Skull Density Ratio as Arm‐Allocation Parameter for a Controlled Focused Ultrasound Trial in Parkinson's Disease
José Angel Pineda‐Pardo,
Raul Martínez‐Fernández,
Elena Natera‐Villalba
et al.
Abstract:BackgroundMR‐guided focused ultrasound (FUS) thermoablation is an established therapy for movement disorders. FUS candidates must meet a predefined threshold of skull density ratio (SDR), a parameter that accounts for the efficiency in reaching ablative temperatures. Randomized sham‐controlled trials to provide definitive therapeutic evidence employ pure randomization of subjects into active treatment or control arms. The latter design has several general limitations.ObjectiveTo demonstrate that SDR values are… Show more
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