2020

Preprint

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To further our understanding of how gonadal steroids impact sleep biology, we sought to address the mechanism by which proestrus levels of cycling ovarian steroids, particularly estradiol (E2), suppress sleep in female rats. We showed that steroid replacement of proestrus levels of E2 to ovariectomized female rats, suppressed sleep to similar levels as those reported by endogenous ovarian hormones. We further showed that this suppression is due to the high levels of E2 alone, and that progesterone did not have a significant impact on sleep behavior. We found that E2 action within the Median Preoptic Nucleus (MnPN), which contains estrogen receptors (ERs), is necessary for this effect; antagonism of ERs in the MnPN attenuated the E2-mediated suppression of both non-Rapid Eye Movement (NREM) and Rapid Eye Movement (REM) sleep. Finally, we found E2 action at the MnPN is also sufficient for sleep suppression, as direct infusion of E2 into the MnPN suppressed sleep. Based on our findings, we predict proestrus levels of E2 alone, acting at the MnPN, mediate sex-hormone driven suppression of sleep in female rats.

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Sleep and the Endocrine System

Cited by 43 publications

References 94 publications

Is Sleep Associated with the S-Klotho Anti-Aging Protein in Sedentary Middle-Aged Adults? The FIT-AGEING Study

Is Sleep Associated with the S-Klotho Anti-Aging Protein in Sedentary Middle-Aged Adults? The FIT-AGEING Study

Morbi-Mortality of the Victims of Internal Conflict and Poor Population in the Risaralda Province, Colombia

Estradiol Action at the Median Preoptic Nucleus is Necessary and Sufficient for Sleep Suppression in Female Rats

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