SLC27 fatty acid transport proteins

Anderson, Courtney; Stahl, Andreas

doi:10.1016/j.mam.2012.07.010

Cited by 252 publications

(224 citation statements)

References 90 publications

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“…Consistent with our hepatic mRNA expression data, the protein levels of CYP8B1 and AKR1D1 were reduced in all-trans RA -treated mice. In addition, the protein level of ABCB11, a bile acid transporter [23], and SLC27A5, a very long-chain acyl-CoA synthetase [37], was also reduced by all-trans RA treatment (Fig. 4).…”

Section: Resultsmentioning

confidence: 99%

All-trans retinoic acid regulates hepatic bile acid homeostasis

Yang

Liu

et al. 2014

Biochemical Pharmacology

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Retinoic acid (RA) and bile acids share common roles in regulating lipid homeostasis and insulin sensitivity. In addition, the receptor for RA (retinoid x receptor) is a permissive partner of the receptor for bile acids, farnesoid x receptor (FXR/NR1H4). Thus, RA can activate the FXR-mediated pathway as well. The current study was designed to understand the effect of all-trans RA on bile acid homeostasis. Mice were fed an all-trans RA-supplemented diet and the expression of 46 genes that participate in regulating bile acid homeostasis was studied. The data showed that all-trans RA has a profound effect in regulating genes involved in synthesis and transport of bile acids. All-trans RA treatment reduced the gene expression levels of Cyp7a1, Cyp8b1, and Akr1d1, which are involved in bile acid synthesis. All-trans RA also decreased the hepatic mRNA levels of Lrh-1 (Nr5a2) and Hnf4α (Nr2a1), which positively regulate the gene expression of Cyp7a1 and Cyp8b1. Moreover, all-trans RA induced the gene expression levels of negative regulators of bile acid synthesis including hepatic Fgfr4, Fxr, and Shp (Nr0b2) as well as ileal Fgf15. All-trans RA also decreased the expression of Abcb11 and Slc51b, which have a role in bile acid transport. Consistently, all-trans RA reduced hepatic bile acid levels and the ratio of CA/CDCA, as demonstrated by liquid chromatography-mass spectrometry. The data suggest that all-trans RA-induced SHP may contribute to the inhibition of CYP7A1 and CYP8B1, which in turn reduces bile acid synthesis and affects lipid absorption in the gastrointestinal tract.

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Section: Resultsmentioning

confidence: 99%

All-trans retinoic acid regulates hepatic bile acid homeostasis

Yang

Liu

et al. 2014

Biochemical Pharmacology

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“…In mammalian systems, fatty acids are taken up by members of the SLC27 family [109], also known as fatty acid transport proteins (FATPs), of which there are 6 types with different expression profiles). All FATP members have a highly conserved, 311-amino acid signature sequence known as the FATP sequence.…”

Section: Fatty Acidsmentioning

confidence: 99%

Control of metabolite efflux in microbial cell factories: current advances and future prospects

Kell¹

2018

Preprint

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The yield and ease of purification of biotechnological products are typically greatly enhanced if they can be secreted into the external medium. Although not universally appreciated, however, small molecule biotechnological products do not ‘float across’ the phospholipid bilayer portion of biological membranes, and thus they need transporters to assist their passage into the extramembrane and extracellular spaces. Some of these transporters may be reversible, equilibrative transporters that might more normally be used for uptake, while others may have an efflux directionality imposed on them via suitable energy coupling mechanisms. Despite the energetic costs of small molecule synthesis, natural evolution does in fact provide a number of mechanisms by which the secretion of such products can actually enhance fitness. Where available these provide useful starting points, and assaying for such activities is crucial. In particular, in a systems biology approach, we first need to identify such/suitable activities before we can seek to increase them. They may then be improved through promoter engineering, via manipulation of control elements, or by directed evolution of the transporter proteins themselves. Modern methods of synthetic biology provide enormous opportunities for all kinds of efflux transporter engineering; they are just beginning to be realised.

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“…Brown adipocyte mitochondria also display an elevated capacity for substrate utilization, relying predominantly on the β-oxidation of long chain fatty acids (LCFA) (Sell et al, 2004). LCFA can be taken up from the circulation via fatty acid transport proteins (FATPs) or can be generated from endocytosed lipoproteins through a process mediated in part by the scavenger receptor CD36 (Anderson and Stahl, 2013; Coburn et al, 2001; Kuniyasu et al, 2002; Zeng et al, 2003). …”

Section: Introductionmentioning

confidence: 99%

Dependence of Brown Adipose Tissue Function on CD36-Mediated Coenzyme Q Uptake

et al. 2015

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Summary Brown adipose tissue (BAT) possesses the inherent ability to dissipate metabolic energy as heat through uncoupled mitochondrial respiration. An essential component of the mitochondrial electron transport chain is coenzyme Q (CoQ). While cells mostly synthesize CoQ endogenously, exogenous supplementation with CoQ has been successful as a therapy for patients with CoQ deficiency. However, which tissues depend on exogenous CoQ uptake as well as the mechanism by which CoQ is taken up by cells and the role of this process in BAT function is not well understood. Here we report that the scavenger receptor CD36 drives the uptake of CoQ by BAT and is required for normal BAT function. BAT from mice lacking CD36 displays CoQ deficiency, impaired CoQ uptake, hypertrophy, altered lipid metabolism, mitochondrial dysfunction, and defective non-shivering thermogenesis. Together, these data reveal an important new role for the systemic transport of CoQ to BAT and its function in thermogenesis.

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SLC27 fatty acid transport proteins

Cited by 252 publications

References 90 publications

All-trans retinoic acid regulates hepatic bile acid homeostasis

All-trans retinoic acid regulates hepatic bile acid homeostasis

Control of metabolite efflux in microbial cell factories: current advances and future prospects

Dependence of Brown Adipose Tissue Function on CD36-Mediated Coenzyme Q Uptake

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