Sleep and seizure risk in epilepsy: Bed and wake times are more important than sleep duration

Abstract

Sleep duration, sleep deprivation and the sleep-wake cycle are thought to play an important role in the generation of epileptic activity and may also influence seizure risk. Hence, people diagnosed with epilepsy are commonly asked to maintain consistent sleep routines. However, emerging evidence paints a more nuanced picture of the relationship between seizures and sleep, with bidirectional effects between changes in sleep and seizure risk in addition to modulation by sleep stages and transitions between stages. We conducted a longitudinal study investigating sleep parameters and self-reported seizure occurrence in an ambulatory at-home setting using mobile and wearable monitoring. Forty-four subjects wore a Fitbit smartwatch for at least 28 days while reporting their seizure activity in a mobile app. Multiple sleep features were investigated, including duration, oversleep and undersleep, and sleep onset and offset times. Sleep features in participants with epilepsy were compared to a large (n=37921) representative population of Fitbit users, each with 28 days of data. For participants with at least 10 seizure days (n=29), sleep features were analysed for significant changes prior to seizure days. A total of 3894 reported seizures (M = 88, SD = 130) and 17078 recorded sleep nights (M = 388, SD = 351) were included in the study. Participants with epilepsy slept an average of 2 hours longer than the average sleep duration within the general population. Just 1 of 29 participants showed a significant difference in sleep duration the night before seizure days compared to seizure-free days. However, 11 of 29 subjects showed significant differences between either their sleep onset (bed) or offset (wake) times prior to seizure occurrence. Conversely to existing studies, the current study found oversleeping was associated with a 20% increased seizure risk in the following 48h (p < 0.01), possibly due to nocturnal seizures occurring overnight. Nocturnal seizures were associated with both significantly longer sleep durations and increased risk of a seizure occurring in the following 48h. We also observed that oversleeping only significantly contributed to seizure risk when the participant was in a high-risk state, according to a cycles-based forecasting algorithm. Overall, the presented results demonstrated that day-to-day changes in sleep-duration had a minimal effect on reported seizures, which bed- and wake-times were more important for identifying seizure risk the following day. Oversleeping was also linked to seizure occurrence, most likely due to nocturnal seizures driving oversleep. Wearables can be utilised to identify these sleep-seizure relationships and guide clinical recommendations or improve seizure forecasting algorithms.