Proteins and lipids are very large natural molecules that possess many attributes for skin care and hair growth. Therefore, these molecules and the materials derived from them play a potential role in the aesthetic aspects of our society. In this context, the present chapter focuses on the role that protein- and lipid-based materials play in the field of cosmetics. The sources of lipids and proteins used in cosmetics have also been highlighted, keeping in view the role of nanoscale protein/lipid materials in the field of cosmetics. Moreover, recent advancements in the field have also been shown, which may be equally beneficial for readers who love to use natural materials as beauty ingredients and for people associated with the cosmetic industry.