Sleep and Quality of Life in Parkinson’s Disease

Whitehead, Daisy L.; Mitchell-Hay, Rosalind; Reddy, P. Ramakrishna; Muzerengi, Sharon

doi:10.1007/978-1-60327-343-5_20

Cited by 5 publications

(5 citation statements)

References 79 publications

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“…However, as suggested by the regression analysis, the lower QoL reported by these patients is due to other factors, such as sleep complaints and PD progression, rather than PLMS, in line with prior findings [9–12]. …”

Section: Discussionsupporting

confidence: 90%

“…Overnight polysomnographic (PSG) sleep recordings suggest frequent awakenings, low sleep efficiency (SE), decreased amount of slow wave sleep (SWS) and REM sleep, as well as increased light sleep and REM latency [6–8]. As sleep related problems affect both nocturnal sleep and daytime wakefulness, they may increase disability and further reduce quality of life (QoL) in PD patients and their caregivers [9–12]. …”

Section: Introductionmentioning

confidence: 99%

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Clinical correlates of periodic limb movements in sleep in Parkinson's disease

Covassin

Neikrug

Liu

et al. 2012

Journal of the Neurological Sciences

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Objective The aim of the current study was to investigate the frequency of periodic limb movements in sleep (PLMS) in Parkinson’s disease (PD) and their impact on nocturnal sleep and daytime functioning. Methods Forty-five PD patients (mean age 68.5±8.7 years; 32 males) underwent one night of polysomnography (PSG). Clinical assessment and questionnaires evaluating sleep disturbance and quality of life (QoL) were completed. Patients were divided into two groups based on their PLMS index (PLMSI): PLMSI ≥15 (PLMS+) and PLMSI <15 (PLMS−). Results There were 26 (57.8%) PD patients in the PLMS+ group and 19 (42.2%) patients in the PLMS− group. Subjective assessment revealed an association between PLMS+ status and greater PD symptom severity, more subjective sleep disturbance, and decreased QoL. All patients showed poor sleep, and no significant group differences were detected on PSG measures. Conclusion We observed that PLMS occurred frequently in PD and increased with more severe PD. Although PLMS did not affect objective sleep, it was associated with increased sleep complaints and reduced QoL. Overall, our findings support the association between PLMS and PD as well as the clinical relevance of sleep disturbances in PD.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Clinical correlates of periodic limb movements in sleep in Parkinson's disease

Covassin

Neikrug

Liu

et al. 2012

Journal of the Neurological Sciences

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“…The data on diagnoses were dichotomized into one variable indicating that the participant either had or did not have a diagnosis that has been associated with poor sleep. These included multiple sclerosis (de Vries, 2008); Parkinson's disease (Whitehead et al, 2008); Huntington's disorder, Shy-Drager syndrome, polysensory neuritis, amyotrophic lateral sclerosis, spinal muscular atrophy (Dauvilliers, 2007); brain and spinal cord injuries (Piper, 2008); cerebral palsy (Kotagal et al, 1994); stroke, end-stage cardiac disease (Roth, 2009;Skobel et al, 2008); COPD (Herdegen, 2006); diabetes (Skomro, 2008); chronic renal disease (Patel et al, 2008); and cancer (Paltiel & Greenwald, 2008). Illnesses associated with poor sleep also included a current diagnosis of depression (Caliyurt, 2008), which was measured by current treatment with antidepressants.…”

Section: Methodsmentioning

confidence: 99%

“…This association may be explained by disease-related pathophysiological changes, the person's emotional response to the illness experience, and/or related symptoms such as pain (Morin, Daley, & Ouellet, 2001). For example, the disease process of multiple sclerosis and Parkinson's disease alter sleep-regulating centers in the brain; this as well as illness-related muscle rigidity, pain, and depressed mood typically disrupt sleep in this patient population (de Vries, 2008;Dauvilliers, 2007;Whitehead, Mitchell-Hay, Reddy, Muzerengi, & Chaudhuri, 2008).…”

Section: Precipitating Factorsmentioning

confidence: 99%

Differences in Sleep Complaints in Adults With Varying Levels of Bed Days Residing in Extended Care Facilities for Chronic Disease Management

2010

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This cohort study examined differences in perceived insomnia and daytime sleepiness in 67 adults residing in extended care facilities for chronic disease management who had varying levels of bed days. One bed day was defined as spending 24 hours in bed. Planned pairwise comparisons, using Bonferroni adjustment, were made between participants who spent 0 (n = 21), 2 to 4 (n = 23), and 5 to 7 (n = 23) days in bed during 1 week of monitoring. Participants who spent 5 to 7 days in bed had significantly greater insomnia than those who spent 2 to 4 days in bed. No group differences were found in daytime sleepiness. Based on the findings, nurses may assess subjective insomnia and explore sleep hygiene strategies, such as increasing time out of bed with patients who have high levels of 5 to 7 bed days.

