Skullcaps (Scutellaria spp.): Ethnobotany and Current Research

Irvin, Lani; Jackson, Carissa L.; Hill, Aisha L.; Bajaj, Richa; Mahmoudi, Chonour; Vaidya, Brajesh Nanda; Joshee, Nirmal

doi:10.1007/978-3-030-31269-5_7

Cited by 13 publications

(8 citation statements)

References 102 publications

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“…The genus Scutellaria (family Lamiaceae), is used in traditional medical systems throughout Asia, Europe and North American countries (Paton, 1990;Cole et al, 2008;Shang et al, 2010;Joshee et al, 2012;Irvin et al, 2019). Scutellaria alpina L., (Alpine skullcap) grows in central and southern Europe and Russia and Scutellaria altissima L. (Somerset skullcap; tall skullcap) is a perennial herb from the mountainous regions of South Europe, East Asia and South America (Grzegorczyk-Karolak;Wysokińska, 2013).…”

Section: Introductionmentioning

confidence: 99%

In vitro propagation and synseed mediated short-term conservation of Scutellaria alpina L. and Scutellaria altissima L.

Zakaria¹,

Sherman

Vaidya

et al. 2020

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Section: Introductionmentioning

confidence: 99%

In vitro propagation and synseed mediated short-term conservation of Scutellaria alpina L. and Scutellaria altissima L.

Zakaria¹,

Sherman

Vaidya

et al. 2020

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“…Pharmacological studies have confirmed that total extracts or isolated flavonoids from Scutellaria species possess anti-lipoperoxidation, anti-platelet, anti-inflammatory [ 3 ], antitumor [ 4 , 5 , 6 ], anticancer [ 7 ], neuroprotective [ 8 ] antithrombotic, antioxidant [ 9 , 10 ], hepatoprotective, antibacterial [ 11 ], and antiviral [ 2 ] activities. A recent review details ethnobotanical knowledge surrounding various Scutellaria species from different parts of the world and current ongoing biomedical studies [ 12 ]. Extracts from various parts of Scutellaria species possess antitumor, hepatoprotective, antioxidant, antibacterial, and antiviral effects [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Micropropagation of Rare Scutellaria havanensis Jacq. and Preliminary Studies on Antioxidant Capacity and Anti-Cancer Potential

et al. 2021

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We report the development of in vitro propagation protocols through an adventitious shoot induction pathway for a rare and medicinal Scutellaria havanensis. In vitro propagation studies using nodal explants showed MS medium supplemented with 10 µM 6-Benzylaminopurine induced the highest number of adventitious shoots in a time-dependent manner. A ten-day incubation was optimum for shoot bud induction as longer exposures resulted in hyperhydricity of the explants and shoots induced. We also report preliminary evidence of Agrobacterium tumefaciens EHA105-mediated gene transfer transiently expressing the green fluorescent protein in this species. Transformation studies exhibited amenability of various explant tissues, internode being the most receptive. As the plant has medicinal value, research was carried out to evaluate its potential antioxidant capacity and the efficacy of methanolic leaf extracts in curbing the viability of human colorectal cancer cell line HCT116. Comparative total polyphenol and flavonoid content measurement of fresh and air-dried leaf extract revealed that the fresh leaf extracts contain higher total polyphenol and flavonoid content. The HCT 116 cell viability was assessed by colorimetric assay using a 3-(4,5-dimethyl-thiazol-2-yl)-2, 5-diphenyltetrazolium bromide, showed a steady growth inhibition after 24 h of incubation. Scanning electron microscopy of leaf surface revealed a high density of glandular and non-glandular trichomes. This research provides a basis for the conservation of this rare plant and future phytochemical screening and clinical research.

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“…Other uses are described for Scutellaria spp. coming from many other regions of the world (Kokakowska 2017; Irvin et al 2019).…”

Section: Introductionmentioning

confidence: 99%

A novel study approach on Scutellaria altissima L. cultivated at the Ghirardi Botanic Garden (Lombardy, Italy)

et al. 2020

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Within an Open Science project, research was carried out to describe to the public of the Ghirardi Botanic Garden (BS, Lombardy, Italy) the invisible features of plants. This work is dedicated to Scutellaria altissima L. (Lamiaceae). Micromorphological, histochemical and phytochemical investigations were conducted on the vegetative and reproductive organs to correlate the structures involved in the emission of substances and their unique productivity. This work reports volatile organic compound (VOC) profiles of leaves and flowers and the composition of essential oil (EO) obtained from aerial parts of plants cultivated in Italy that have never been described before. Three morphotypes of glandular trichomes were observed: peltate, short‐stalked capitate and long‐stalked capitate. Peltate trichomes were the main producers of terpenes, short‐stalked capitates of polysaccharides and long‐stalked capitates of terpenes and polyphenols. The leaf VOC profile showed heterogeneous composition, with non‐terpene derivatives as the major chemical class (71.04%), while monoterpene hydrocarbons represented almost the totality of the flower (99.73%). The leaf presented a higher number of total (37 versus 11) and exclusive (33 versus 7) compounds. (Z)‐3‐Hexenol acetate was most abundant in the leaf and (E)‐β‐ocimene in the flower. Four common compounds were detected: β‐pinene, β‐caryophyllene, γ‐muurolene and germacrene‐D. The EO contaied 21 compounds, dominated by β‐caryophyllene, linalool and hexahydrofarnesyl acetone. This research allowed us to correlate morphotypes of the secretory structures with the production of secondary metabolites, with the aim of providing the public of the Ghirardi Botanic Garden with a dedicated iconographic approach, which accounts for olfactory perception linked to S. altissima.

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Skullcaps (Scutellaria spp.): Ethnobotany and Current Research

Cited by 13 publications

References 102 publications

In vitro propagation and synseed mediated short-term conservation of Scutellaria alpina L. and Scutellaria altissima L.

In vitro propagation and synseed mediated short-term conservation of Scutellaria alpina L. and Scutellaria altissima L.

Micropropagation of Rare Scutellaria havanensis Jacq. and Preliminary Studies on Antioxidant Capacity and Anti-Cancer Potential

A novel study approach on Scutellaria altissima L. cultivated at the Ghirardi Botanic Garden (Lombardy, Italy)

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