Sleep and circadian rhythm disruption by NPTX2 loss of function
Seung-Eon Roh,
Meifang Xiao,
Ana Delgado
et al.
Abstract:Sleep and circadian rhythm disruption (SCRD) is commonly observed in aging, especially in individuals who experience progressive cognitive decline to mild cognitive impairment (MCI) and Alzheimer’s disease (AD). However, precise molecular mechanisms underlying the association between SCRD and aging are not fully understood. Orexin A is a well-characterized “sleep neuropeptide” that is expressed in hypothalamic neurons and evokes wake behavior. The importance of Orexin is exemplified in narcolepsy where it is p… Show more
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