Skin substitutes for burn wound healing: current and future approaches

Supp, Dorothy M.

doi:10.1586/edm.10.73

Cited by 12 publications

(10 citation statements)

References 104 publications

(131 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Full- or split-thickness skin grafting is the current gold standard for wound closure following severe burn wound injury. A few synthetic substitutes have made their ways to the market, but most provide only a temporary barrier until autografts are available for permanent closure ( Supp, 2011 ). To the best of our knowledge, there is no synthetic product currently indicated for treating third-degree burns.…”

Section: Discussionmentioning

confidence: 99%

Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model

Shen

Song

Papa

et al. 2015

Journal of Investigative Dermatology

View full text Add to dashboard Cite

Currently available skin grafts and skin substitute for healing following third-degree burn injuries is fraught with complications, often resulting in long-term physical and psychological sequelae. Synthetic treatment that can promote wound healing in a regenerative fashion would provide an off-the-shelf, non-immunogenic strategy to improve clinical care of severe burn wounds. Here, we demonstrate vulnerary efficacy and accelerated healing mechanism of dextran-based hydrogel in third-degree porcine burn model. The model was optimized to allow examination of the hydrogel treatment for clinical translation and its regenerative response mechanisms. Hydrogel treatment accelerated third-degree burn wound healing by rapid wound closure, improved reepithelialization, enhanced extracellular matrix remodeling, and greater nerve reinnervation, compared to the dressing treated group. These effects appear to be mediated through the ability of the hydrogel to facilitate a rapid but brief initial inflammatory response that coherently stimulates neovascularization within the granulation tissue during the first week of treatment, followed by an efficient vascular regression to promote a regenerative healing process. Our results suggest that the dextran-based hydrogels may substantially improve healing quality and reduce skin grafting incidents and thus pave the way for clinical studies to improve the care of severe burn injury patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model

Shen

Song

Papa

et al. 2015

Journal of Investigative Dermatology

View full text Add to dashboard Cite

show abstract

“…Apligraf is an only commercially available composite bi-layer product which is approved by FDA for the treatment of chronic venous ulcers (Veves et al 2001 ; Zaulyanov and Kirsner 2007 ). Patients, treatment with apligraf, experienced faster healing and decreased the complication rate, by this it meant less need for medical follow up (Límová 2010 ; Supp 2011 ). Apligraf accelerates healing in diabetic neuropathic ulcers as compared with standard therapy of moist gauze and offloading (Supp 2011 ).…”

Section: Skin Substitutes Containing Allogenic Live Fibroblastsmentioning

confidence: 99%

Synthetic polymeric biomaterials for wound healing: a review

et al. 2018

View full text Add to dashboard Cite

Wounds are of a variety of types and each category has its own distinctive healing requirements. This realization has spurred the development of a myriad of wound dressings, each with specific characteristics. It is unrealistic to expect a singular dressing to embrace all characteristics that would fulfill generic needs for wound healing. However, each dressing may approach the ideal requirements by deviating from the ‘one size fits all approach’, if it conforms strictly to the specifications of the wound and the patient. Indeed, a functional wound dressing should achieve healing of the wound with minimal time and cost expenditures. This article offers an insight into several different types of polymeric materials clinically used in wound dressings and the events taking place at cellular level, which aid the process of healing, while the biomaterial dressing interacts with the body tissue. Hence, the significance of using synthetic polymer films, foam dressings, hydrocolloids, alginate dressings, and hydrogels has been reviewed, and the properties of these materials that conform to wound-healing requirements have been explored. A special section on bioactive dressings and bioengineered skin substitutes that play an active part in healing process has been re-examined in this work.

show abstract

“…Nonetheless, while advances in clinical management and therapeutic modalities have been achieved, serious limitations in the improvement of wound healing remain, largely due to the complexity of the underlying biology [1-3]. It is widely recognized that a significant improvement in outcomes will come as a result of biologically active therapies for wound healing [4]. A variety of efforts are underway to develop bioengineered skin substitutes to function as “artificial skin.” Unfortunately, because they involve the use of grafted cells, most of these approaches are expensive, labor intensive, present numerous medical and regulatory issues, and results of clinical studies are inconsistent with respect to the efficacy of specific products [5].…”

Section: Introductionmentioning

confidence: 99%

An electrospun scaffold integrating nucleic acid delivery for treatment of full-thickness wounds

et al. 2013

View full text Add to dashboard Cite

We developed a multi-functional construct capable of controlled delivery of bioactive substances that can improve wound repair by supporting the intrinsic ability of the skin to heal. We synthesized electrospun scaffolds—composed of a blend of the degradable polymers poly(L-lactide) (PLA) or polycaprolactone (PCL)—that produce highly efficient non-viral in vivo gene delivery to cells in the wound bed, provide a protective barrier during early wound healing, and support cell migration and growth. This multi-functional material was tested for its influence on wound healing: scaffolds were loaded with plasmids encoding keratinocyte growth factor (KGF) and applied to full thickness wounds in mice. Compared to scaffolds with control plasmids, animals receiving the KGF plasmid-loaded scaffold produced significant enhancements in wound healing, which was quantified by improvements in the rate of wound re-epithelialization, keratinocyte proliferation, and granulation response. Further, we quantified the expression level of endogenous and plasmid-derived KGF in wound samples: qRT-PCR on wound sections revealed a correlation between the levels of plasmid-derived protein expression and histological analysis of wound healing, revealing an inverse relationship between the expression level of exogenous KGF and the size of the unhealed epithelial layer in wounds. Our findings suggest that engineered nanofiber PLA/PCL scaffolds are capable of highly efficient controlled DNA delivery and are promising materials for treatment of cutaneous wounds.

show abstract

Skin substitutes for burn wound healing: current and future approaches

Cited by 12 publications

References 104 publications

Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model

Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model

Synthetic polymeric biomaterials for wound healing: a review

An electrospun scaffold integrating nucleic acid delivery for treatment of full-thickness wounds

Contact Info

Product

Resources

About