Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A

Weber, Teresa; Ceilley, Roger I.; Buerger, Anette; Kolbe, Ludger; Trookman, Nathan S.; Rizer, Ronald L.; Schoelermann, Andrea M.

doi:10.1111/j.1473-2165.2006.00261.x

Cited by 63 publications

(52 citation statements)

References 15 publications

(27 reference statements)

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“…Glycyrrhiza in fl ata's extract is licochalcone A, a bioactive ingredient that also has antiin fl ammatory effects thought to be due to inhibition of both cyclooxygenase and lipoxygenase [ 121 ] . Licochalcone A is reported to be useful in topical formulations for erythema reduction in rosacea-prone skin [ 122 ] .…”

Section: Lycoricementioning

confidence: 99%

Cosmeceuticals in Dermatology

Tedeschi

West

Guzzardi

et al. 2013

Update in Cosmetic Dermatology

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Section: Lycoricementioning

confidence: 99%

Cosmeceuticals in Dermatology

Tedeschi

West

Guzzardi

et al. 2013

Update in Cosmetic Dermatology

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“…Limited pilot clinical trials also have reported that some chalcones are well tolerated and non-toxic to humans and have reasonable pharmacokinetic properties [133]. Therefore, some lead chalcones are in the process of further characterization and optimization for investigative clinical trials for treatment of cancer, viral and cardiovascular disorders, and some have been in human use as cosmetic formulation ingredients and food additives [134–136]. These chalcones, either as nutraceuticals or as novel therapeutic agents, would provide a promising approach to cancer chemoprevention.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Molecular Targeted Approaches to Cancer Therapy and Prevention Using Chalcones

Jandial¹,

Blair²,

Zhang³

et al. 2014

CCDT

112

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There is an emerging paradigm shift in oncology that seeks to emphasize molecularly targeted approaches for cancer prevention and therapy. Chalcones (1,3-diphenyl-2-propen-1-ones), naturally-occurring compounds with widespread distribution in spices, tea, beer, fruits and vegetables, consist of open-chain flavonoids in which the two aromatic rings are joined by a three-carbon α, β-unsaturated carbonyl system. Due to their structural diversity, relative ease of chemical manipulation and reaction of α, β-unsaturated carbonyl moiety with cysteine residues in proteins, some lead chalcones from both natural products and synthesis have been identified in a variety of screening assays for modulating important pathways or molecular targets in cancers. These pathways and targets that are affected by chalcones include MDM2/p53, tubulin, proteasome, NF-kappa B, TRIAL/death receptors and mitochondria mediated apoptotic pathways, cell cycle, STAT3, AP-1, NRF2, AR, ER, PPAR-γ and β-catenin/Wnt. Compared to current cancer targeted therapeutic drugs, chalcones have the advantages of being inexpensive, easily available and less toxic; the ease of synthesis of chalcones from substituted benzaldehydes and acetophenones also makes them an attractive drug scaffold. Therefore, this review is focused on molecular targets of chalcones and their potential implications in cancer prevention and therapy.

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“…Additives of substances with skin-calming, anti-inflammatory, or vessel-stabilizing properties seem reasonable, but the benefit of such ingredients has been documented in clinical studies for only a few additives, like kinetin [40], retinaldehyde [41], and licochalcone A [42], as well as for some special mixtures of active ingredients [43, 44]. …”

Section: Formulations and Ingredients Of Dermocosmetics For Use In Romentioning

confidence: 99%

Dermocosmetics for Use in Rosacea: Guideline of the Society for Dermopharmacy

Kresken¹,

Kindl²,

Wigger‐Alberti³

et al. 2018

Skin Pharmacol Physiol

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Rosacea is a widespread inflammatory skin disease that is chronically recurrent and affects predominately the central parts of the face. Affected individuals typically react to numerous cosmetics with redness, burning, and/or worsening of the complexion. Consequently, there is a high demand for dermocosmetics that do not provoke such reactions and are suitable for use in rosacea. The present guideline of the Society for Dermopharmacy describes the requirements that dermocosmetics for use in rosacea should meet. They include, inter alia, methods to prove the efficacy of and tolerance to these cosmetics, as well as the product documentation that the manufacturer or the distributing company should make available to professionals, like dermatologists and pharmacists, counseling patients with rosacea.

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Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A

Abstract: The skin care regimen containing Lic A was found to be compatible with the sensitive facial skin of patients with rosacea and improved the appearance of persistent facial redness. The products were also observed to be compatible with daily metronidazole treatment.

Cited by 63 publications

References 15 publications

Cosmeceuticals in Dermatology

Cosmeceuticals in Dermatology

Molecular Targeted Approaches to Cancer Therapy and Prevention Using Chalcones

Dermocosmetics for Use in Rosacea: Guideline of the Society for Dermopharmacy

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