Skull base surgery for pediatric parameningeal sarcomas

Deneuve, Sophie; Teissier, Natacha; Jouffroy, Thomas; Helfre, Sylvie; Boissonnet, Hervé; Fréneaux, Paul; Brisse, H.; Abbeele, Thierry Van Den; Orbach, Daniel

doi:10.1002/hed.21865

Cited by 4 publications

(4 citation statements)

References 23 publications

(31 reference statements)

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“…Of the 112 papers selected for retrieval, 85 articles failed to meet our inclusion criteria and were subsequently excluded. Thus, 27 articles were included in this systematic review based upon the prespecified criteria ( Supplementary Table S2 ) [ 1 , 2 , 3 , 6 , 7 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

Tumors Involving the Infratemporal Fossa: A Systematic Review of Clinical Characteristics and Treatment Outcomes

Bin-Alamer

Bhenderu²,

Palmisciano³

et al. 2022

Cancers

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Background: Infratemporal fossa (ITF) tumors represent various pathologies and are seldom described in the literature, reflecting their rarity. Here we review the literature on tumors invading ITF and describe patient characteristics, treatment strategies, and clinical outcomes. Methods: Relevant articles were retrieved from PubMed, Scopus, and Cochrane. A systematic review and meta-analysis were conducted on the clinical presentation, treatment protocols, and clinical outcomes. Result: A total of 27 articles containing 106 patients with ITF tumors (median tumor size: 24.3 cm3 [interquartile range, 15.2–42 cm3]) were included (median age: 46 years [interquartile range, 32–55 years]; 59.4% were males]). Of the confirmed tumor pathology data, schwannomas (n = 24; 26.1%) and meningiomas (n = 13; 14.1%) were the most common tumors. Facial hypoesthesia (n = 22; 18.5%), auricular/preauricular pain (n = 20; 16.8%), and headaches (n = 11; 9.2%) were the most common presenting symptoms. Of patients who had surgical resection (n = 97; 95.1%), 70 (73.7%) had transcranial surgery (TCS) and 25 (26.3%) had endoscopic endonasal surgery (EES). Among available details on the extent of resection (n = 84), gross-total resection (GTR) was achieved in 62 (73.8%), and 5 (6.0%) had biopsy only. Thirty-five (33.0%) patients had postoperative complications. Among cases with available data on reconstruction techniques (n = 8), four (50%) had adipofascial antero-lateral thigh flap, three (37.5%) had latissimus dorsi free flap, and one (12.5%) had antero-lateral thigh flap. Fourteen (13.2%) patients had adjuvant chemotherapy, and sixteen (15.1%) had adjuvant radiotherapy. During a median follow-up time of 28 months (IQR, 12.25–45.75 months), 15 (14.2%) patients had recurrences, and 18 (17.0%) patients died. The median overall survival (OS) time was 36 months (95% confidence interval: 29–41 months), and the 5-year progression-free survival (PFS) rate was 61%. Conclusion: Various tumor types with different biological characteristics invade the ITF. The present study describes patient demographics, clinical presentation, management, and outcomes. Depending on the tumor type and patient condition, patient-tailored management is recommended to optimize treatment outcomes.

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Section: Resultsmentioning

confidence: 99%

Tumors Involving the Infratemporal Fossa: A Systematic Review of Clinical Characteristics and Treatment Outcomes

Bin-Alamer

Bhenderu²,

Palmisciano³

et al. 2022

Cancers

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“…There is no consensus in treatment for pediatric skull base tumors; thus, they are a challenge for oncologists, pediatric surgeons, and radiation practitioners. Multidisciplinary therapy, including surgery, radiotherapy, and chemotherapy, has become a treatment modality for pediatric skull base tumors . However, children are known to be more sensitive to radiation‐induced malignancies than adults by a factor of more than 10 times, and long‐term radiotherapy‐related complications, such as facial growth disorders and dental abnormalities in pediatric patients, have been frequently reported .…”

Section: Discussionmentioning

confidence: 99%

“…Multidisciplinary therapy, including surgery, radiotherapy, and chemotherapy, has become a treatment modality for pediatric skull base tumors. 16,17,19,20 However, children are known to be more sensitive to radiation-induced malignancies than adults by a factor of more than 10 times, and long-term radiotherapy-related complications, such as facial growth disorders and dental abnormalities in pediatric patients, have been frequently reported. 21,22 Ideal dose distribution is difficult by conventional radiotherapy techniques, especially in the head and neck region.…”

