“…In a case control study, results showed stroke patients had significantly more problems in initiating sleep as compared to Zopiclone subjects (35). At the acute stage, a significant suppression of rapid eye movement (REM) sleep has been found in patients with ischemic hemispheral lesions, and after brain stem stroke, both REM and non-REM reduction are also observed (34). Recently, polysomnographic evidence has shown that the selective serotonin reuptake inhibitor citalopram alleviates the insomnia in a non-depressed stroke patient (36).…”