Sleep and Cognition in Community-Dwelling Older Adults:  A Review of Literature

Brewster, Glenna; Varrasse, Miranda; Rowe, Meredeth A.

doi:10.3390/healthcare3041243

Cited by 32 publications

(35 citation statements)

References 60 publications

(146 reference statements)

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“…While a meta‐analysis of case‐control studies reported that insomnia is associated with significant impairments of small to moderate magnitude in episodic memory, problem solving, manipulation and retention in working memory, no significant group differences were observed for general cognitive function, perceptual and psychomotor processes, procedural learning, verbal functions, different dimensions of attention and some aspects of executive functioning [Fortier‐Brochu et al, ]. Furthermore, the results of studies assessing the relationship between sleep quality and cognition in community‐based samples of older adults have been highly variable, with two recent reviews highlighting the inconsistency of the literature to date [Brewster et al, ; Yaffe et al, ].…”

Section: Discussionmentioning

confidence: 99%

Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study

Sexton

Zsoldos

Filippini

et al. 2017

Human Brain Mapping

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Both sleep disturbances and decline in white matter microstructure are commonly observed in ageing populations, as well as in age‐related psychiatric and neurological illnesses. A relationship between sleep and white matter microstructure may underlie such relationships, but few imaging studies have directly examined this hypothesis. In a study of 448 community‐dwelling members of the Whitehall II Imaging Sub‐Study aged between 60 and 82 years (90 female, mean age 69.2 ± 5.1 years), we used the magnetic resonance imaging technique diffusion tensor imaging to examine the relationship between self‐reported sleep quality and white matter microstructure. Poor sleep quality at the time of the diffusion tensor imaging scan was associated with reduced global fractional anisotropy and increased global axial diffusivity and radial diffusivity values, with small effect sizes. Voxel‐wise analysis showed that widespread frontal‐subcortical tracts, encompassing regions previously reported as altered in insomnia, were affected. Radial diffusivity findings remained significant after additional correction for demographics, general cognition, health, and lifestyle measures. No significant differences in general cognitive function, executive function, memory, or processing speed were detected between good and poor sleep quality groups. The number of times participants reported poor sleep quality over five time‐points spanning a 16‐year period was not associated with white matter measures. In conclusion, these data demonstrate that current sleep quality is linked to white matter microstructure. Small effect sizes may limit the extent to which poor sleep is a promising modifiable factor that may maintain, or even improve, white matter microstructure in ageing. Hum Brain Mapp 38:5465–5473, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study

Sexton

Zsoldos

Filippini

et al. 2017

Human Brain Mapping

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“…Systematic reviews on insomnia in older adults likewise conclude that the relationship of cognition and cognitive decline with complaints is inconsistent, in contrast to their relatively consistent relationship with sleep duration, sleep fragmentation, and sleepdisordered breathing (446). Moreover, in the studies that did find worse cognitive performance in insomnia, results might have been secondary to short sleep depressive symptoms, undiagnosed sleep apnea and other medical conditions (57).…”

Section: Objectively Assessed Daytime Cognitive and Emotional Functiomentioning

confidence: 99%

Brain mechanisms of insomnia: new perspectives on causes and consequences

Someren

2021

Physiological Reviews

256

179

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While insomnia is the second most common mental disorder, progress in our understanding of underlying neurobiological mechanisms has been limited. The present review addresses the definition and prevalence of insomnia and explores its subjective and objective characteristics across the 24-hour day. Subsequently, the review extensively addresses how the vulnerability to develop insomnia is affected by gene variants, early life stress and major life events and brain structure and function. Further supported by the clear mental health risks conveyed by insomnia, the integrated findings suggest that the vulnerability to develop insomnia could rather be found in brain circuits regulating emotion and arousal than in circuits involved in circadian and homeostatic sleep regulation. Finally, a testable model is presented. The model proposes that in people with a vulnerability to develop insomnia, the locus coeruleus is more sensitive to - or receives more input from - the salience network and related circuits, even during REM sleep, when it should normally be sound asleep. This vulnerability may ignite a downwards spiral of insufficient overnight adaptation to distress, resulting in accumulating hyperarousal which in turn impedes restful sleep and moreover increases the risk of other mental health adversity. Sensitized brain circuits are likely to be subjectively experienced as "sleeping with one eye open". The proposed model opens up the possibility for novel intervention studies and animal studies, thus accelerating the ignition of a neuroscience of insomnia, which is direly needed for better treatment.

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“…Aging changes the typical rhythm of sleep. Approximately 50 percent of the elderly suffer from sleep problems such as reduction in duration of total sleep time, decreased efficiency of sleeping, and initial and late insomnia (Brewster et al, 2015; Wang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Relationship between sleep quality and mental health according to demographics of 850 patients with chronic obstructive pulmonary disease

et al. 2017

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We aimed to study sleep problems in hospitalized chronic obstructive pulmonary disease patients and assess the relationship of sleep quality with mental health and demographics of patients. Our study sample consisted of 850 chronic obstructive pulmonary disease patients hospitalized in Masih Daneshvari Hospital. Demographic data were collected and the Pittsburgh Sleep Quality and mental health questionnaires were filled out for patients. The results showed that 5.9 percent were suffering from severe sleep problems, while 4.7 percent had severe mental problems. A strong positive correlation was found between the total scores of mental health and sleep quality ( p < 0.01). The prevalence of sleep and mental health problems was higher in females compared to males. Mental health and sleep quality play important roles in quality of life of chronic obstructive pulmonary disease patients.

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Sleep and Cognition in Community-Dwelling Older Adults: A Review of Literature

Cited by 32 publications

References 60 publications

Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study

Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study

Brain mechanisms of insomnia: new perspectives on causes and consequences

Relationship between sleep quality and mental health according to demographics of 850 patients with chronic obstructive pulmonary disease

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