Skin targeting by chitosan/hyaluronate hybrid nanoparticles for the management of irritant contact dermatitis: In vivo therapeutic efficiency in mouse-ear dermatitis model

Abuelella, Khaled E.; Abd-Allah, Hend; Soliman, Sara M.; Abdel-Mottaleb, Mona M.A.

doi:10.1016/j.ijbiomac.2023.123458

Cited by 11 publications

(4 citation statements)

References 64 publications

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“…Different types of organic nanoparticles of pharmaceutical interest have been obtained on the scale of milligrams, by the planetary ball milling process. Mostly, these nanomaterials are composed of drugs loaded on liposomes or polymers, such as chitosan, or nanosponge [ 38 , 39 , 40 , 41 , 42 ]. In the present manuscript, different outcomes have been reported.…”

Section: Discussionmentioning

confidence: 99%

The Formulation of the N-Acetylglucosamine as Nanoparticles Increases Its Anti-Inflammatory Activities: An In Vitro Study

Mariano

Bigioni

Ammendola³

et al. 2023

Bioengineering

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Nanomedicine can represent a new strategy to treat several types of diseases such as those with inflammatory aetiology. Through this strategy, it is possible to obtain nanoparticles with controlled shape, size, and eventually surface charge. Moreover, the use of molecules in nanoform may allow more effective delivery into the diseased cells and tissues, reducing toxicity and side effects of the used compounds. The aim of the present manuscript was the evaluation of the effects of N-acetylglucosamine in nanoform (GlcNAc NP) in an in vitro model of osteoarthritis (OA). Human primary chondrocytes were treated with Tumor Necrosis Factor (TNF)-α to simulate a low-grade inflammation and then treated with both GlcNAc and GlcNAc NP, in order to find the lowest concentrations able to counteract the inflammatory state of the cells and ensure a chondroprotective action. The findings showed that GlcNAc NP was able to decrease the pro-inflammatory mediators, IL-6 and IL-8, which are among the main effectors of inflammation; moreover, the nanoparticles downregulated the production of metalloprotease enzymes. GlcNAc NP was effective at a very low concentration compared to GlcNAc in its native form. Furthermore, GlcNAc NP stimulated an increase in collagen type II synthesis. In conclusion, the GlcNAc in nanoform showed better performance than GlcNAc, at concentrations lower than those reached in the joints after oral administration to patients of 1.5 g/die of glucosamine.

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Section: Discussionmentioning

confidence: 99%

The Formulation of the N-Acetylglucosamine as Nanoparticles Increases Its Anti-Inflammatory Activities: An In Vitro Study

Mariano

Bigioni

Ammendola³

et al. 2023

Bioengineering

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“…Nanotechnology offers promising approaches to overcome the limitations of conventional drug delivery systems and improve the efficacy of treatment of psoriasis. Various nano-based drug delivery systems enable the delivery of the required therapeutic dose allowing drug accumulation and retention within skin layers [ 40 ]. Thus, they serve as controlled drug delivery systems, in turn reducing dosing frequency, and hence, enhancing patient compliance, as well as reducing systemic adverse effects, systemic toxicity and skin irritation.…”

Section: Nano-based Topical Drug Delivery Systemsmentioning

confidence: 99%

Can Essential Oils/Botanical Agents Smart-Nanoformulations Be the Winning Cards against Psoriasis?

et al. 2023

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Although psoriasis remains one of the most devastating inflammatory disorders due to its huge negative impact on patients’ quality of life, new “green” treatment approaches still need to be fully explored. The purpose of this review article is to focus on the utilization of different essential oils and active constituents of herbal botanical origin for the treatment of psoriasis that proved efficacious via both in vitro and in vivo models. The applications of nanotechnology-based formulations which displayed great potential in augmenting the permeation and delivery of these agents is also addressed. Numerous studies have been found which assessed the potential activity of natural botanical agents to overcome psoriasis. Nano-architecture delivery is applied in order to maximize the benefits of their activity, improve properties, and increase patient compliance. This field of natural innovative formulations can be a promising tool to optimize remediation of psoriasis while minimizing adverse effects.

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“…Two main types of CD have been described according to the pathophysiological mechanism involved: irritant CD (ICD) and allergic CD (ACD). [10][11][12][13][14][15][16] ICD is the most common occupational skin disease, accounting for 80% of all CD cases. It can occur after a single exposure to an irritant or toxic substance (e.g., abrasives, cleaning, oxidizing, and reducing agents) and is characterized by skin damage caused by a direct, local cytotoxic effect on skin cells.…”

Section: Introductionmentioning

confidence: 99%

“…Skin problems related to chemical contact are constantly growing environmental and occupational health problems. Two main types of CD have been described according to the pathophysiological mechanism involved: irritant CD (ICD) and allergic CD (ACD) 10–16 . ICD is the most common occupational skin disease, accounting for 80% of all CD cases.…”

Section: Introductionmentioning

confidence: 99%

Systemic allergic contact dermatitis to palladium, platinum, and titanium: mechanisms, clinical manifestations, prevalence, and therapeutic approaches

Sadrolvaezin,

Pezhman,

Zare

et al. 2023

MedComm

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Contact dermatitis (CD) is an inflammatory skin disease of eczema that is elicited by chemicals or metal ions that have toxic effects without eliciting a T‐cell response (contact elicitation) or by small reactive chemicals that modify proteins and induce innate and adaptive immune responses (contact allergens). The clinical condition is characterized by localized skin rash, pruritus, redness, swelling, and lesions, which are mainly detected by patch tests and lymphocyte stimulation. Heavy metals such as palladium (Pd), platinum (Pt), and titanium (Ti) are ubiquitous in our environment. These heavy metals have shown CD effects as allergic agents. Immunological responses result from the interaction of cytokines and T cells. Occupational metal CD accounts for most cases of work‐related cutaneous disorders. In this systematic review, the allergic effects of heavy metals, including Pd, Pt, and Ti, and the mechanisms, clinical manifestations, prevalence, and therapeutic approaches are discussed in detail. Furthermore, the therapeutic approaches introduced to treat CD, including corticosteroids, topical calcineurin inhibitors, systemic immunosuppressive agents, phototherapy, and antihistamines, can be effective in the treatment of these diseases in the future. Ultimately, the insights identified could lead to improved therapeutic and diagnostic pathways.

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Skin targeting by chitosan/hyaluronate hybrid nanoparticles for the management of irritant contact dermatitis: In vivo therapeutic efficiency in mouse-ear dermatitis model

Cited by 11 publications

References 64 publications

The Formulation of the N-Acetylglucosamine as Nanoparticles Increases Its Anti-Inflammatory Activities: An In Vitro Study

The Formulation of the N-Acetylglucosamine as Nanoparticles Increases Its Anti-Inflammatory Activities: An In Vitro Study

Can Essential Oils/Botanical Agents Smart-Nanoformulations Be the Winning Cards against Psoriasis?

Systemic allergic contact dermatitis to palladium, platinum, and titanium: mechanisms, clinical manifestations, prevalence, and therapeutic approaches

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