RETRACTED: SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway

Xu, Liyi; Chen, Jiamin; Jia, Litao; Chen, Xiao; Moumin, Faycal Awaleh; Cai, Jianting

doi:10.1111/jcmm.16060

Cited by 52 publications

(38 citation statements)

References 56 publications

(114 reference statements)

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“…Plasma membrane transporters secure import of a wide range of substrates into the cytoplasm. Consistently, increased expression of several transporting proteins has been correlated to the increased metabolic activity of cancer cells and poor disease prognosis (Natecz, 2020 ; Sampedro-Núñez et al, 2020 ; Xu et al, 2020 ; Yamada et al, 2020 ).…”

Section: Introductionmentioning

confidence: 91%

Computational Model for Membrane Transporters. Potential Implications for Cancer

Carusela

Rubı́

2021

Front. Cell Dev. Biol.

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To explain the increased transport of nutrients and metabolites and to control the movement of drug molecules through the transporters to the cancer cells, it is important to understand the exact mechanism of their structure and activity, as well as their biological and physical characteristics. We propose a computational model that reproduces the functionality of membrane transporters by quantifying the flow of substrates through the cell membrane. The model identifies the force induced by conformational changes of the transporter due to hydrolysis of ATP, in ABC transporters, or by an electrochemical gradient of ions, in secondary transporters. The transport rate is computed by averaging the velocity generated by the force along the paths followed by the substrates. The results obtained are in accordance with the experiments. The model provides an overall framework for analyzing the membrane transport proteins that regulate the flows of ions, nutrients and other molecules across the cell membranes, and their activities.

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Section: Introductionmentioning

confidence: 91%

Computational Model for Membrane Transporters. Potential Implications for Cancer

Carusela

Rubı́

2021

Front. Cell Dev. Biol.

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“…These amino acids serve as substrates in several biochemical and metabolic pathways in cancer cells. Previous studies have reported that the EAATs-mediated therapeutic resistance is related to altered tumor metabolic profiles (Ye et al, 1999;de Groot et al, 2005;Tao et al, 2011;Pedraz-Cuesta et al, 2015;Sun et al, 2019;Xu et al, 2020;Guo et al, 2021). It was found that the level of glutamate and aspartate increased in the radioresistant NPC cells compared to their parental cells (Figure 5A).…”

Section: Slc1a6 Up-regulated Glutamate Level and Drug Resistance Genesmentioning

confidence: 81%

“…Although the role of SLC1A6 in cancers was not well documented, other members of the SLC1A family were reported to be overexpressed in multiple tumors and predict poor prognosis. For example, expression of SLC1A1, SLC1A2 or SLC1A3 contributed to promoting tumor progression in solid tumors, such as lung cancer, glioma, and gastric cancer (Ye et al, 1999;de Groot et al, 2005;Tao et al, 2011;Xu et al, 2020;Guo et al, 2021). Besides, the SLC1A members were also reported to be associated with drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Radioresistant Nasopharyngeal Carcinoma Cells Exhibited Decreased Cisplatin Sensitivity by Inducing SLC1A6 Expression

Hao

Cao

et al. 2021

Front. Pharmacol.

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Cisplatin-based regimens are commonly used for the treatment of nasopharyngeal carcinoma (NPC) in patients who receive concurrent chemoradiotherapy. The sensitivity of NPC cells to cisplatin is closely associated with the efficacy of radiation therapy. In this study, we established two radioresistant NPC cell lines, HONE1-IR and CNE2-IR, and found that both cell lines showed reduced sensitivity to cisplatin. RNA-sequence analysis showed that SLC1A6 was upregulated in both HONE1-IR and CNE2-IR cell lines. Downregulation of SLC1A6 enhanced cisplatin sensitivity in these two radioresistant NPC cell lines. It was also found that the expression of SLC1A6 was induced during radiation treatment and correlated with poor prognosis of NPC patients. Notably, we observed that upregulation of SLC1A6 led to elevating level of glutamate and the expression of drug-resistant genes, resulted in reduced cisplatin sensitivity. Our findings provide a rationale for developing a novel therapeutic target for NPC patients with cisplatin resistance.

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“…The PI3K/AKT signaling pathway serves an important role in regulating cell proliferation, migration and invasion ( 16 – 18 ). Therefore, in the present study, the western blotting assay was performed to determine whether circRNA_100395 function as a tumor inhibitor via regulating this signaling pathway.…”

Section: Resultsmentioning

confidence: 99%

Upregulation of circRNA_100395 sponges miR‑142‑3p to inhibit gastric cancer progression by targeting the PI3K/AKT axis

et al. 2021

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Gastric cancer (GC) has a high morbidity and mortality, hence it is very important to elucidate the molecular pathogenesis mechanism of GC progression in order to find new treatment strategies. The present study aimed to explore the biological function of circular RNA_100395 (circRNA_100395) in GC. The expression level of circRNA_100395 in GC tissues, as well as normal epithelial cells and various gastric cancer cell lines, was detected using reverse transcription-quantitative PCR. Cell Counting Kit-8, EdU assay, flow cytometry and Transwell assays were performed to investigate cell proliferation, apoptosis, migration and invasion, respectively. A dual-luciferase reporter assay was performed to detect the correlation between circRNA_100395 and micro (mi)RNA-142-3p. Western blotting was performed to elucidate the potential regulatory mechanism. circRNA_100395 expression was found to be increased in GC tissues and cell lines. However, miR-142-3p expression was significantly reduced. Besides, low expression levels of circRNA_100395 were associated with poor tumor differentiation, advanced Tumor-Node-Metastasis stage, lymph node metastasis and shorter overall survival time. Moreover, overexpression of circRNA_100395 suppressed cell proliferation, increased the apoptosis rate and suppressed cell invasion and migration by inhibiting the PI3K/AKT signaling pathway. These findings also showed that miRNA-142-3p rescued the antitumor effects induced by circRNA_100395-overexpression. cirRNA_100395-overexpression had antitumor effects via regulating the miR-142-3p signaling pathway, which might be a promising treatment target for GC.

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RETRACTED: SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway

Cited by 52 publications

References 56 publications

Computational Model for Membrane Transporters. Potential Implications for Cancer

Computational Model for Membrane Transporters. Potential Implications for Cancer

Radioresistant Nasopharyngeal Carcinoma Cells Exhibited Decreased Cisplatin Sensitivity by Inducing SLC1A6 Expression

Upregulation of circRNA_100395 sponges miR‑142‑3p to inhibit gastric cancer progression by targeting the PI3K/AKT axis

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