SLAMF receptors and disease

doi:10.1016/j.clim.2019.07.008

Cited by 3 publications

(2 citation statements)

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“…The engagement of SLAMF triggers the phosphorylation of immunoreceptor tyrosine motif switch motifs which are docking sites that link these receptors to intracellular adaptor molecules such as SLAMassociated protein and Ewing's Sarcoma transcript-2 or Src homology 2-carrying enzymes. 32 As a member of the SLAMF family, studies have shown that SLAMF8 participates in acute kidney transplant rejection, liver inflammation, tumors, and other diseases. [33][34][35][36] In RA, SLAMF8 participates in the progression of RA through the Toll-like receptor 4/nuclear factor kappa B signaling pathway, 37 and moreover, it can promote the proliferation and migration of FLSs by regulating the extracellular regulated protein kinases (ERK)/matrix metalloproteinases (MMPs) signaling pathway, thereby aggravating RA.…”

Section: Discussionmentioning

confidence: 99%

SLAMF8 as a potential biomarker for rheumatoid arthritis identified by comparing peripheral blood mononuclear cells, fibroblast‐like synoviocytes, and synovial tissue using bioinformatics analysis

Zhang,

Huang,

Zhang

et al. 2024

Rheumatology & Autoimmunity

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BackgroundRheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. Its pathogenesis is not fully understood, and early diagnosis is challenging owing to the lack of effective biomarkers. This study aimed to analyze different samples to identify potential biomarkers and therapeutic targets.MethodsMicroarray datasets of RA, osteoarthritis (OA), and healthy control (HC) were downloaded from the Gene Expression Omnibus database. R software was used to identify differentially expressed genes (DEGs), which were visualized using volcano and heat maps. Venn diagrams, principal component analysis, gene set enrichment analysis, gene ontology, and Kyoto Encyclopedia of genes and genomes were used to analyze the data. A protein–protein interaction network was constructed, and synovial tissues from patients with RA and OA were collected for verification using the collagen‐induced arthritis mouse model.ResultsMore DEGs were found in synovial tissues than in peripheral blood mononuclear cells or fibroblast‐like synoviocytes. Principal component analysis revealed significant differences between the RA and OA samples, highlighting the unique advantages of synovial tissue. Enrichment analysis revealed that metabolic and cytokine signaling pathways play crucial roles in the development of RA. Further analysis of the four synovial datasets identified 54 DEGs, of which signaling lymphocytic activation molecule family (SLAMF) 8 was identified as the key molecule. SLAMF8 levels were increased in the synovial tissue of patients with RA compared to those of patients with OA (0.38 ± 0.19 vs. 12.40 ± 1.66), and SLAMF8 levels were similarly elevated in collagen‐induced arthritis model mice compared with those in the healthy mice (1.13 ± 0.47 vs. 9.05 ± 2.5).ConclusionsThis study established the unique advantages of synovial tissue for RA research and identified metabolic and cytokine signaling pathways as important for RA development. Thus, SLAMF8 may be a potential therapeutic target for RA.

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Section: Discussionmentioning

confidence: 99%

SLAMF8 as a potential biomarker for rheumatoid arthritis identified by comparing peripheral blood mononuclear cells, fibroblast‐like synoviocytes, and synovial tissue using bioinformatics analysis

Zhang,

Huang,

Zhang

et al. 2024

Rheumatology & Autoimmunity

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“…Emerging evidence indicates that SLAMFs play multifunctional roles in tumorigenesis and progression [12][13][14]. For example, SLAMF1 has been found to promote hematologic tumor cell survival and proliferation [15], and induce methotrexate resistance in choriocarcinoma cells [16].…”

Section: Introductionmentioning

confidence: 99%

SLAMF7 predicts prognosis and correlates with immune infiltration in serous ovarian carcinoma

Deng

Zhang

Dai

et al. 2023

Preprint

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Background: Signaling lymphocytic activation molecule family members (SLAMFs) play a critical role in immune regulation of malignancies. However, the function of SLAMFs in ovarian cancer (OV) is rarely studied. Methods: The expression analysis of SLAMFs was conducted based on the TCGA-OV and GEO databases. Immunohistochemistry (IHC) was further performed on tissue arrays (n = 98) to determine the expression of SLAMF7. Kaplan-Meier plotter and multivariate Cox regression model were used to evaluate the correlation of SLAMF7 expression with survival outcomes of patients. The molecular function of SLAMF7 in OV was further investigated using Gene Set Enrichment Analysis (GSEA). Results: SLAMF7 mRNA expression were significantly upregulated in OV tumor tissue compared to normal tissue. IHC revealed that SLAMF7 expression was located in the interstitial parts of tumor tissue, and higher SLAMF7 expression was associated with favorable survival outcomes. GSEA demonstrated that SLAMF7 is involved immune-related pathways. Further analysis showed that SLAMF7 had a strong correlation with the T cell-specific biomarker (CD3) but not with the B cell (CD19, CD22, and CD23) and NK cell-specific biomarkers (CD85C, CD336, and CD337). Furthermore, IHC analysis confirmed that SLAMF7 was expressed intumor-infiltrating T cells, and the IHC score of SLAMF7 was positively correlated with CD3 (r = 0.846, P＜0.001). Conclusions: SLAMF7 is expressed in the interstitial components of clinical OV tissue, and higher SLAMF7 expression indicated a favorable prognosis for patients with OV. Additionally, SLAMF7 is involved in T-cell immune infiltration in OV.

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SLAMF7 predicts prognosis and correlates with immune infiltration in serous ovarian carcinoma

Deng,

Zhang,

Dai

et al. 2024

J Gynecol Oncol

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SLAMF receptors and disease

Cited by 3 publications

References 7 publications

SLAMF8 as a potential biomarker for rheumatoid arthritis identified by comparing peripheral blood mononuclear cells, fibroblast‐like synoviocytes, and synovial tissue using bioinformatics analysis

SLAMF8 as a potential biomarker for rheumatoid arthritis identified by comparing peripheral blood mononuclear cells, fibroblast‐like synoviocytes, and synovial tissue using bioinformatics analysis

SLAMF7 predicts prognosis and correlates with immune infiltration in serous ovarian carcinoma

SLAMF7 predicts prognosis and correlates with immune infiltration in serous ovarian carcinoma

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