Sleep among Opioid Users

Paturi, Anil; Surani, Salim; Ramar, Kannan

doi:10.3810/pgm.2011.05.2286

Cited by 8 publications

(8 citation statements)

References 33 publications

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“…Findings in this study aligned with previous works when showing that psychological problems increased the likelihood of having poor sleep quality in MMT patients [21,41]. It might be due to the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, which was activated when patients experienced depression or stressful events in their lives such as unemployment, leading to hyperarousal, concealing slow-wave sleep (SWS) and causing poor sleep [42,43,44]. Therefore, controlling and managing psychological problems are critical to improving sleep quality of MMT patients.…”

Section: Discussionsupporting

confidence: 89%

Factors Associated with Sleep Disorders among Methadone-Maintained Drug Users in Vietnam

Lê

Dang

Tran

et al. 2019

IJERPH

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Sleep quality among heroin-dependent patients receiving methadone maintenance treatment (MMT) is not fully investigated in Vietnam. This study explored the prevalence of poor sleep quality in methadone-maintained patients and associated factors. This cross-sectional included 395 MMT patients at three clinics in Nam Dinh province, Vietnam. The Pittsburgh Sleep Quality Index (PSQI) was employed to measure patients’ sleep quality. Sociodemographic, clinical, behavioral, psychological, and social support characteristics were collected. Multivariate Logistic and Generalized Linear Regression models were applied to identify associated factors. Among 395 patients, 26.6% had poor sleep quality according to the PSQI scale. People having jobs were less likely to have poor sleep quality and lower PSQI scores compared to unemployed patients. Those having spouses had lower PSQI scores than single patients. High depression, anxiety, and stress scores were associated with poor sleep quality and high PSQI scores. A longer duration of MMT increased the likelihood of experiencing poor sleep quality. Patients smoking tobacco daily or concurrently using drugs had lower PSQI scores than those that did not. This study highlights a moderate prevalence of poor sleep quality among Vietnamese MMT patients. Regular evaluation, appropriate psychological management, and social support, as well as the provision of employment opportunities, potentially improve the sleep quality of methadone-maintained patients.

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Section: Discussionsupporting

confidence: 89%

Factors Associated with Sleep Disorders among Methadone-Maintained Drug Users in Vietnam

Lê

Dang

Tran

et al. 2019

IJERPH

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“…More chronic opioid users than non-chronic users reported initial insomnia (DFA). While participants were not specifically asked about why or when they took their analgesics (other than on a standing vs. as needed schedule), it is possible that individuals used the opioid either as a sleep aid or to help with pain experienced at sleep onset (Paturi et al ., 2011). Since opioid analgesics interrupt sleep architecture and may interfere with restorative deep sleep (Lydic and Baghdoyan, 2007), individuals who experience intermittent insomnia (SCD) and terminal insomnia (EMA) may find opioid analgesics less useful as sleep aids than those with DFA; despite an initial analgesic and hypnotic effect, opioids in these individuals may do more harm than good to sleep continuity.…”

Section: Discussionmentioning

confidence: 99%

Clinical and demographic covariates of chronic opioid and non-opioid analgesic use in rural-dwelling older adults: the MoVIES project

Karp

Lee

McGovern

et al. 2013

Int. Psychogeriatr.

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Background To describe covariates and patterns of late-life analgesic use in the rural, population-based MoVIES cohort from 1989 to 2002. Methods Secondary analysis of epidemiologic survey of elderly people conducted over six biennial assessment waves. Potential covariates of analgesic use included age, gender, depression, sleep, arthritis, smoking, alcohol, and general health status. Of the original cohort of 1,681, this sample comprised 1,109 individuals with complete data on all assessments. Using trajectory analysis, participants were characterized as chronic or non-chronic users of opioid and non-opioid analgesics. Multivariable regression was used to model predictors of chronic analgesic use. Results The cohort was followed for mean (SD) 7.3 (2.7) years. Chronic use of opioid analgesics was reported by 7.2%, while non-opioid use was reported by 46.1%. In the multivariable model, predictors of chronic use of both opioid and non-opioid analgesics included female sex, taking ≥2 prescription medications, and “arthritis” diagnoses. Chronic opioid use was also associated with age 75–84 years; chronic non-opioid use was also associated with sleep continuity disturbance. Conclusions These epidemiological data confirm clinical observations and generate hypotheses for further testing. Future studies should investigate whether addressing sleep problems might lead to decreased use of non-opioid analgesics and possibly enhanced pain management.

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“…This phenomenon may be explained by the low level of endogenous opioid peptides owing to the long-term intake of external opioid peptides (i.e., heroin and methadone) via the physiologic negative feedback inhibition loop because reduced endogenous opioid peptides could cause difficulties in sleep initiation and maintenance. [ 42 , 43 ]…”

Section: Discussionmentioning

confidence: 99%

Poor sleep quality is significantly associated with low sexual satisfaction in Chinese methadone-maintained patients

Zhang

Zhu

et al. 2017

Medicine

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Sleep disturbance negatively affects sexual function. Sleep problem and sexual dysfunction are common in methadone-maintained patients; however, their association is understudied in this patient population.This study examined the association between sleep quality and sexual satisfaction in Chinese patients receiving methadone maintenance treatment (MMT).This was a cross-sectional study. A total of 480 MMT patients who had sex with their sex partners within 1 month before the survey were recruited from 3 MMT clinics in Wuhan, China. Sexual satisfaction was assessed with a single question, and sociodemographic and clinical data were collected with a standardized questionnaire. Sleep quality was assessed with the Pittsburgh Sleep Quality Index. Multiple ordinary logistic regression was used to control for potential confounders that may bias the sleep-sexual satisfaction relationship.Sexual satisfaction scores were significantly higher in poor sleepers than normal sleepers (3.2 ± 0.9 vs. 2.8 ± 1.0, t = 4.297, P < .001). After controlling for potential confounders, results of the multiple regression analysis reveal that poor sleep quality was still significantly and independently associated with low sexual satisfaction (odd ratio = 1.58, P = .009).Poor sleep quality is significantly associated with low sexual satisfaction of methadone-maintained patients. Improving sleep quality might improve sexual satisfaction of patients receiving MMT.

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Sleep among Opioid Users

Cited by 8 publications

References 33 publications

Factors Associated with Sleep Disorders among Methadone-Maintained Drug Users in Vietnam

Factors Associated with Sleep Disorders among Methadone-Maintained Drug Users in Vietnam

Clinical and demographic covariates of chronic opioid and non-opioid analgesic use in rural-dwelling older adults: the MoVIES project

Poor sleep quality is significantly associated with low sexual satisfaction in Chinese methadone-maintained patients

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