SLC30A8 Gene rs13266634 C/T Polymorphism in Type 1 Diabetes Children of Tamil Nadu, India

Thirunavukkarasu, Ramasamy; Joseph, Asirvatham Arthur; Chitra, Ayyappan; Jayalakshmi, Mariakuttikan

doi:10.4274/jcrpe.0195

Cited by 2 publications

(3 citation statements)

References 20 publications

(25 reference statements)

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“…Single Nucleotide Polymorphism (SNP) rs13266634 C/T is known to be responsible for the altered immune response to ZnT8. In the presence of β cell dysfunction and impaired autoimmunity, this SNP displays a susceptible role in the development of T1DM [27]. SLC30A8 genotypes were strongly associated with ZnT8 autoantibodies in T1DM.…”

Section: Slc30a8mentioning

confidence: 94%

“…During the exocytosis of insulin, frequent exposure of ZnT8 antigen occurs on glucose stimulated insulin secretion. Hence, it is supposed that ZnT8 exposure can exacerbate or trigger the production of autoantibodies against ZnT8 antigens in genetically susceptible individuals [27].…”

Section: It Activates Hyperpolarization Of Membrane Potential and Decreases The Voltage-dependentmentioning

confidence: 99%

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Emerging Role of Zinc Transporter-8 Autoantibodies (ZnT8A) in Type 1 Diabetes Mellitus- A Review

Bhatty¹,

Baig²,

Zil-e-Rubab³

et al. 2019

JAMMR

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Zinc, an important micronutrient for the storage, structural stabilization, secretion and action of insulin, is present in highest concentration in pancreas. The transport of zinc occurs through the zinc transporter-8 (ZnT8) to the insulin secretory vesicles. Zinc Transporter-8 Autoantibodies (ZnT8A) has been found to be associated with Type 2 Diabetes Mellitus. Recently it is recognized as a new autoantigen in Type 1 Diabetes Mellitus (T1DM) and its autoantibodies have been found in 50-60% of individuals with T1DM. Moreover, ZnT8A exhibit humoral auto reactivity which is not displayed by any of the other islet autoantigen like glutamine decarboxylase (GAD), insulin or tyrosine phosphate-related molecules (IA-2). Immunity against ZnT8 is dependent on clinical characteristics, which may provide evidence for early recognition highlighting the importance of this transporter in the pathogenesis of T1DM. Information regarding this article was retrieved through PubMed, Google Scholar and other search engines available in the University by using the keywords zinc, ZnT, ZnT8, SLC30A8 (Solute carrier 30 member 8) and Type 1 Diabetes Mellitus. Information was gathered through original researches, reviews and epidemiological studies published up to August 2019.The aim of this review is to summarize the emerging role of ZnT8A in diagnosis and understanding the genetic basis of Type 1 Diabetes Mellitus.

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Section: Slc30a8mentioning

confidence: 94%

Section: It Activates Hyperpolarization Of Membrane Potential and Decreases The Voltage-dependentmentioning

confidence: 99%

Emerging Role of Zinc Transporter-8 Autoantibodies (ZnT8A) in Type 1 Diabetes Mellitus- A Review

Bhatty¹,

Baig²,

Zil-e-Rubab³

et al. 2019

JAMMR

View full text Add to dashboard Cite

show abstract

“…Antibodies found against these elements are good markers for T1DM. [6][7][8] In India, a study on the prevalence of GAD antibody (GADA), ZnT8, and HLA and their diagnostic values in T1DM has found a low sensitivity of GADA and ZnT8. They concluded that for diagnosing T1DM, GADA is the most superior autoantibody.…”

Section: Introductionmentioning

confidence: 99%

HLA-DQA1 and HLA-DQB1 Gene Polymorphism in Indonesian Children with Type I Diabetes Mellitus

Soetjipto¹,

Rochmah²,

Faizi³

et al. 2022

TACG

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Background: More than 40 genes influence the progression of type 1 diabetes mellitus (T1DM), including human leukocyte antigen (HLA) alleles. Different HLA genotype patterns result in diverse rates of T1DM development. HLA class II DR, DQ, and DP vary among different populations and ethnicities. Data on HLA polymorphism in T1DM in Indonesia are lacking. Therefore, this study was designed to evaluate the gene polymorphism of HLA-DQA1 and HLA-DQB1 in Indonesian children with T1DM. Patients and Methods: In this study, 31 patients with T1DM and 31 controls were enrolled from April 2020 to April 2021. This study was conducted at Dr. Soetomo Hospital, Indonesia. We evaluated the gene polymorphism of HLA-DQA1 and HLA-DQB1 using polymerase chain reaction-restriction fragment length polymorphism. The primers used were as follows: for HLA-DQA1, DQAS34: 5ʹ-GGTGTAAACTTGTACCAG-3ʹ (forward) and DQAA261: 5ʹ-ATTGGTAGCAGCGGTAGA-3ʹ (reverse); for HLA-DQB1, DQBS43: 5ʹ-TGCTACT-TCACCAA(C/T)GGG-3ʹ (forward) and DQBA249: 5ʹ-GTAGTTGTGTCTGCA (C/T)AC-3ʹ (reverse). Results:The most common HLA-DQA1 subtype in the T1DM group was 0101/0102 accounting for 67.6%, and 01/03 and 02/03 were found in the T1DM group only. Meanwhile, the most common HLA-DQB1 subtype in the T1DM group was 0301, accounting for 54.8%. Most subjects in this study were Javanese. Conclusion: HLA-DQA1 0101/0102 and HLA-DQB1 0301 were commonly found in Indonesian children with T1DM.

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SLC30A8 Gene rs13266634 C/T Polymorphism in Type 1 Diabetes Children of Tamil Nadu, India

Abstract: The present study along with the meta-analysis does not show any substantial association of the rs13266634 C/T polymorphism with T1D development.

Cited by 2 publications

References 20 publications

Emerging Role of Zinc Transporter-8 Autoantibodies (ZnT8A) in Type 1 Diabetes Mellitus- A Review

Emerging Role of Zinc Transporter-8 Autoantibodies (ZnT8A) in Type 1 Diabetes Mellitus- A Review

HLA-DQA1 and HLA-DQB1 Gene Polymorphism in Indonesian Children with Type I Diabetes Mellitus

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