Skin test anergy in advanced heart failure secondary to either ischemic or idiopathic dilated cardiomyopathy

Vredevoe, Donna L.; Woo, Mary A.; Doering, Lynn V.; Brecht, Mary Lynn; Hamilton, Michèle A.; Fonarow, Gregg C.

doi:10.1016/s0002-9149(98)00334-8

Cited by 48 publications

(36 citation statements)

References 12 publications

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“…Hence, higher serum cholesterol is suggested to be beneficial in these patients. 35,36 Increased resting energy expenditure in CHF has been reported, 6 and this may play a role in the unexplained weight loss that is part of wasting in CHF. Adiponectin has recently been suggested to increase energy expenditure and induce weight loss through a direct effect on the brain.…”

Section: Discussionmentioning

confidence: 98%

Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure

et al. 2005

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Background-Recent studies have suggested that higher body mass index (BMI) is associated with improved prognosis in chronic heart failure (CHF). The adipocytokine adiponectin is inversely associated with BMI, and in healthy subjects, low adiponectin is a predictor of mortality. In a prospective study, we therefore evaluated the association between plasma adiponectin levels and mortality among patients with CHF. Methods and Results-In 195 CHF patients (age 69.3Ϯ10.2 years, BMI 27.3Ϯ5.2 kg/m 2 , left ventricular ejection fraction 30Ϯ8.9%, meanϮSD), plasma adiponectin and N-terminal pro brain natriuretic peptide (NT-proBNP) were measured at baseline. Adiponectin was positively associated with NT-proBNP (␤ϭ0.47, PϽ0.001), and both biomarkers were negatively associated with BMI (␤ϭϪ0.43, PϽ0.001 for adiponectin and ␤ϭϪ0.38, PϽ0.001 for NT-proBNP, respectively) During a median follow-up of 2.6 years, 46 (23.5%) of the patients died. After adjustment for clinical variables associated with CHF severity (age, systolic blood pressure, left ventricular ejection fraction Ͻ25%, duration of CHF, and creatinine clearance) and for NT-proBNP, the hazard ratio of mortality for values in the 2 upper tertiles relative to the lowest tertile of adiponectin was 3.23 (Pϭ0.032). BMI predicted mortality independently of clinical parameters of CHF severity (hazard ratioϭ0.63, Pϭ0.012), but this association became insignificant after additional adjustment for Pϭ0.13). Conclusions-A high adiponectin level was a predictor of mortality, independent of risk markers of CHF severity, presumably because of its role as a marker for wasting. BMI was also associated with mortality, but a part of this relation may be mediated by adiponectin and NT-proBNP levels.

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Section: Discussionmentioning

confidence: 98%

Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure

et al. 2005

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“…It would be reasonable to expect that high cholesterol would be a risk factor and have deleterious effects on mortality in patients with established HF. However, preliminary reports have suggested that there is an increased mortality in HF patients with low cholesterol (Richartz et al 1998;Vredevoe et al 1998;Rauchhaus et al 2000).…”

confidence: 99%

“…Tumor necrosis factor-α (TNF-α ) and other proinflammatory cytokine parameters can be elevated in patients with advanced coronary HF (Levine et al 1990;Anker et al 1997). It has been reported that higher cholesterol levels were associated with lower levels of TNF-α (Vredevoe et al 1998).…”

confidence: 99%

Decreased Serum Lipoprotein Levels as a Guide for Clinical Severity in Patients with Idiopathic Dilated Cardiomyopathy

Sezgin

Güllü

et al. 2005

Tohoku J. Exp. Med.

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Hyperlipidemia is a cardiovascular risk factor. In patients with idiopathic dilated cardiomyopathy (IDC), prognostic roles of endogenous lipoproteins are not fully clarified. It has been known that there is a direct relationship between the levels of cytokines (tumor necrosis factor-α [TNF-α ] and interleukin-6 [IL-6]) and deteriorating functional classes of heart failure and mortality. The present study compared the levels of circulating TNF-α , IL-6, lipoproteins, and apolipoproteins in patients with stable IDC (n = 28) with those of patients with unstable IDC (n = 26) and controls (n = 24). Mean serum total cholesterol (TC) was significantly lower in stable IDC patients than controls (p < 0.05). In unstable IDC patients, mean serum TC was also lower than controls but not statistically significant. The IDC patients had significantly higher concentrations of IL-6 and TNF-α than the controls (p < 0.01). Serum IL-6 and Apo AI levels were significantly different between stable and unstable IDC patients (p = 0.021 and p = 0.012, respectively). Increased levels of IL-6 were associated with decreased levels of TC (r = −0.266, p = 0.019), LDL-C (r = −0.376, p = 0.001) and apolipoprotein AI (apo AI) (r = −0.495, p < 0.001) in all IDC patients. TNF-α was also inversely related to apo AI (r = −0.455, p < 0.001) and LDL-C (r = −0.364, p = 0.001) in all patients. Thus, elevated serum levels of cytokines in patients with IDC are associated with decreased lipoprotein concentrations, which may indicate impaired prognosis. heart failure; lipoprotein; apolipoprotein; cytokine

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“…As we were expecting, heart failure patients presented low lipid fraction values. It is postulated that low lipid fraction levels suggest a bad prognosis for end-stage heart failure patients and at the same time they represent strong risk factors for mortality in these individuals [23][24][25][26]. Congestive hepatopathy occurs in an advanced chronic heart failure and leads to low plasma lipid fraction levels.…”

Section: Discussionmentioning

confidence: 99%

Renin Genetic Polymorphism in Heart Failure Patients

Pop

Sitar-Tăut

Procopciuc

et al. 2015

Romanian Journal of Internal Medicine

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Background. Genetic polymorphism of renin-angiotensin-aldosterone system affects the pathogenesis of hypertension (HTN), ischemic heart disease (IHD) and heart failure (HF). The purpose of our study is to analyze A/G renin genetic polymorphism in heart failure patients.Methods. We investigated renin polymorphism in 83 subjects hospitalized in the Cardiology Department of the Rehabilitation Hospital Cluj-Napoca, using the PCR amplification method. 43 patients were diagnosed with heart failure [NYHA III-IV class], and 40 subjects without cardiovascular disease (control group). The NT-proBNP and the presence of cardiovascular risk factors were assessed.Results. Heart failure etiology was IHD in 60.46 % of patients. The average value of NT-pro BNP was 2991.24 ± 2034.6 pg/ml. As it was expected, HF patients presented low lipid levels: total cholesterol = 162.36 ± 38.28mg/dl, LDL-Cholesterol = 104.88 ± 27.60mg/dl, triglycerides= 109.12 ± 55.84mg/dl, HDL-Co= 35.68 ± 9.55mg/dl. A/G renin genetic polymorphism [with pathogenic potential] in heart failure patients was of 60.46% (homozygote 4.65% and heterozygote 55.81%). Conversely, pathogenic mutations were found only in 38.46% of hypertensive patients, but also in 55.88% and 22.22% patients with obesity/overweight and diabetes. The heterozygote form was found in only 37.5% of control subjects.Conclusion. This study showed no involvement of A/G renin polymorphisms in the pathogenesis of HF.

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Skin test anergy in advanced heart failure secondary to either ischemic or idiopathic dilated cardiomyopathy

Cited by 48 publications

References 12 publications

Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure

Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure

Decreased Serum Lipoprotein Levels as a Guide for Clinical Severity in Patients with Idiopathic Dilated Cardiomyopathy

Renin Genetic Polymorphism in Heart Failure Patients

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