Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection

Taylor, Lewis; Lendenfeld, Felix von; Ashton, Anna; Sanghani, Harshmeena; Pretoro, Simona Di; Usselmann, Laura; Veretennikova, Maria; Dallmann, Robert; McKeating, Jane A.; Vasudevan, Sridhar; Jagannath, Aarti

doi:10.1016/j.isci.2022.105877

Cited by 10 publications

(8 citation statements)

References 105 publications

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“…Circadian disruption altered the lung transcriptome in mice, which predisposes animals to viral infection, including coronavirus SARS-CoV-2 [ 101 ]. SARS-CoV-2 enters cells through the angiotensin-converting enzyme type 2 receptor, which is expressed rhythmically and controlled by posttranscriptional circadian mechanisms.…”

Section: Interplay Between Clocks and Pathogens In Different Host Nichesmentioning

confidence: 99%

“…Blood: dengue virus [46], HIV [74][75][76][77], Leishmania [78], Plasmodium [86][87][88][89][90], Trypanosoma [91,92]. Respiratory tract: Aspergillus fumigatus [109,110], influenza virus [31,[97][98][99][100], respiratory syncytial virus [104], SARS-CoV-2 [101][102][103], Sendai virus [98], Streptococcus pneumoniae [107,108]. Reproductive and urinary system: Candida albicans [129], Chlamydia muridarum [124][125][126].…”

Section: The Livermentioning

confidence: 99%

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Crosstalk between circadian clocks and pathogen niche

Borrmann,

Rijo-Ferreira

2024

PLoS Pathog

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Circadian rhythms are intrinsic 24-hour oscillations found in nearly all life forms. They orchestrate key physiological and behavioral processes, allowing anticipation and response to daily environmental changes. These rhythms manifest across entire organisms, in various organs, and through intricate molecular feedback loops that govern cellular oscillations. Recent studies describe circadian regulation of pathogens, including parasites, bacteria, viruses, and fungi, some of which have their own circadian rhythms while others are influenced by the rhythmic environment of hosts. Pathogens target specific tissues and organs within the host to optimize their replication. Diverse cellular compositions and the interplay among various cell types create unique microenvironments in different tissues, and distinctive organs have unique circadian biology. Hence, residing pathogens are exposed to cyclic conditions, which can profoundly impact host–pathogen interactions. This review explores the influence of circadian rhythms and mammalian tissue-specific interactions on the dynamics of pathogen–host relationships. Overall, this demonstrates the intricate interplay between the body’s internal timekeeping system and its susceptibility to pathogens, which has implications for the future of infectious disease research and treatment.

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Section: Interplay Between Clocks and Pathogens In Different Host Nichesmentioning

confidence: 99%

Section: The Livermentioning

confidence: 99%

Crosstalk between circadian clocks and pathogen niche

Borrmann,

Rijo-Ferreira

2024

PLoS Pathog

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“…Finally, the time of day that DCs arrive in the lymph nodes also seems to matter in terms of the amount of antigen-specific CD8 + T cell proliferation induced (108,109). This effect requires genetically intact molecular clocks in both naling regulators, chemokine receptors, and leukocyte migration, while transcripts that promote viral replication and immune evasion were enhanced (100). A separate study showed that Bmal1 deficiency and sleep suppression were associated with decreased monocyte trafficking to the circulation (101).…”

Section: Central and Peripheral Pacemakersmentioning

confidence: 99%

Circadian immunity from bench to bedside: a practical guide

Mok,

Ostendorf,

Ganninger

et al. 2024

Journal of Clinical Investigation

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“…Importantly, knockout of clock genes in mouse models increases proinflammatory cytokine levels, perturbs immune cell function and trafficking ( 219 ), and promotes the replication of a wide range of viruses ( 234 , 235 ). Sleep disruption also leads to immune dysfunction, reducing natural killer cell activity ( 236 ), modifying proinflammatory cytokine production ( 70 , 237 , 238 ), and altering immune-related gene expression in multiple tissues ( 239 ), including the mouse brain ( 240 ), liver ( 241 ), and lung ( 69 , 242 ). A similar disruption of the circadian clock and immune system is seen in blood samples from sleep-deprived human subjects ( 243 , 244 ).…”

Section: The Physiological Roles Of Salt-inducible Kinasesmentioning

confidence: 99%

The multiple roles of salt-inducible kinases in regulating physiology

Jagannath

Taylor

et al. 2023

Physiological Reviews

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Salt-Inducible kinases, which comprise a family of three homologous serine-threonine kinases were first described for their role in sodium sensing, but have since been shown to regulate multiple aspects of physiology. These kinases are activated or deactivated in response to extracellular signals that are cell surface receptor mediated, and go on to phosphorylate multiple targets including the transcription co-factors CRTC1-3 and the Class IIa histone deacetylases (HDACs). Thus, the SIK family conveys signals about the cellular environment to reprogram transcriptional and post-transcriptional processes in response. In this manner, SIKs have been shown to regulate metabolic responses to feeding/fasting, cell division and oncogenesis, inflammation, and immune responses and most recently, sleep and circadian rhythms. Sleep and circadian rhythms are master regulators of physiology and are exquisitely sensitive to regulation by environmental light, and physiological signals such as need for sleep. Salt-Inducible kinases have been shown to be central the molecular control of both these processes. Here we summarise the molecular mechanisms by which SIKs control these different domains of physiology and highlight where there is mechanistic overlap with sleep/circadian rhythm control.

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Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection

Cited by 10 publications

References 105 publications

Crosstalk between circadian clocks and pathogen niche

Crosstalk between circadian clocks and pathogen niche

Circadian immunity from bench to bedside: a practical guide

The multiple roles of salt-inducible kinases in regulating physiology

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