Sleep and stress in the acute phase of concussion in youth

Maerlender, Arthur C.; Masterson, Caitlin J.; Calvi, Jessica L.; Caze, Todd; Mathiasen, Ross; Molfese, Dennis L.

doi:10.1016/j.smhs.2020.06.003

Cited by 7 publications

(8 citation statements)

References 31 publications

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“…The studies assessed the diagnostic accuracy of 12 unique biomarkers found either in saliva (24 studies) or urine (5 studies). Only one study assessed multiple biomarkers 10. The most commonly studied biomarker was salivary microRNA which was examined in 11 studies 11–21.…”

Section: Resultsmentioning

confidence: 99%

“…The most commonly studied biomarker was salivary microRNA which was examined in 11 studies 11–21. Cortisol was assessed in four studies 10 22–24. Melatonin was assessed in three studies 10 25 26.…”

Section: Resultsmentioning

confidence: 99%

“…Cortisol was assessed in four studies 10 22–24. Melatonin was assessed in three studies 10 25 26. No other biomarker was assessed in more than two studies.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies specifically the paediatric population (≤18 years old) 10 21 25 27 28. However, 82.8% of studies included paediatric subjects.…”

Section: Resultsmentioning

confidence: 99%

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Non-invasive fluid biomarkers in the diagnosis of mild traumatic brain injury (mTBI): a systematic review

Feinberg

Mayes

Portman

et al. 2023

J Neurol Neurosurg Psychiatry

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BackgroundDespite approximately 55.9 million annual mild traumatic brain injuries (mTBIs) worldwide, the accurate diagnosis of mTBI continues to challenge clinicians due to symptom ambiguity, reliance on subjective report and presentation variability. Non-invasive fluid biomarkers of mTBI offer a biological measure to diagnose and monitor mTBI without the need for blood draws or neuroimaging. The objective of this study is to systematically review the utility of such biomarkers to diagnose mTBI and predict disease progression.MethodsA systematic review performed in PubMed, Scopus, Cochrane and Web of Science followed by a manual search of references without a specified timeframe. Search strings were generated and run (27 June 2022) by a research librarian. Studies were included if they: (1) included human mTBI subjects, (2) assessed utility of a non-invasive biomarker and (3) published in English. Exclusion criteria were (1) non-mTBI subjects, (2) mTBI not assessed separately from moderate/severe TBI, (3) required intracranial haemorrhage or (4) solely assesses genetic susceptibility to mTBI.ResultsA total of 29 studies from 27 subject populations (1268 mTBI subjects) passed the inclusion and exclusion criteria. Twelve biomarkers were studied. Salivary RNAs, including microRNA, were assessed in 11 studies. Cortisol and melatonin were assessed in four and three studies, respectively. Eight salivary and two urinary biomarkers contained diagnostic or disease monitoring capability.DiscussionThis systematic review identified several salivary and urinary biomarkers that demonstrate the potential to be used as a diagnostic, prognostic and monitoring tool for mTBI. Further research should examine miRNA-based models for diagnostic and predictive utility in patients with mTBI.PROSPERO registration numberCRD42022329293.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Cortisol was assessed in four studies 10 22–24. Melatonin was assessed in three studies 10 25 26. No other biomarker was assessed in more than two studies.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies specifically the paediatric population (≤18 years old) 10 21 25 27 28. However, 82.8% of studies included paediatric subjects.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Non-invasive fluid biomarkers in the diagnosis of mild traumatic brain injury (mTBI): a systematic review

Feinberg

Mayes

Portman

et al. 2023

J Neurol Neurosurg Psychiatry

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“…Sleep disorders reported in post-traumatic brain injury patients include insomnia and hypersomnia syndromes, circadian rhythm disorders, and sleep-related breathing disorders [107,108]. The pathophysiology may include disruption of neuronal networks involved in the regulation of the circadian rhythm, but it is also related to other post-concussion symptoms, such as pain, headache, or mood disturbances.…”

Section: Fatigue Anxiety and Sleep Disorder: How To Managementioning

confidence: 99%

Concussion Rehabilitation

2020

Frontiers Research Topics

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Concussion represents one of modern medicine's biggest challenges. As we are gaining more and more information on pathophysiology, diagnosis, and treatment, a lot is still to be cleared. On the side of pharmacology, rehabilitation is the leading treatment for concussion signs and symptoms. From acute to the chronic phase of brain dysfunction, rehabilitation is nowadays providing help to people recover faster and better. In this chapter, we will analyze in depth the key information and evidence supporting current concussion rehabilitation methods and protocols. Through this chapter, we are exploring how aerobic training, vestibular rehabilitation, and oculomotor exercises are working together with the treatment of migraine and neck pain. We also aim to provide the basis and relevance of cognitive rehabilitation and doubletask-multifunctional training and the importance of fatigue and mood problem management.

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