Section: Discussionmentioning

confidence: 99%

¹²⁵I interstitial brachytherapy in management of pediatric skull base tumors

Chen

et al. 2019

Pediatric Blood & Cancer

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Background The purpose of this study was to present our preliminary assessment of the safety and efficacy of 125I interstitial brachytherapy (IBT) in the management of pediatric skull base tumors. Methods Thirty pediatric patients with skull base tumors treated with 125I IBT from April 2007 to May 2017 were included in this study. The probabilities of local control (LC) and overall survival (OS) were calculated by the Kaplan–Meier method. Results The one‐ and two‐year LC rates were 96.7% and 74.8%, respectively. The one‐ and two‐year OS rates were 93.3% and 72.2%, respectively. No severe acute toxicity was observed. Severe late toxicities were observed in one (3.33%) of 30 patients. Conclusion 125I IBT is effective and safe in the management of pediatric skull base tumors, with satisfactory cosmetic and functional outcomes.

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“…S. Deneuve и соавт. обосновали применение хирур-гического лечения радиоиндуцированных сарком у детей [16]. Таким образом, были сформулированы основные показания для хирургического удаления сарком у детей.…”

Section: гистологическое и молекулярное исследованиеunclassified

Clinical Significance of Transnasal Endoscopic Surgery in the Treatment of Children With Localized Parameningeal Sarcomas

et al. 2017

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ОБОСНОВАНИЕСаркомы костей и мягких тканей чаще встречают-ся у пациентов моложе 21 года. Рабдомиосаркома (РМС) -основной гистологический тип сарком дет-ского возраста, который составляет до 6% всех опу-холей у пациентов младше 15 лет. РМС чаще (36%) локализуется в органах головы и шеи. По лока-лизации саркомы головы и шеи разделяют на два анатомических региона -пара-и непараменин-геальный, различающиеся прогнозом заболева-ния. К параменингеальной локализации относятся опухоли, расположенные в полости носа, носоглот-ке, околоносовых пазухах, среднем ухе, височной кости, а также в подвисочной и крылонебной ямках [1]. Другие морфологические варианты сарком мягких тканей параменингеальной локализации и саркомы костей основания черепа составляют не более 1% среди всех злокачественных опухолей детского возраста. Лечебные подходы основаны на проведении полихимиотерапии (ПХТ) в предоперационном периоде и лучевой терапии при чувствительности опухоли к лучевому воздействию.Результаты международных исследовательских групп IRS 1 и COG 2 убедительно доказали влияние на исход лечения детей с РМС таких независимых факторов, как локализация первичной опухоли, размер, инвазия в соседние органы и ткани, а так-же метастатическое поражение региональных лим-фатических узлов и наличие отдаленных метастазов

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Skull base surgery for pediatric parameningeal sarcomas

Abstract: Skull base surgery should be considered as a possible treatment in pediatric parameningeal sarcomas. Surgery is the only option in radiation-induced sarcoma. Larger studies are necessary to more clearly define surgical indications.

Cited by 4 publications

References 23 publications

Tumors Involving the Infratemporal Fossa: A Systematic Review of Clinical Characteristics and Treatment Outcomes

Tumors Involving the Infratemporal Fossa: A Systematic Review of Clinical Characteristics and Treatment Outcomes

¹²⁵I interstitial brachytherapy in management of pediatric skull base tumors

Clinical Significance of Transnasal Endoscopic Surgery in the Treatment of Children With Localized Parameningeal Sarcomas

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Skull base surgery for pediatric parameningeal sarcomas

Abstract: Skull base surgery should be considered as a possible treatment in pediatric parameningeal sarcomas. Surgery is the only option in radiation-induced sarcoma. Larger studies are necessary to more clearly define surgical indications.

Cited by 4 publications

References 23 publications

Tumors Involving the Infratemporal Fossa: A Systematic Review of Clinical Characteristics and Treatment Outcomes

Tumors Involving the Infratemporal Fossa: A Systematic Review of Clinical Characteristics and Treatment Outcomes

125I interstitial brachytherapy in management of pediatric skull base tumors

Clinical Significance of Transnasal Endoscopic Surgery in the Treatment of Children With Localized Parameningeal Sarcomas

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Product

Resources

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¹²⁵I interstitial brachytherapy in management of pediatric skull base tumors