2018
DOI: 10.1111/cod.13147
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Skin tests in patients with delayed and immediate hypersensitivity to heparins: A case series

Abstract: K E Y W O R D S : alternative, cross-reactions, cutaneous adverse drug reactions, delayed-type hypersensitivity, heparins, immediate-type hypersensitivity, intradermal test, patch test, prick test, skin tests Heparins constitute a group of anticoagulants that are widely used in clinical practice for the prophylaxis and treatment of thromboembolic events. Among the adverse events induced by heparins, delayed-type hypersensitivity (DTH) reactions are commonly reported, mostly as eczematous patches localized on t… Show more

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Cited by 4 publications
(7 citation statements)
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“…101 Heparins are known to provoke all types of hypersensitivity reactions. 101 Non-immediate ADR are common, especially eczematous patches localized on the injection sites, after a latency of 2-10 days to 3 weeks; [101][102] however, if heparin treatment is continued, there is a risk of a generalized eruption. 26 Only rarely generalized MPE and exceptionally TEN have been described.…”
Section: Heparinsmentioning
confidence: 99%
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“…101 Heparins are known to provoke all types of hypersensitivity reactions. 101 Non-immediate ADR are common, especially eczematous patches localized on the injection sites, after a latency of 2-10 days to 3 weeks; [101][102] however, if heparin treatment is continued, there is a risk of a generalized eruption. 26 Only rarely generalized MPE and exceptionally TEN have been described.…”
Section: Heparinsmentioning
confidence: 99%
“…104 Conversely, only a few cases of immediate ADR have been reported, as urticaria, angioedema, palmoplantar itch, dyspnoea, and anaphylaxis. [101][102] Risk factors for hypersensitivity include obesity, female sex, pregnancy, and prolonged treatment. [102][103][104][105] LMWH were the most frequent culprit heparins, probably because of their widespread use.…”
Section: Heparinsmentioning
confidence: 99%
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