Skin testing for immediate hypersensitivity to corticosteroids: a case series and literature review

Baker, Andrew B.; Empson, Marianne; Fitzharris, Penny

doi:10.1111/cea.12441

Cited by 31 publications

(23 citation statements)

References 22 publications

(43 reference statements)

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“…Baker et al [18] reported on a case series of 23 patients with suspected corticosteroid hypersensitivity. Almost all of the cases with a positive skin test had a history of anaphylaxis; intra-articular triamcinolone acetonide was the causative agent in 5 out of 8 patients.…”

Section: Discussionmentioning

confidence: 99%

Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection

Laisuan

Wongsa

Dchapaphapeaktak

et al. 2017

Asia Pacific Allergy

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Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any reaction for the previous 10 years. The immediate reaction occurred 15 minutes after injection, with numbness on her face and 5 minutes later with urticaria on her chest wall and upper extremities, together with hypotension (blood pressure of 90/60 mmHg). Allergology workup revealed positive skin prick test for triamcinolone acetonide (Kenacort). Skin tests for other corticosteroids (hydrocortisone, methylprednisolone, and dexamethasone), excipients (carboxymethylcellulose, benzyl alcohol, and polysorbate 80) and lidocaine were negative, including subcutaneous challenge for lidocaine and oral challenge for carboxymethylcellulose. IgE-mediated hypersensitivity reaction must be considered in cases of multiple applications of triamcinolone acetonide injection.

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Section: Discussionmentioning

confidence: 99%

Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection

Laisuan

Wongsa

Dchapaphapeaktak

et al. 2017

Asia Pacific Allergy

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“…In most subjects with IHRs, it is possible to identify the culprit and safe alternative GCs by performing immediate‐reading STs 178‐185 . In the aforementioned review, 74.1% of 112 STs carried out with GCs suspected of being responsible for reactions were positive 181 .…”

Section: Anti‐cytokine/anti‐inflammatory Drugs Used For Mas/cytokine mentioning

confidence: 99%

“…In the allergy workup, negative results in STs should be confirmed with DPTs 180‐185 . DPTs are also recommended to ensure tolerance of alternative preparations 184 .…”

Section: Anti‐cytokine/anti‐inflammatory Drugs Used For Mas/cytokine mentioning

confidence: 99%

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper

Gelincik

Brockow

Çelik

et al. 2020

Allergy

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Coronavirus disease 2019 (COVID‐19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Given the huge influence caused by the overwhelming COVID‐19 pandemic affecting over three million people worldwide, a wide spectrum of drugs is considered for the treatment in the concept of repurposing and off‐label use. There is no knowledge about the diagnosis and clinical management of the drug hypersensitivity reactions that can potentially occur during the disease. This review brings together all the published information about the diagnosis and management of drug hypersensitivity reactions due to current and candidate off‐label drugs and highlights relevant recommendations. Furthermore, it gathers all the dermatologic manifestations reported during the disease for guiding the clinicians to establish a better differential diagnosis of drug hypersensitivity reactions in the course of the disease.

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“…A hipersensibilidade aos CT, com apresentação imediata ou tardia, tem sido descrita na literatura nos últimos 30 anos 9 . O diagnóstico de uma reação de hipersensibilidade a CT continua a ser um desafio 9 .…”

Section: Artigo De Revisãounclassified

Hipersensibilidade a corticosteroides – Uma revisão

Coutinho

Pita

Moura

et al. 2020

rpia

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Os corticosteroides são fármacos anti-inflamatórios amplamente utilizados na prática clínica e as reações de hipersensibilidade, com apresentação imediata ou tardia têm sido cada vez mais descritas na literatura. As reações de hipersensibilidade podem ocorrer devido aos corticosteroides ou aos excipientes utilizados nas suas preparações. Os testes cutâneos podem auxiliar na confirmação diagnóstica e na identificação de uma alternativa terapêutica. O presente trabalho tem como objetivo a revisão do conhecimento atual sobre a apresentação clínica, a avaliação e abordagem diagnóstica das reações de hipersensibilidade imediata e tardia a corticosteroides.

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Skin testing for immediate hypersensitivity to corticosteroids: a case series and literature review

Abstract: As the largest case series described, this article provides new evidence for the interpretation of skin tests when investigating possible immediate hypersensitivity to corticosteroids.

Cited by 31 publications

References 22 publications

Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection

Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper

Hipersensibilidade a corticosteroides – Uma revisão

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