Skin Tissue Engineering

Keck, Maike; Lumenta, David B.; Kamolz, Lars‐Peter

doi:10.1007/978-3-7091-1586-2_2

Cited by 3 publications

(3 citation statements)

References 79 publications

(76 reference statements)

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“…The term “tissue engineering” was first coined almost 30 years ago, with skin being one of the first to be used clinically ( 34 ). Despite numerous successes in this exciting field, there have been very few reports of successful clinical translation.…”

Section: The Challengesmentioning

confidence: 99%

The Challenge for Reconstructive Surgeons in the Twenty-First Century: Manufacturing Tissue-Engineered Solutions

et al. 2015

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Section: The Challengesmentioning

confidence: 99%

The Challenge for Reconstructive Surgeons in the Twenty-First Century: Manufacturing Tissue-Engineered Solutions

et al. 2015

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“…Skin comprises approximately one-sixth of the body mass with a primary role of protecting the inner organs from the external environment . To remediate diseased or damaged tissue, skin tissue undergoes a remodeling process that begins with hematoma formation, followed by initiation of successive steps resulting in neo-skin regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Skin comprises approximately one-sixth of the body mass with a primary role of protecting the inner organs from the external environment. 1 To remediate diseased or damaged tissue, skin tissue undergoes a remodeling process that begins with hematoma formation, followed by initiation of successive steps resulting in neo-skin regeneration. This intricate process is hampered in certain circumstances, such as burns, trauma, or through disease (diabetes, neuropathies, lymphedema, dermatitis, and obesity), requiring surgery to facilitate tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

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Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling. These four steps significantly overlap with each other and are aided by various factors such as cells, cytokines (both anti- and pro-inflammatory), and growth factors that aid in the neo-tissue formation. In all these stages, advanced biomaterials provide several functional advantages, such as removing wound exudates, providing cover, transporting oxygen to the wound site, and preventing infection from microbes. In addition, advanced biomaterials serve as vehicles to carry proteins/drug molecules/growth factors and/or antimicrobial agents to the target wound site. In this review, we report recent advancements in biomaterials-based regenerative strategies that augment the skin tissue wound healing process. In conjunction with other medical sciences, designing nanoengineered biomaterials is gaining significant attention for providing numerous functionalities to trigger wound repair. In this regard, we highlight the advent of nanomaterial-based constructs for wound healing, especially those that are being evaluated in clinical settings. Herein, we also emphasize the competence and versatility of the three-dimensional (3D) bioprinting technique for advanced wound management. Finally, we discuss the challenges and clinical perspective of various biomaterial-based wound dressings, along with prospective future directions. With regenerative strategies that utilize a cocktail of cell sources, antimicrobial agents, drugs, and/or growth factors, it is expected that significant patient-specific strategies will be developed in the near future, resulting in complete wound healing with no scar tissue formation.

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Applications of Decellularized Materials for Tissue Repair

Liu

et al. 2021

Decellularized Materials

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Skin Tissue Engineering

Cited by 3 publications

References 79 publications

The Challenge for Reconstructive Surgeons in the Twenty-First Century: Manufacturing Tissue-Engineered Solutions

The Challenge for Reconstructive Surgeons in the Twenty-First Century: Manufacturing Tissue-Engineered Solutions

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Applications of Decellularized Materials for Tissue Repair

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