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“…However, with the rise in recognition of NMS burden among PD patients, growing number of studies discussed the impact of NMS in PD patients QoL, and deduced that NMS can cause a measurable worsening of the QoL of those individuals during their life course. [17], [18] The NMS include: depression [19], cognitive decline [20], sleep dysfunction [21], excessive daytime somnolence[22], bladder, bowel, and sexual dysfunction [23], and weight loss [24].…”

Section: Introductionmentioning

confidence: 99%

Ethnicity as a predictor of nonmotor symptoms impact on quality of life in patients with Parkinson’s disease: A systematic review

Aldeen,

Houlden,

Rizig

2023

Preprint

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BackgroundParkinson’s disease (PD) is a chronic progressive hypokinetic movement disorder characterised by rigidity, tremor, and bradykinesia in addition to multiple non-motor features. It is increasingly recognised that NMS have a substantial impact on the quality of life (QoL) of people with PD, more than motor features. The prevalence and types of these NMS vary among PD patients from different ethnic groups. Ethnicity has been postulated as a determinant of PD symptoms and quality of life of people with PD. There is paucity of data on the effect of ethnicity on (QoL) of people with PD.AimThe aim of this review is to critically evaluate the literature to (1) identify the variability of NMS that affect QoL of people with PD from different ethnicities, and (2) to examine if ethnicity could determine the impact of these NMS on the QoL of people with PD.MethodsThis review was conducted according to recommendations in preferred reporting Items for Systematic Review and Meta-Analysis (PRISMA). Search was conducted in three databases (PubMed, Ovid Embase and Scopus) in the period between March & July 2023. NMS were assessed by four scales: NMSS, NMQT, MDS-UDPRS I, and HADS. QoL was assessed by PDQ39. Ethnicity has been defined based on the country where the study has been conducted. A best-evidence synthesis was used to summarise the demographics, study designs, NMS features in each ethnic group. The impact of NMS features on QoL in different ethnic groups was assessed by comparing the power of correlations measures between NMS domains and QoL in all studies.ResultsTwenty-one studies with 4246 patients were deemed suitable to be included. Patients in the selected studies were grouped to eight ethnic populations: Caucasian, East Asian, Indian, North African, West African, Hispanic, Mediterranean, and Middle Eastern ethnicities. Heterogeneous protocols and varied statistical methodologies were used in most studies to assess the relation between NMS and QoL of people with PD. Overall depression, fatigue, and sleep and memory problems are the symptoms with the most significant impact on QoL of majority of ethnic populations. Other NMS including cardiovascular, gastrointestinal and urinary Symptoms exhibited a variability in their impact on QoL in different ethnic groups.ConclusionOur study demonstrates that ethnicity may have a significant impact on the correlation between NMS and QoL of patients with PD. There is deficiency in studies assessing the impact of PD NMS on QoL in Africans, Latin Americans, and Middle Eastern populations. Ethnicity is poorly defined and frequently unaddressed in PD studies. Large multicentre, multinational multi-ethnic studies using rigorous unified protocols are required to properly evaluate the effect of ethnicity on PD NMS. Identification of these variabilities is crucial to aid efficient health policy planning based on each population needs and optimize use of local resources.

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Sleep and Quality of Life in Parkinson’s Disease

Cited by 5 publications

References 79 publications

Clinical correlates of periodic limb movements in sleep in Parkinson's disease

Clinical correlates of periodic limb movements in sleep in Parkinson's disease

Differences in Sleep Complaints in Adults With Varying Levels of Bed Days Residing in Extended Care Facilities for Chronic Disease Management

Ethnicity as a predictor of nonmotor symptoms impact on quality of life in patients with Parkinson’s disease: A systematic review

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