Sleep and Microbiome in Psychiatric Diseases

Wagner-Skacel, Jolana; Dalkner, Nina; Moerkl, Sabrina; Kreuzer, Kathrin; Farzi, Aitak; Lackner, Sonja; Painold, Annamaria; Reininghaus, Eva; Butler, Mary I.; Bengesser, Susanne

doi:10.3390/nu12082198

Cited by 39 publications

(23 citation statements)

References 98 publications

(122 reference statements)

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“…If this is not sufficient, the use of short‐term sleeping medication or medium‐term sedating antidepressive drugs is recommended to treat sleep disturbances. Moreover, the intestinal‐brain axis is related to sleep via various mechanisms such as intestinal permeability, immune system activation, inflammation, energy harvest, and bacterial diversity (Wagner‐Skacel et al., 2020 ). Consequently, diet impacts sleep as well (St‐Onge et al., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

COVID‐19‐related fears and information frequency predict sleep behavior in bipolar disorder

et al. 2021

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Introduction The coronavirus disease (COVID‐19) pandemic and consequent restrictions including social distancing had a great impact on everyday life. To date, little is known about how the restrictions affected sleep, which is commonly disturbed in bipolar disorder (BD). The aim of this study was to elucidate sleep patterns during the pandemic in Austrian BD individuals. Methods An online survey assessed sleep with the Pittsburgh Sleep Quality Index (PSQI) and COVID‐19‐associated attitudes, fears, and emotional distress of 20 BD individuals and 19 controls (HC) during the pandemic. The survey was conducted in April 2020, when very strict regulations were declared, and repeated in May, when they were loosened. Results Individuals with BD reported overall poor sleep according to PSQI sum at both time points. Subjective sleep quality, sleep latency, daytime sleepiness, and PSQI sum were worse in individuals with BD than in HC. Individuals with BD informed themselves more frequently about pandemic‐related topics. Higher information frequency and more COVID‐19 fears (about the virus, own infection, contracting others) correlated with worse PSQI values. Regression models found in BD group that higher information frequency as well as higher COVID‐19 fears in April predicted worse sleep characteristics in May, in particular subjective sleep quality, sleep duration, sleep efficiency, and daytime sleepiness. Conclusion As sufficient sleep duration and quality are essential for well‐being and particularly important for vulnerable BD individuals, it is important that information about the pandemic is gathered to a reasonable extent and mental health professionals include COVID‐19‐related fears when currently treating BD.

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Section: Discussionmentioning

confidence: 99%

COVID‐19‐related fears and information frequency predict sleep behavior in bipolar disorder

et al. 2021

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“…For example, Bacteroidetes genera and Clostridia species both oscillate during light–dark cycles in mice, with different abundances of bacteria during the active versus rest phases [ 110 ]. Where diurnal oscillations were disrupted by deleting circadian clock genes, altering the timing of or restricting food availability, or changing the light–dark phase, the gut microbial diurnal rhythmicity was also disrupted [ 111 ]. The timing of food intake—chrono-nutrition—may therefore be an important factor in the regulation of the GM.…”

Section: Lifestyle Factors Affecting Gm and Mental Health: Diet Physi...mentioning

confidence: 99%

Drugs, Guts, Brains, but Not Rock and Roll: The Need to Consider the Role of Gut Microbiota in Contemporary Mental Health and Wellness of Emerging Adults

Lee

Walton

O’Connor³

et al. 2022

IJMS

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Emerging adulthood (ages 18–25) is a critical period for neurobiological development and the maturation of the hypothalamic–pituitary–adrenal axis. Recent findings also suggest that a natural perturbation of the gut microbiota (GM), combined with other factors, may create a unique vulnerability during this period of life. The GM of emerging adults is thought to be simpler, less diverse, and more unstable than either younger or older people. We postulate that this plasticity in the GM suggests a role in the rising mental health issues seen in westernized societies today via the gut–brain–microbiota axis. Studies have paid particular attention to the diversity of the microbiota, the specific function and abundance of bacteria, and the production of metabolites. In this narrative review, we focus specifically on diet, physical activity/exercise, substance use, and sleep in the context of the emerging adult. We propose that this is a crucial period for establishing a stable and more resilient microbiome for optimal health into adulthood. Recommendations will be made about future research into possible behavioral adjustments that may be beneficial to endorse during this critical period to reduce the probability of a “dysbiotic” GM and the emergence and severity of mental health concerns.

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“…Lactobacillus casei also stimulates gastrointestinal afferent vagal activity and inhibits stress-induced activation of cells producing pro-adrenocorticotropic hormone in the hypothalamic paraventricular nucleus in a dose-dependent manner, ameliorating somatic symptoms induced by learning stress ( Takada et al, 2016 ). As reviewed by Wagner-Skacel et al (2020) , Lactobacillus has been significantly associated with the circadian rhythm in BD patients, linking a GABA disorder caused by the gut microbiota to cognitive function in BD. Thus, the gut microbiota may affect the GABA system mostly through the intestinal vagus nerve and modulate stress-related behavioral and cognitive functions in BD patients.…”

Section: The Role Of Gastrointestinal Hormones and Neurotransmitters ...mentioning

confidence: 99%

Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence

et al. 2022

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Recent studies have reported that the gut microbiota influences mood and cognitive function through the gut-brain axis, which is involved in the pathophysiology of neurocognitive and mental disorders, including Parkinson’s disease, Alzheimer’s disease, and schizophrenia. These disorders have similar pathophysiology to that of cognitive dysfunction in bipolar disorder (BD), including neuroinflammation and dysregulation of various neurotransmitters (i.e., serotonin and dopamine). There is also emerging evidence of alterations in the gut microbial composition of patients with BD, suggesting that gut microbial dysbiosis contributes to disease progression and cognitive impairment in BD. Therefore, microbiota-centered treatment might be an effective adjuvant therapy for BD-related cognitive impairment. Given that studies focusing on connections between the gut microbiota and BD-related cognitive impairment are lagging behind those on other neurocognitive disorders, this review sought to explore the potential mechanisms of how gut microbial dysbiosis affects cognitive function in BD and identify potential microbiota-centered treatment.

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Sleep and Microbiome in Psychiatric Diseases

Cited by 39 publications

References 98 publications

COVID‐19‐related fears and information frequency predict sleep behavior in bipolar disorder

COVID‐19‐related fears and information frequency predict sleep behavior in bipolar disorder

Drugs, Guts, Brains, but Not Rock and Roll: The Need to Consider the Role of Gut Microbiota in Contemporary Mental Health and Wellness of Emerging Adults

Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence

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