Sleep and health-related quality of life in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction compared to the general population and patients with inguinal hernia

Marklund, Helén; Spångberg, Anders; Edéll-Gustafsson, Ulla

doi:10.3109/00365599.2010.488246

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…A study in Sweden investigated the effect of LUTS on sufferers’ sleep quality, and compared 239 men referred with LUTS, 213 men in the general population and 200 men scheduled for repair of inguinal hernia (all aged 45–80 years) . Men with LUTS had a higher prevalence of insomnia (40%) than the general population (26%) and hernia (19%) groups ( P < 0.001) and a greater proportion of men had poor sleep efficiency (defined as the ratio of reported nocturnal sleep duration and time spent in bed × 100; ≥ 85% is considered to be satisfactory) at 49% vs 39% and 31%, respectively, as assessed by the Uppsala Sleep Inventory.…”

Section: Resultsmentioning

confidence: 99%

Burden of male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) – focus on the UK

et al. 2014

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Key Messages• Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) can be bothersome and negatively impact on a patient's quality of life (QoL).• As the prevalence of LUTS/BPH increases with age, the burden on the healthcare system and society may increase due to the ageing population. This review unifies literature on the burden of LUTS/BPH on patients and society, particularly in the UK.• LUTS/BPH is associated with high personal and societal costs, both in direct medical costs and indirect losses in daily functioning, and through its negative impact on QoL for patients and partners.• LUTS/BPH is often underdiagnosed and undertreated. Men should be encouraged to seek medical advice for this condition and should not accept it as part of ageing, while clinicians should be more active in the identification and treatment of LUTS/BPH.To assess the burden of illness and unmet need arising from lower urinary tract symptoms (LUTS) presumed secondary to benign prostatic hyperplasia (BPH) from an individual patient and societal perspective with a focus on the UK. Embase, PubMed, the World Health Organization, the Cochrane Database of Systematic Reviews and the York Centre for Reviews and Dissemination were searched to identify studies on the epidemiological, humanistic or economic burden of LUTS/BPH published in English between October 2001 and January 2013. Data were extracted and the quality of the studies was assessed for inclusion. UK data were reported; in the absence of UK data, European and USA data were provided. In all, 374 abstracts were identified, 104 full papers were assessed and 33 papers met the inclusion criteria and were included in the review. An additional paper was included in the review upon a revision in 2014. The papers show that LUTS are common in the UK, affecting ≈3% of men aged 45-49 years, rising to >30% in men aged ≥85 years. European and USA studies have reported the major impact of LUTS on quality of life of the patient and their partner. LUTS are associated with high personal and societal costs, both in direct medical costs and indirect losses in daily functioning. While treatment costs in the UK are relatively low compared with other countries, the burden on health services is still substantial. LUTS associated with BPH is a highly impactful condition that is often undertreated. LUTS/BPH have a major impact on men, their families, health services and society. Men with LUTS secondary to BPH should not simply accept their symptoms as part of ageing, but should be encouraged to consult their physicians if they have bothersome symptoms.

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Section: Resultsmentioning

confidence: 99%

Burden of male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) – focus on the UK

et al. 2014

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“…The medians and quartiles (Q 1 -Q 3 ) of the IPSS were 19 (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), the SPI 16 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), the BII 7 (3-9) and the bother question in the IPSS 3 (3)(4).…”

Section: Resultsmentioning

confidence: 99%

“…Although it is known that men with LUTS have impaired health-related and disease-specific quality of life [1][2][3][4], little is known about how the men's urinary problems affect the quality of life of their partners. In a population study, both men with an enlarged prostate and with moderate to severe LUTS symptoms and their partners experienced relationship strains such as lack of physical intimacy and lack of communication [5].…”

Section: Introductionmentioning

confidence: 99%

Sleep and partner-specific quality of life in partners of men with lower urinary tract symptoms compared with partners of men from the general population

Marklund

Spångberg²,

Edéll-Gustafsson

2014

Scandinavian Journal of Urology

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“…In addition to issues of sleep quality, an increased severity of nocturia positively correlates with poorer overall health status . Patients with LUTS/BPO are also reported to have a high prevalence of insomnia and impaired QoL …”

Section: Introductionmentioning

confidence: 99%

“…6 Patients with LUTS/BPO are also reported to have a high prevalence of insomnia and impaired QoL. 7 Some previous studies showed that alpha-adrenergic antagonist, the main medical treatment for patients with LUTS/BPO, significantly improved both nocturia and sleep disorders. 8,9 However, there are few reports focusing on whether TURP, a standard surgical procedure to relieve obstruction in patients with LUTS/BPO for many decades, can improve nocturia and sleep quality.…”

Section: Introductionmentioning

confidence: 99%

Nocturia and sleep quality after transurethral resection of the prostate

Wada

Numata²,

Hou

et al. 2013

Int J of Urology

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Abbreviations & AcronymsObjectives: To evaluate the clinical efficacy of transurethral resection of the prostate on nocturia and sleep disorders in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction. Methods: A prospective multicenter study including lower urinary tract symptoms suggestive of benign prostatic obstruction patients with nocturia (twice or more) undergoing transurethral resection of the prostate was carried out. All patients were assessed using the International Prostate Symptom Score and the Pittsburgh Sleep Quality Index at baseline, and 6 months after transurethral resection of the prostate. Results: Overall, 49 patients were included in the study. A total of 20 of them (41%) had a sleep disorder defined as a score of 5.5 or more on the Pittsburgh Sleep Quality Index global score. The nocturia score significantly correlated with component 4 of the Pittsburgh Sleep Quality Index (habitual sleep efficiency). Nocturia significantly decreased after transurethral resection of the prostate from 3.0 ± 1.2 to 1.9 ± 0.8, whereas the global Pittsburgh Sleep Quality Index score did not. In 20 patients with a sleep disorder before transurethral resection of the prostate, subjective sleep quality (component 1) and habitual sleep efficiency (component 4) significantly decreased after transurethral resection of the prostate, but this was not the case for the global Pittsburgh Sleep Quality Index score. In 16 patients with a persistent sleep disorder after transurethral resection of the prostate, International Prostate Symptom Score, voiding and storage symptoms score were higher than those of patients without a sleep disorder, although the nocturia score improved equivalently in both groups. Conclusions: Transurethral resection of the prostate diminishes nocturnal urinary frequency and partly improves sleep quality in patients with nocturia and lower urinary tract symptoms suggestive of benign prostatic obstruction. A persistent sleep disorder after transurethral resection of the prostate is associated with persistent voiding and storage symptoms.

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Sleep and health-related quality of life in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction compared to the general population and patients with inguinal hernia

Abstract: Patients with LUTS suggestive of BPO had significantly impaired sleep, a higher prevalence of insomnia and significantly impaired HRQoL compared with one or both of the comparison groups.

Cited by 7 publications

References 33 publications

Burden of male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) – focus on the UK

Burden of male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) – focus on the UK

Sleep and partner-specific quality of life in partners of men with lower urinary tract symptoms compared with partners of men from the general population

Nocturia and sleep quality after transurethral resection of the prostate

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