Sleep and Antibody Response to Hepatitis B Vaccination

Abstract

Short sleep duration in the natural environment may negatively affect in vivo antibody responses to novel antigens, providing a possible explanation for observed associations of poor sleep with increased susceptibility to infectious disease.

Sleep after Vaccination Boosts Immunological Memory

“…Crosssectional and longitudinal epidemiological studies indicate that this sleep curtailment relates to negative health outcomes that may involve immune pathways (46). Interestingly, habitual short sleep duration is associated with an increased susceptibility to experimental rhinovirus infection and predicts poor Ab titers and poor clinical protection after three doses of hepatitis B vaccination in 125 middle-aged men and women (47,48). Hence, the suppressing effects of acute experimental sleep loss on immunological memory formation observed in the current study seem to apply also to natural variations in sleep, underscoring the clinical relevance of our findings.…”

Genetic and Immunologic Aspects of Sleep and Sleep Disorders

“…80 Shorter sleep duration measured by actigraphy in healthy adults was associated with an impaired IgG response to hepatitis B surface antibody and inability to achieve the threshold for clinical protection to hepatitis B vaccine despite correction for other factors. 81 In addition, response to influenza vaccine can be impaired by sleep deprivation. 82 …”

Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion

“…Studies with small numbers of subjects in both cross-sectional and experimental designs consistently demonstrate an association between short sleep duration and decreased natural killer cell function and mobilization. One observational study 29 and one controlled study 30 assessed the effect of sleep duration on immune response and vaccine clinical protection status. In both studies, shorter sleep was associated with decreased vaccine immune response.…”

“…20,21 Sleep is also critically involved in systemic physiology, including metabolism, [22][23][24][25][26] appetite regulation, 27,28 immune and hormone function, [29][30][31][32][33] and cardiovascular systems. [34][35][36][37] Sleep duration is associated with mortality risk [38][39][40] and with illnesses ranging from cardiovascular 41 and cerebrovascular 42 disease to obesity, 43 diabetes, 44 cancer, 45,46 and depression.…”