Skull bone metastasis with adjacent leptomeningeal involvement from pleomorphic lobular carcinoma of the breast

Chen, Linying; Ni, Yun‐Bi; Lacambra, Maribel D.; Lee, Wilson C K; Ho, Kenneth K F; Tse, Gary M.

doi:10.1111/his.12576

Cited by 9 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Invasive lobular carcinoma has a propensity for leptomeninges, and in one case of pleomorphic lobular carcinoma, the tumor initially presented as a skull bone mass, with direct extension to the dura and leptomeninges. 6 It has been reported that pleomorphic lobular carcinoma behaves more aggressively than classic lobular carcinoma with a propensity for early metastases. 5 Although e-cadherin positivity is usually a feature almost exclusively of ductal carcinoma, it has been reported to be positive in lobular carcinoma and the morphology and patient history supported a diagnosis of pleomorphic lobular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Pleomorphic Lobular Carcinoma of the Breast to the Hypothalamus Presenting as a Primary Pituitary Lesion Presenting 17 Years Later-Report of a Case and Review of the Literature

et al. 2022

View full text Add to dashboard Cite

Carcinomas metastatic to the brain are common, however, metastatic disease to the hypothalamic- pituitary region is uncommon and account for less than 3.6% of all resected malignant pituitary tumors. Most metastatic disease in that region derives from a lung or breast primary, with both ductal and lobular carcinoma reported. We report what we believe is the first case of pleomorphic lobular carcinoma metastatic to the hypothalamus. This case is also reaffirms that late metastasis from breast cancer should be considered in the differential diagnosis. It is important for the clinician to consider the clinical history of breast cancer, even when remote, in the differential diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Metastatic Pleomorphic Lobular Carcinoma of the Breast to the Hypothalamus Presenting as a Primary Pituitary Lesion Presenting 17 Years Later-Report of a Case and Review of the Literature

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Resim 2-3: Postkontrast aksiyel ve koronal kesitlerde T1 MRG'de sağ kavernöz sinüste belirgin kontrastlanan leptomeningeal metastatik kitle lezyon (oklar). t diğer malignitelere sekonder LK ile karşılaştırıldığında en iyi prognoza sahip olmasına rağmen agresif olan bazı hastalarda 4 aya kadar uzayan sağ kalım süresi ile hala kötü prognozludur (5,6). LK de sık görülen belirti ve bulgular; baş ağrısı, radiküler ağrı, kranial sinir felçleri, görme bozuklukları, işitme kaybı, nöbetler ve kauda ekuina sendromudur.…”

Section: Discussionunclassified

Üçüncü Kranial Sinir Paralizisi ile Gelen Leptomeningeal Metastaz Olgusu

Şimşek

Aktaş

Eren

et al. 2020

SDÜ Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Leptomeningeal karsinomatozis nadir görülen nörolojik bir komplikasyondur. Sistemik tümörlerin birçoğunda beyin metastazı görülmesine rağmen leptomeningeal metastaz görülmesi nadirdir. Meme kanserli hastalarda leptomeningeal tutulum oranı düşük olmakla birlikte en sık leptomeningeal metastaza neden olan tümör meme kanseridir. Tanı anında hastaların sistemik hastalıkları çoğunlukla ileri evrededir. Tanı için BOS histopatolojik incelemesi ve dikkatli bir şekilde kontrastlı beyin görüntülemelerinin değerlendirilmesi önemlidir. Bu hastalarda beyin görüntülemelerinin tamamen normal olabilmesi ihtimalinden dolayı BOS incelemesi ayrı bir öneme sahiptir. Leptomeningeal metastaz gelişen hastalarda yaşam süresi kısa olup, hastalara çoğunlukla palyatif tedavi önerilir. Palyatif tedaviye erken başlanması hastaların yaşam standartlarının daha uzun süre, daha iyi seyretmesini sağlayabildiği için leptomeningeal metastazda da erken tanı önemlidir. Bu yazıda, meme kanseri olan ve üçüncü kranial sinir paralizisi ile nöroloji kliniğinde takip edilen leptomeningeal metastazlı bir olguyu nadir görülen klinik bir tablo olması nedeni ile sunduk.

show abstract

“…Metastases of the petrous temporal bone must also be distinguished from facial nerve haemangioma characterized by enlargement of the facial canal with poorly defined margins associated with small calcifications, in contrast with schwannoma, which presents heterogeneous gadolinium enhancement on T1-weighted MRI [6]. The prognosis of metastases from primary solid tumours, regardless of the histological type, is very poor and patients often die within a few months [7].…”

Section: Answermentioning

confidence: 99%

Bell's palsy

Villeneuve

Aussedat

Bakhos

2016

European Annals of Otorhinolaryngology, Head and Neck Diseases

View full text Add to dashboard Cite

Case reportA 79-year-old woman presented with sudden onset of left peripheral facial nerve (Bell's) palsy. Clinical ENT examination demonstrated features of House-Brackmann grade III left Bell's palsy. The rest of the clinical examination, particularly the neurological examination, was normal. The audiogram showed presbyacusis and absence of the left stapedial reflex. ClinicalFig. 1. a: CT scan, coronal section of the left petrous temporal bone showing an irregular low-density image (arrow), eroding the cochlea and tegmen tympani, with no calcifications, in contact with the meatal segment of the facial nerve; b: MRI, axial section, gadolinium-enhanced T1-weighted sequence showing an irregular lesion of the petrous temporal bone (arrow) with intense, homogeneous gadolinium enhancement, extending into the facial canal and middle cranial fossa. (A. Villeneuve).interview revealed a history of hormone therapy (letrozole) for bilateral breast cancer initially treated by surgery followed by radiotherapy 15 years previously, as well as antihypertensive treatment. Signs of Bell's palsy had completely resolved at the follow-up visit. Six months later, she returned with recurrence of left Bell's palsy. Computed tomography (Fig. 1a, coronal section) and magnetic resonance imaging (Fig. 1b, axial section) of petrous temporal bones were then performed. What is your diagnosis?http://dx.

show abstract

Skull bone metastasis with adjacent leptomeningeal involvement from pleomorphic lobular carcinoma of the breast

Cited by 9 publications

References 6 publications

Metastatic Pleomorphic Lobular Carcinoma of the Breast to the Hypothalamus Presenting as a Primary Pituitary Lesion Presenting 17 Years Later-Report of a Case and Review of the Literature

Metastatic Pleomorphic Lobular Carcinoma of the Breast to the Hypothalamus Presenting as a Primary Pituitary Lesion Presenting 17 Years Later-Report of a Case and Review of the Literature

Üçüncü Kranial Sinir Paralizisi ile Gelen Leptomeningeal Metastaz Olgusu

Bell's palsy

Contact Info

Product

Resources

About