Slab Waveguides in Chemistry

Lee, Kang; Dessy, Raymond E.

doi:10.1080/10408349008051634

Cited by 11 publications

(12 citation statements)

References 63 publications

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“…Some of the research groups that are actively involved in studying protein adsorption on surfaces based on ITR are Jeremy Ramsden's group in Basel, Switzerland, 28-37 Scott Saavedra's group in Arizona, [18][19][20][21][22][23][24][25][26][27] Paul R. Van Tassel's group in Wayne, USA 38,40 and some research groups in Japan [4][5][6][7][8][9][10][11][12][13][14][15][16][17]39 and elsewhere. 41,42 In this work we investigated, under various solution conditions, the adsorption behavior of hemoglobin, myoglobin and cytochrome c in a bare quartz surface. The quartz used in this investigation was utilized as a waveguide in SOWG spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

Adsorption Behavior of Cytochrome c, Myoglobin and Hemoglobin in a Quartz Surface Probed Using Slab Optical Waveguide (SOWG) Spectroscopy

Santos

Matsuda

et al. 2003

ANAL. SCI.

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Slab optical waveguide (SOWG) spectroscopy was used to observe the adsorption behavior of three important heme proteins, namely cytochrome c, myoglobin and hemoglobin, in a quartz surface. Using prism-coupled polychromatic visible light propagated into a quartz waveguide by internal total reflection, the real-time monitoring of evanescent wave absorption revealed a strong dependence of the protein-surface interaction on the protein concentration, the solution pH and the ionic strength. For the three proteins studied, the absorbance-bulk concentration ratio was higher at low bulk concentrations, and decreased at higher concentrations. For cytochrome c and myoglobin, the absorbance approached a limiting value, but buffered hemoglobin surprisingly did not show any indication of forming a signal plateau. Moreover, the slow introduction of protein into the solution lessened the total adsorbed amount per unit area. These observations suggested a possible conformational transition of the protein molecules at the quartz surface after adsorption. For a bulkier protein, hemoglobin, adsorption onto the quartz surface was enhanced in the presence of a phosphate buffer, while the opposite effect was observed for the smaller cytochrome c and myoglobin molecules. The results of pH studies concurred with the electrostatic interactions predicted from the isoelectric data of proteins and the quartz surface.

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Section: Introductionmentioning

confidence: 99%

Adsorption Behavior of Cytochrome c, Myoglobin and Hemoglobin in a Quartz Surface Probed Using Slab Optical Waveguide (SOWG) Spectroscopy

Santos

Matsuda

et al. 2003

ANAL. SCI.

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“…4, the sensor absorbance contains two terms. The rst term essentially follows Beer's law but is also dependent on the refractive index of the cladding since h has a 1/V dependence, 3 where V 5 (2pr /l) •(n 1 2 2 n 2 2 ) 1/2 is a dimensionless number that indicates how m any modes (allowed propagation paths) 41 a ber can support. 42 The second term represents a light-guiding relationship dependent on the refractive indices of the core and cladding.…”

Section: Resultsmentioning

confidence: 99%

Fiber-Optic Evanescent-Wave Absorption Copper(II) Sensor Based on Sol-Gel-Derived Organofunctionalized Silica Cladding

2001

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A fiber-optic evanescent-wave absorption sensor was constructed on the basis of an organofunctionalized silica cladding. The cladding material was prepared by the sol-gel processing of an organofunctional silicon alkoxide, which contains a propyl-ethylenediamine triacetate (PEDTA) group. The PEDTA group can chelate with a Cu(II) ion to form a colored complex. Because of the large formation constant of the complexation reaction, a kinetic approach was used to quantify the Cu(II) content in samples. The sensor has a dynamic range of 0.5–100 ppm and a detection limit of 56 ppb. The measurement of the Cu(II) content in a scattering medium has also been demonstrated.

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“…A dielectric waveguide (WG) structure, supporting confined modes, leads to field enhancement at the positions of adsorbed molecules, and thus to SERS, as well. Slab WGs can lead to enhancements of about 3 orders of magnitude [17][18][19][20], and have been used to study Raman scattering from thin polymer films [21], monolayers of proteins [22], and bacteriorhodopsin [23]. Coupled WGs have also been used to study the Raman scattering from a thin liquid film between them [24].…”

Section: Introductionmentioning

confidence: 99%

Surface enhanced Raman scattering in the presence of multilayer dielectric structures

2012

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We perform a systematic study of spontaneous Raman scattering in resonant planar structures. We present a semiclassical approach that allows the description of spontaneous Raman scattering in an arbitrary multilayer, providing analytical expressions of the Raman cross sections in terms of the Fresnel coefficients of the structure and taking into account beam size effects. Large enhancements of the Raman cross section are predicted in fully dielectric structures. In particular, given our results, truncated periodic multilayers supporting Bloch surface waves might be of interest for the realization of integrated Raman sensor devices.

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Slab Waveguides in Chemistry

Cited by 11 publications

References 63 publications

Adsorption Behavior of Cytochrome c, Myoglobin and Hemoglobin in a Quartz Surface Probed Using Slab Optical Waveguide (SOWG) Spectroscopy

Adsorption Behavior of Cytochrome c, Myoglobin and Hemoglobin in a Quartz Surface Probed Using Slab Optical Waveguide (SOWG) Spectroscopy

Fiber-Optic Evanescent-Wave Absorption Copper(II) Sensor Based on Sol-Gel-Derived Organofunctionalized Silica Cladding

Surface enhanced Raman scattering in the presence of multilayer dielectric structures

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