SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer

Tojjari, Alireza; Giles, Francis J.; Vilbert, Maysa; Saeed, Anwaar; Cavalcante, Ludimila

doi:10.3390/cancers15194808

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…CD150 is a self-ligand considered to have a notable role in adhesion and in signaling in the immune synapse between T cells and antigen-presenting cells ( 30 ). Moreover, CD150 may be involved in cancer malignancy and autoimmune disorders, including inflammatory bowel syndrome, rheumatoid arthritis, multiple sclerosis, hepatitis, systemic lupus erythematosus and XLP ( 3 - 5 , 31 ). The results of the present study demonstrated that CD150 was gradually expressed on the B cell surface during EBV infection and was fully expressed on the surface after 4 weeks of EBV exposure.…”

Section: Discussionmentioning

confidence: 99%

CD150‑dependent activation of EBV‑transformed B cells induces the differentiation of peripheral blood monocytes via the secretion of multiple cytokines

Kim,

Seo,

Hur

2024

Int J Mol Med

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CD150, also termed signaling lymphocyte activation molecule family member 1, is a cell surface receptor expressed on T cells, B cells, dendritic cells (DCs) and some tumors. Stimulation of CD150 on immune cells induces cell proliferation and cytokine production. However, the function of CD150 in Epstein-Barr virus (EBV)-infected B cells is still not fully understood. In the present study, CD150 expression on B cells increased rapidly following EBV infection, and various CD150 antibodies, measles viral proteins and recombinant CD150 proteins induced the secretion of multiple cytokines in both CD150 + EBV-transformed B cells and EBV + lymphoma cells. Notably, the IL-1α protein level showed the greatest increase among all cytokines measured. The culture supernatant containing these cytokines induced the rapid differentiation of monocytes to DCs after only 2 days in vitro , which was faster than the established DC maturation time. Furthermore, knockdown of CD150 expression led to a reduction in the secretion of multiple cytokines, and monocyte differentiation was partially inhibited by anti-IL-1α and anti-granulocyte-macrophage colony-stimulating factor neutralizing antibodies. Collectively, the results of the present study suggest that CD150 activation triggers cytokine production in EBV-transformed B cells, and that measles virus coinfection might affect immune responses through the production of various cytokines in EBV + lymphoma cells.

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Section: Discussionmentioning

confidence: 99%

CD150‑dependent activation of EBV‑transformed B cells induces the differentiation of peripheral blood monocytes via the secretion of multiple cytokines

Kim,

Seo,

Hur

2024

Int J Mol Med

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From mechanism to therapy: the journey of CD24 in cancer

Zhao,

Wu,

et al. 2024

Front. Immunol.

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CD24 is a glycosylphosphatidylinositol-anchored protein that is expressed in a wide range of tissues and cell types. It is involved in a variety of physiological and pathological processes, including cell adhesion, migration, differentiation, and apoptosis. Additionally, CD24 has been studied extensively in the context of cancer, where it has been found to play a role in tumor growth, invasion, and metastasis. In recent years, there has been growing interest in CD24 as a potential therapeutic target for cancer treatment. This review summarizes the current knowledge of CD24, including its structure, function, and its role in cancer. Finally, we provide insights into potential clinical application of CD24 and discuss possible approaches for the development of targeted cancer therapies.

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Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma

Song,

Wang,

Shi

et al. 2024

Oncol Lett

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Clear cell renal cell carcinoma (ccRCC) is a common type of kidney cancer and accounts for 2-3% of all cancer cases. Furthermore, a growing number of immunotherapy approaches are being used in antitumor treatment. Signaling lymphocyte activation molecule family (SLAMF) members have been well studied in several cancers, whereas their roles in ccRCC have not been investigated. The present study comprehensively assessed the molecular mechanisms of SLAMF members in ccRCC, performed using The Cancer Genome Atlas database, with analysis of gene transcription, prognosis, biological function, clinical features, tumor-associated immune cells and the correlation with programmed cell death protein 1/programmed death-ligand 1 immune checkpoints. Simultaneously, the Tumor Immune Dysfunction and Exclusion algorithm was used to predict the efficacy of immune checkpoint blockade (ICB) therapy in patients with high and low SLAMF expression levels. The results demonstrated that all SLAMF members were highly expressed in ccRCC, and patients with high expression levels of SLAMF1, 4, 7 and 8 had a worse prognosis that those with low expression. SLAMF members were not only highly associated with immune activation but also with immunosuppressive agents. The level of immune cell infiltration was associated with the prognosis of patients with ccRCC with high SLAMF expression. Moreover, high ICB response rates were observed in patients with high expression levels of SMALF1 and 4. In summary, SLAMF members may serve as future potential biomarkers for predicting the prognosis of ccRCC and emerge as a novel immunotherapy target.

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SLAM Modification as an Immune-Modulatory Therapeutic Approach in Cancer

Cited by 3 publications

References 65 publications

CD150‑dependent activation of EBV‑transformed B cells induces the differentiation of peripheral blood monocytes via the secretion of multiple cytokines

CD150‑dependent activation of EBV‑transformed B cells induces the differentiation of peripheral blood monocytes via the secretion of multiple cytokines

From mechanism to therapy: the journey of CD24 in cancer

Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma

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