Abstract:CBL is a RING type E3 ubiquitin ligase that functions as a negative regulator of tyrosine kinase signaling and loss of CBL function is implicated in several forms of leukemia. The Srclike adaptor proteins (SLAP/SLAP2) bind to CBL and are key components of CBL-dependent downregulation of antigen receptor, cytokine receptor, and receptor tyrosine kinase signaling. To understand the molecular basis of the interaction between SLAP/SLAP2 and CBL, we solved the crystal structure of CBL tyrosine kinase binding domain… Show more
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