Sleep and homeostatic control of plasticity

Lanza, Giuseppe; DelRosso, Lourdes M.; Ferri, Raffaele

doi:10.1016/b978-0-12-819410-2.00004-7

Cited by 41 publications

(25 citation statements)

References 183 publications

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“…Insufficient sleep increases sleep pressure, thus results in a lot of sleep debt. This might affect behavior and cognitive functions of children (41,42). The causal relationship between short sleep duration and SSBs consumption has yet to be clarified.…”

Section: Discussionmentioning

confidence: 99%

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The Association Between Frequent Sugar-Sweetened Beverage Intake and Sleep Duration in School Children: A Cross-Sectional Study

Shih

Pan

et al. 2022

Front. Nutr.

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BackgroundHigher consumption of sugar-sweetened beverages (SSBs) maybe association with children's sleep pattern. However, few studies have considered this association in Asia, especially in school children. This study investigated the relationship between children's consumption frequency of such beverages and their sleep duration.MethodsParticipants aged 6–12 years were analyzed from two survey data in 2012 and 2013–2016 Nutrition and Health Surveys in Taiwan. A total of 2,628 participants were included in the analysis (2012, N = 1,267; 2013–2016, N = 1,361). Beverages weekly consumption were divided into low and high intake groups by medians cut-off points. The sleep variables were the sleep duration at night (including school days and weekends) and sleep debt. After controlling the confounders, the correlation between sugar-sweetened beverage consumption and sleep duration was examined using multinomial logistic regression analysis.ResultsThe students slept for an average of 8.8 h on school days and 9.7 h on weekends. Relative to the low SSB intake group, the high intake group exhibited shorter sleep durations on school days (P < 0.001), greater sleep debt (P = 0.049). In logistic regression, high intake group were more likely to sleep for <8.5 h on school days (OR = 1.67, P = 0.002) and exhibit >2 h of sleep debt than low intake group (OR = 1.41, P = 0.022).ConclusionsChildren who had consumed sugar-sweetened beverages frequently slept for shorter durations at night on school days and exhibited greater sleep debt. The causal relationship was not clear. Nonetheless, these two factors are important in promoting children health.

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Section: Discussionmentioning

confidence: 99%

“…Insufficient sleep increases sleep pressure, thus results in a lot of sleep debt. This might affect behavior and cognitive functions of children ( 41 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

The Association Between Frequent Sugar-Sweetened Beverage Intake and Sleep Duration in School Children: A Cross-Sectional Study

Shih

Pan

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

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“…In the acute stage, state fragmentation presents as many short sleep episodes that are widely distributed across the 24-hour period [18], indicating possible disturbances in both the homeostatic and circadian sleep regulatory systems: changes of central melatonin release rhythms [13], as well as circadian regulation of suprachiasmatic and HPA-axis activity [37][38][39]. Although the main molecular drivers of sleep homeostasis are not yet known, in ammation has been shown to affect expression of BDNF and adenosine 2A receptors [40][41][42], both of which have been linked to sleep homeostasis [20,43].…”

Section: Discussionmentioning

confidence: 99%

Sepsis-Induced Brain State Instability

Kala

Leemburg

Ježek

2022

Preprint

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Background Sepsis-associated brain dysfunction (SABD) is a frequent severe complication of sepsis and the systemic inflammatory response syndrome. It is associated with high mortality and a majority of survivors suffer long-term neurological consequences. Sleep is commonly affected in sepsis and there is a strong correlation between its impairment and development of other complications or increased mortality in sepsis patients. Here, we investigate the effects of sepsis on brain activity patterns in order to better understand possible sources of sleep-wake disturbances associated with severe systemic inflammation. Methods We studied the effects of high LPS doses (10mg/kg) on oscillatory brain states in an acute rat model of sepsis under urethane anaesthesia, which maintains REM- and NREM sleep-like states. Twelve Long-Evans rats (6 LPS, 6 controls) were implanted with eight independently movable tetrodes in the dorsal hippocampus. Baseline LFP activity was recorded for 3 hours after saline injection, followed by another 3 hours after LPS or saline injection. REM and NREM were automatically classified based on LFP activity and quantified. Within- and between-state dynamics were analysed using a 2-D state space approach based on spectral power ratios. Aperiodic and periodic components of the power spectrum were quantified for each state. Blood serum samples and brains were collected for IL-1β quantification and histological verification of electrode placement. Results Soon after LPS injection we observed a robust fragmentation of both oscillatory states resulting in a three-fold increase in the number of state transitions that lasted for several hours, although the overall time spent in either state did not change. Analysis of power spectra showed opposing shifts in low frequency oscillations (1–9 Hz) in REM and NREM that resulted in increased similarity between both states in 2-D state space. Conclusions The observed increased spectral similarity between REM and NREM and increased instability within the states may point to a mechanism underlying the severe sleep fragmentation described both in sepsis patients and in SABD animal models.

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“…Moreover, brain iron deficiency influences the glutamatergic and adenosine systems. On one side, it leads to increased glutamatergic tone, with subsequent functional impairment of cortico-striatal-thalamic-cortical circuits in genetically vulnerable individuals ( Lanza et al, 2022 ). On the other side, brain iron deficiency decreases adenosine tone ( Lanza and Ferri, 2019 ), with subsequent dopaminergic impairment (responsible for sensorimotor dysfunction) and hyperglutamatergic tone (with subsequent hyperarousal state) ( Ferré et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%