SLC11A1 (rs3731865) polymorphism and susceptibility to visceral leishmaniasis in HIV-coinfected patients from Northeastern Brazil

Júnior, Walter Lins Barbosa; Justo, Alda Maria; Santos, Ana Maria Aguiar; Carmo, Rodrigo Feliciano do; Melo, Fábio Lopes de; Vasconcelos, Luydson Richardson Silva; Medeiros, Zulma

doi:10.1007/s00436-019-06596-0

Cited by 5 publications

(1 citation statement)

References 34 publications

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“…Barbosa Junior et al. (2020) reported that such a variation increased the susceptibility to visceral leishmaniasis in human immunodeficiency virus‐coinfected patients in a north‐eastern Brazilian population. Additionally, Rye et al.…”

Section: Discussionmentioning

confidence: 99%

Solute carrier family 11 member 1 genetic polymorphisms rs17235409 and rs3731865 associate with susceptibility to extremity post‐traumatic osteomyelitis in a Chinese Han population

Jiang

Zhong

Lin

et al. 2023

Int J Immunogenetics

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Genetic variations in the solute carrier family 11 member 1 (SLC11A1) gene have been implicated in developing inflammatory disorders. However, it is still unclear whether such polymorphisms contribute to the pathogenesis of post‐traumatic osteomyelitis (PTOM). Therefore, this study investigated the roles of genetic variations of the SLC11A1 gene (rs17235409 and rs3731865) in PTOM development in a Chinese Han cohort. The SNaPshot method was used for genotyping 704 participants (336 patients and 368 controls) for rs17235409 and rs3731865. Outcomes revealed that rs17235409 increased the risk of PTOM occurrence by dominant (p = .037, odds ratio [OR] = 1.44) and heterozygous models (p = .035, OR = 1.45), implying AG genotype as a risk factor for PTOM development. In addition, patients with AG genotype had relatively higher levels of inflammatory biomarkers than those with AA and GG genotypes, especially for the white blood cell count and C‐reactive protein. Despite no statistically significant differences achieved, rs3731865 may reduce the PTOM susceptibility, suggested by the results of dominant (p = .051, OR = 0.67) and heterozygous (p = .068, OR = 0.69) models. In short, rs17235409 confers an elevated chance of developing PTOM, with AG genotype as a risk factor. Whether rs3731865 involves in the pathogenesis of PTOM requires further investigations.

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Section: Discussionmentioning

confidence: 99%

Solute carrier family 11 member 1 genetic polymorphisms rs17235409 and rs3731865 associate with susceptibility to extremity post‐traumatic osteomyelitis in a Chinese Han population

Jiang

Zhong

Lin

et al. 2023

Int J Immunogenetics

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Prevalence of visceral leishmaniasis among people with HIV: a systematic review and meta-analysis

Καντζάνου

Karalexi

Theodoridou

et al. 2022

Eur J Clin Microbiol Infect Dis

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Leishmaniasis is a parasitic infection expressing different clinical phenotypes. Visceral leishmaniasis (VL) is considered an opportunistic infection among people with human immunodeficiency virus (HIV). The objective of this review was to identify published data on the prevalence of Leishmania spp. infection among PWH and to define particular determinants that affect critically the epidemiological characteristics of VL-HIV coinfection and, potentially, its burden on public health. Two independent reviewers conducted a systematic literature search until June 30, 2022. Meta-analyses were conducted using random-effects models to calculate the summary prevalence and respective 95% confidence intervals (CI) of leishmaniasis among PWH. Meta-regression analysis was performed to investigate the impact of putative effect modifiers, such as the mean CD4 cell count, on the major findings. Thirty-four studies were eligible, yielding a summary prevalence of 6% (95%CI, 4–11%) for leishmaniasis (n = 1583) among PWH (n = 85,076). Higher prevalence rates were noted in Asia (17%, 95%CI, 9–30%) and America (9%, 95%CI, 5–17%) than in Europe (4%, 95%CI, 2–8%). Prevalence rates were significantly mediated by the age, sex, and CD4 cell count of participants. Heterogeneity remained significant in all meta-analyses (p < 0.0001). In the majority of included studies, people were coinfected with HIV and Leishmania species associated with VL, as opposed to those associated with cutaneous leishmaniasis. No sign of publication bias was shown (p = 0.06). Our summary of published studies on leishmaniasis among PWH is important to provide prevalence estimates and define potential underlying factors that could guide researchers to generate and further explore specific etiologic hypotheses.

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Unwelcome prevalence of leishmaniasis with several other infectious diseases

Saini

Joshi²,

Kaur

2022

International Immunopharmacology

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SLC11A1 (rs3731865) polymorphism and susceptibility to visceral leishmaniasis in HIV-coinfected patients from Northeastern Brazil

Cited by 5 publications

References 34 publications

Solute carrier family 11 member 1 genetic polymorphisms rs17235409 and rs3731865 associate with susceptibility to extremity post‐traumatic osteomyelitis in a Chinese Han population

Solute carrier family 11 member 1 genetic polymorphisms rs17235409 and rs3731865 associate with susceptibility to extremity post‐traumatic osteomyelitis in a Chinese Han population

Prevalence of visceral leishmaniasis among people with HIV: a systematic review and meta-analysis

Unwelcome prevalence of leishmaniasis with several other infectious diseases

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