SkinTE for the Treatment of a Complicated Wound after Synovial Sarcoma Resection: A Case Report

Abstract

Summary: Radiation therapy following oncologic resection can result in incisional breakdown, delay or cessation of wound healing, and exposure of structures. Impaired wound healing often mandates free tissue transfer for definitive closure and preservation of function. We present the case of a 16-year-old male patient who had a major incisional dehiscence following resection of a synovial sarcoma of the lower leg after postoperative irradiation. The progressive wound breakdown failed to respond to local wound care or negative pressure therapy and progressed to expose tendons of the distal leg. The patient was successfully treated with SkinTE, an autologous homologous skin graft and casting. Healing was slow but the wound filled with granulation tissue (which covered the tendon), epithelialized, and led to an excellent cosmetic and functional result. This highlights the potential of stem cell therapy and other forms of regenerative methods in healing of complicated wounds.